RESUMO
Rat bite fever is a rare infection usually caused by Streptobacillus moniliformis. A case of septic arthritis and possible osteomyelitis as sequelae of rat bite fever in a pediatric patient is described.
Assuntos
Artrite Infecciosa/complicações , Artrite Infecciosa/patologia , Osteomielite/etiologia , Osteomielite/patologia , Febre por Mordedura de Rato/complicações , Febre por Mordedura de Rato/patologia , Streptobacillus/isolamento & purificação , Quadril/diagnóstico por imagem , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , RadiografiaRESUMO
We report an 8 year-old girl with well-controlled perinatally acquired HIV infection who developed autoimmune type 1 diabetes mellitus (DM1A) confirmed by the presence of diabetes-related auto-antibodies. Although non-autoimmune insulin dependent diabetes mellitus (DM1B) and more frequently type 2 DM has been reported in patients affected with HIV, this is the first report of DM1A diagnosed in an HIV positive patient.
Assuntos
Autoanticorpos/imunologia , Diabetes Mellitus Tipo 1/imunologia , Infecções por HIV/imunologia , Antirretrovirais/uso terapêutico , Diabetes Mellitus Tipo 1/etiologia , Feminino , Infecções por HIV/complicações , Infecções por HIV/tratamento farmacológico , HumanosRESUMO
In March 1995, the US Food and Drug Administration approved a live attenuated varicella vaccine for use in healthy children 12 months to 12 years old. We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine.
Assuntos
Vacina contra Varicela/efeitos adversos , Varicela/etiologia , Varicela/imunologia , Linfócitos T/imunologia , Varicela/diagnóstico , Feminino , Humanos , Síndromes de Imunodeficiência/complicações , Síndromes de Imunodeficiência/imunologia , LactenteRESUMO
BACKGROUND: CD8 cell responses to human immunodeficiency virus (HIV) have been correlated with virus control in adults, and this study outcome has been controversial. Attempts to establish the same correlation in small numbers of children have also been made, with similar controversy resulting. METHODS: A total of 110 perinatally infected children were studied. Nine of the children (mean age, 1.9 years vs. 11.8 years for the remaining 101 children) received treatment with antiretrovirals within the first 3 months of life. CD4 cell and HIV RNA levels were measured. Production of interferon- gamma after exposure to recombinant vaccinia vectors was measured by enzyme-linked immunospot (ELISPOT) assay. RESULTS: Responses to Pol and Gag antigens exceeded those to Nef and Env antigens, with responses significantly approximated by a quadratic function for which peak responses occurred at plasma HIV RNA levels of 103-104 HIV RNA copies/mL. Children who are treated early in life with highly active antiretroviral therapy have fewer total responses of ELISPOT-forming cells to HIV antigens than do children who are treated later in life.
Assuntos
Linfócitos T CD8-Positivos/imunologia , Infecções por HIV/imunologia , Infecções por HIV/virologia , HIV-1/isolamento & purificação , Adolescente , Adulto , Antirretrovirais/uso terapêutico , Criança , Pré-Escolar , Estudos Transversais , Antígenos HIV/imunologia , Infecções por HIV/tratamento farmacológico , HIV-1/genética , HIV-1/imunologia , Humanos , Lactente , Recém-Nascido , Interferon gama/análise , Masculino , RNA Viral/sangue , Especificidade da Espécie , Carga ViralRESUMO
A 7-month-old infant with cutaneous anthrax developed severe systemic illness despite early treatment with antibiotics. The infant displayed severe microangiopathic hemolytic anemia with renal involvement, coagulopathy, and hyponatremia. These findings are unusual with cutaneous anthrax, but have been described in illness resulting from spider toxin and may delay correct diagnosis. The systemic manifestations of the disease persisted for nearly a month despite corticosteroid therapy, but resolved.