Detalhe da pesquisa
1.
Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic Leukodystrophy Arsa Knock-Out Mice.
J Neurosci
; 43(19): 3567-3581, 2023 05 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36977578
2.
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Proc Natl Acad Sci U S A
; 116(5): 1723-1732, 2019 01 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30559189
3.
Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.
J Biol Chem
; 290(25): 15496-15511, 2015 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25947382
4.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Xenobiotica
; 43(11): 963-72, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23631744
5.
Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression.
J Lipid Res
; 53(8): 1459-71, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22628619
6.
The PPARα agonists fenofibrate and CP-778875 cause increased ß-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.
Toxicol Pathol
; 40(3): 435-47, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22301950
7.
Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS.
Mol Ther Methods Clin Dev
; 26: 224-238, 2022 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35859693
8.
Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
J Lipid Res
; 52(11): 1974-83, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21771977
9.
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
Cell Metab
; 1(2): 121-31, 2005 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16054053
10.
Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection.
J Lipid Res
; 51(5): 967-74, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19965592
11.
A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys.
J Pharmacol Exp Ther
; 333(3): 844-53, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20190014
12.
Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH.
Mol Ther Methods Clin Dev
; 17: 568-580, 2020 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32258219
13.
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1.
J Lipid Res
; 50(7): 1330-9, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19237735
14.
Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo.
Mol Pharmacol
; 75(2): 296-306, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18971326
15.
Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus.
Am J Cardiol
; 102(4): 434-9, 2008 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18678301
16.
Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARalpha.
Gene
; 380(2): 84-94, 2006 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16828988
17.
Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages.
Arterioscler Thromb Vasc Biol
; 25(6): 1198-205, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15831807
18.
ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation.
Arterioscler Thromb Vasc Biol
; 23(6): 972-80, 2003 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12615679
19.
Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages.
Arterioscler Thromb Vasc Biol
; 22(4): 630-7, 2002 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-11950702
20.
Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.
J Invest Dermatol
; 135(12): 3060-3067, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26203639