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1.
Zoonoses Public Health ; 70(4): 315-326, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36692076

RESUMO

Between June and August 2014, 45 cases of leptospirosis were notified among workers on two strawberry farms in North-West Germany. We describe the characteristics of the outbreak and the actions taken to prevent further cases. The activities of the local, federal and national public health and veterinary authorities included collection of case data, laboratory testing of human specimens and of small mammals trapped on the fields, investigation of weather data, as well as information provided to farmers, field workers, physicians and to the authorities in Poland and Romania. Of the 45 identified cases (median age 22, 60% male), 47% were hospitalized. Characteristic symptoms were fever ≥38.5°C, generalized muscle pain and an increase in renal or liver enzymes. Thirteen cases were laboratory confirmed by serological and/or molecular methods. ELISA tests for Leptospira IgG and IgM-antibodies were positive in those samples taken >5 days after hospitalization. The probable causative agent was identified as Leptospira kirschneri serovar Grippotyphosa. Leptospira-specific DNA was found in kidneys of 67% of 64 trapped small mammals and was further identified as Leptospira kirschneri multi locus sequence type 110. During the estimated time period of human infections, the affected region faced warm weather with heavy rainfalls. The results of this investigation are in accordance with the theory of a chain of infection from mice to field workers during warm and humid weather. In 2015, a campaign was initiated to inform physicians, farmers and workers to enhance prevention measures, such as the use of personal protective equipment and early consultation of physicians in case of illness. Since then, no further outbreak occurred.


Assuntos
Leptospira , Leptospirose , Masculino , Animais , Humanos , Camundongos , Feminino , Leptospirose/epidemiologia , Leptospirose/veterinária , Leptospira/genética , Mamíferos , Alemanha/epidemiologia , Surtos de Doenças
2.
Pest Manag Sci ; 69(3): 403-8, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22888034

RESUMO

BACKGROUND: Genetically based resistance to anticoagulants has led to increasing difficulties in the control of rodents over recent decades. The possible impact of rodenticide-resistant rats on the infection risk of humans and livestock by zoonotic pathogens is generally unknown. Hence, in a monitoring programme in the German federal states of Lower Saxony and Hamburg, more than 500 Norway rats were analysed for both Tyr139Cys polymorphisms within the VKORC1 gene and zoonotic agents. RESULTS: Evidence of resistance was almost completely restricted to the known resistance area in southern Lower Saxony. Homozygous mutations were only found in urban areas sampled owing to the occurrence of rat control problems and were missing in bycatches of rats by muskrat trappers in rural areas. In more than 25% of the rats, zoonotic bacteria (Leptospira, Salmonella, Yersinia and Coxiella) were detected. There was no obvious correlation between the occurrence of rats carrying zoonotic pathogens and anticoagulant resistance. CONCLUSION: Zoonotic agents and genetically based resistance conferred by the Tyr139Cys polymorphism are both unevenly distributed in Lower Saxony. The study provides the basis for further studies focusing on districts with high levels of pathogens and resistance to assess the potential health risk of their combined occurrence.


Assuntos
Resistência a Medicamentos , Ratos/fisiologia , Rodenticidas/farmacologia , Zoonoses/microbiologia , Animais , Bactérias/isolamento & purificação , Alemanha , Oxigenases de Função Mista/genética , Oxigenases de Função Mista/metabolismo , Mutação de Sentido Incorreto , Polimorfismo de Nucleotídeo Único , Ratos/genética , Ratos/microbiologia , Controle de Roedores , Vitamina K Epóxido Redutases , Zoonoses/transmissão
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