Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and stage 5 chronic kidney disease under dialysis: A systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: In patients with atrial fibrillation (AF) and normal or slightly impaired renal function, the use of direct oral anticoagulants (DOACs) is preferable to vitamin K antagonists (VKAs). However, in patients undergoing hemodialysis, the efficacy, and safety of DOACs compared with VKAs are still unknown. PURPOSE: To review current evidence about the safety and efficacy of DOACs compared to VKAs, in patients with AF and chronic kidney disease under hemodialysis. METHODS: We systematically searched PubMed, Scopus, and Cochrane databases for RCTs comparing DOACs with VKAs for anticoagulation in patients with AF on dialysis therapy. Outcomes of interest were: (1) stroke; (2) major bleeding; (3) cardiovascular mortality; and (4) all-cause mortality. Statistical analysis was performed using RevMan 5.1.7 and heterogeneity was assessed by I2 statistics. RESULTS: Three randomized controlled trials were included, comprising a total of 383 patients. Of these, 218 received DOACs (130 received apixaban; 88 received rivaroxaban), and 165 were treated with VKAs (116 received warfarin; 49 received phenprocoumon). The incidence of stroke was significantly lower in patients treated with DOACs (4.7%) compared with those using VKAs (9.5%) (RR 0.42; 95% CI 0.18-0.97; p = 0.04; I2 = 0%). However, the difference was not statistically significant in the case of ischemic stroke specifically (RR 0.42; 95% CI 0.17-1.04; p = 0.06; I2 = 0%). As for the major bleeding outcome, the DOAC group (11%) had fewer events than the VKA group (13.9%) but without statistical significance (RR 0.75; 95% CI 0.45-1.28; p = 0.29; I2 = 0%). There was no significant difference between groups regarding cardiovascular mortality (RR 1.23; 95% CI 0.66-2.29; p = 0.52; I2 = 13%) and all-cause mortality (RR 0.98; 95% CI 0.77-1.24; p = 0.84; I2 = 16%). CONCLUSION: This meta-analysis suggests that in patients with AF on dialysis, the use of DOACs was associated with a significant reduction in stroke, and a numerical trend of less incidence of major bleeding compared with VKAs, but in this case with no statistical significance. Results may be limited by a small sample size or insufficient statistical power.

Long-term profile attractiveness of patients with Class I and II malocclusion treated with and without extractions: A 35-year follow-up.

INTRODUCTION: The objective of this study was to compare the profile attractiveness in subjects treated with and without extractions after the long-term 35-year follow-up, according to laypeople, dentists, and orthodontists. METHODS: A total of 40 patients with Class I and II malocclusion were divided into 2 groups, according to the treatment protocol: extraction (E) group, extractions of 4 premolars (n = 24), with mean pretreatment (T1), posttreatment (T2), and long-term posttreatment (T3) ages of 13.13, 15.50 and 49.56 years, respectively. The mean treatment time (T2 - T1) was 2.37 years, and the long-term follow-up (T3 - T2) was 34.19. Nonextraction (NE) group (n = 16), with mean ages at T1, T2, and T3 of 13.21, 15.07, and 50.32 years, respectively. The mean (T2 - T1) was 1.86 years, and the (T3 - T2) was 35.25 years. Lateral cephalograms were used to perform profile facial silhouettes, and an online evaluation was performed by 72 laypeople, 63 dentists, and 65 orthodontists, rating the attractiveness from 1 (least attractive) to 10 (most attractive). The intragroup comparison was performed with the repeated measures analysis of variance and Tukey tests. Intergroup comparison was performed with t tests, 1-way analysis of variance, and Tukey tests. RESULTS: The E group had a longer treatment time than that of the NE group. In the pretreatment, posttreatment, and long-term posttreatment stages, the E and NE groups showed similar profile attractiveness. Laypersons and dentists were more critical than orthodontists. CONCLUSIONS: At long-term posttreatment follow-up, profile attractiveness was similar in patients treated with and without extractions.

Smile attractiveness in patients treated with or without 4 premolar extractions: A 36-year follow-up.

INTRODUCTION: This study aimed to assess the smile attractiveness in patients treated with or without 4 premolar extractions at a 36-year follow-up. METHODS: The sample comprised 52 patients with Class I and II malocclusion divided into 2 groups. Group 1 consisted of 15 patients treated without extractions (10 females and 5 males), with a mean pretreatment, posttreatment, and long-term posttreatment (T3) age of 13.2, 15.1, and 49.8 years, respectively. The mean treatment time was 1.9 years, and the mean long-term follow-up period was 34.7 years. Group 2 consisted of 37 patients (25 females and 12 males) treated with 4 premolar extractions, with a mean pretreatment, posttreatment, and long-term posttreatment age of 13.3, 15.7, and 53.6 years, respectively. The mean treatment time was 2.3 years, and the mean long-term follow-up period was 37.9 years. The mean retention time was 2 years for both groups. Frontal smiling photographs were obtained at long-term follow-up. Smile attractiveness was evaluated in an online questionnaire in which the evaluator could rate the smiling photographs with a 10-point scale. The randomly selected evaluator sample consisted of 62 laypeople, 33 dentists, and 89 orthodontists. Independent t tests, 1-way analysis of variance, and Tukey tests were used for intergroup comparisons at P <0.05. RESULTS: The smile attractiveness on the long term was similar in the groups treated with 4 premolar extractions (4.70 ± 1.35) or without extractions (4.51 ± 1.46). Women and orthodontists were more critical in assessing smile attractiveness than men, dentists, and laypeople. CONCLUSIONS: After long-term posttreatment, the smile attractiveness was similar in patients treated with 4 premolar extractions or without extractions.

Spectral Linear Mixing Model application in passive microwave data to analyze Antarctic surface melting dynamics (1978-2018).

Several studies have utilized passive microwave imagery for monitoring snowmelt in Antarctica. However, due to the low spatial resolution of these images (25 km), the quantification of snowmelt is not precise. To enhance the accuracy of these estimations, this study proposed a subpixel analysis approach based on a Spectral Linear Mixing Model. This approach was applied to images obtained from channels 18/19 GHz and 37 GHz, both horizontally and vertically polarized, acquired from the Scanning Multichannel Microwave Radiometer (SMMR), Special Sensor Microwave Imager (SSM/I), and Special Sensor Microwave Imager/Sounder (SSM/IS) instruments, spanning the period 1978-2018. The spatiotemporal analysis of the estimated snowmelt fraction images indicated that the most persistent and intensive melt was observed on the Antarctic Peninsula, particularly on the Larsen, Wilkins, George VI, and Wordie ice shelves. The melting period in the Antarctic Peninsula began in late October, with a peak in early January, and ended in late March. Other regions with persistent and intensive snowmelt were Mary Bird Land and Wilkes Land, followed by Dronning Maud Land, Amery Ice Shelf, Filchner-Ronne Ice Shelf, and Ross Ice Shelf. These snowmelt data are valuable for modeling the impacts of snowmelt on glacial systems, local coastal environments, and sea-level rise.

Concentration and thickness of sea ice in the Weddell Sea from SSM/I passive microwave radiometer data.

This study evaluated feasibility statistically and analyzed, during the freezing period, the relationship between brightness temperature (Tb) data of the 37V polarisation and the GR3719 (Gradient Ratio 37V and 19V) obtained by Special Sensor Microwave/Imager from F11 and F13 satellites with sea ice thickness (SIT) data obtained in the Weddell Sea through Antarctic Sea Ice Processes and Climate program. The multiple linear regression (MLR) was applied at 1,520 points, with 70% of these points being randomly separated to generate the MLR and 30% to carry out the validation. To perform the temporal mapping, the MLR was applied only to pixels with sea ice concentration (SIC) ≥ 90%, obtained through the fraction image calculated from the spectral linear mixing model (SLMM) using the Tb in the channels and polarizations 19H, 19V and 37V. The results of the SLMM validation process for estimating the SIC were σ = 10.5%, RMSE = 11.0%, and bias = -2.8%, and the SIT based on the MLR, the results were R² = 0.57, RMSE = 0.268 m, and bias = 0.103 m. In the SIT mapping, we highlight the trend of thickness reduction on the east coast of the Antarctic Peninsula during the period 1992-2009.

Snowmelt retrieval algorithm for the Antarctic Peninsula using SAR imageries.

The classification of Synthetic Aperture Radar (SAR) images by knowledge-based algorithms with elevation and backscatter thresholds were used in several studies to detect the Wet Snow Radar Zone (WSZ) in the Antarctic Peninsula. To identify it more accurately based on its seasonal variations, this study proposed the additional use of a threshold in synthetic images, created by rationing summer and winter sigma linear images. In our algorithm we used the following thresholds to detect the WSZ in Envisat ASAR imageries, using the Radarsat Antarctic Map Digital Elevation Model as ancillary data: i) -25 dB < s0 < -14 dB; ii) slinear summer / slinear winter < 0.4; iii) elevation H < 1,200 m for northern tip and H < 800 m for southern tip of the Antarctic Peninsula. The classified images were post-processed by a focal majority 5 x 5 filter and superimposed by an image of rock outcrops derived from the Antarctic Digital Database. The ratio image threshold allowed discriminating the WSZ from the Dry Snow Radar Zone and radar shadows, as well as transitional areas between this glacier zone and the Frozen Percolation Radar Zone, which would be classified incorrectly if we used only elevation and backscatter thresholds.

Comparative life cycle assessment of three 2030 scenarios of the Brazilian cement industry.

The cement industry is intensive in energy and feedstock use. It includes three main phases: raw materials and energy supply, transport, and manufacturing. The sector is known for its considerable environmental impacts. The increase in energy efficiency and the use of non-fossil fuels and raw materials are considered mature technologies in cement industries. We evaluate different environmental impacts of the production of 1 t of cement in four Brazilian scenarios. We compare one business-as-usual reference scenario (case 1) to three alternative 2030 carbon mitigation sectoral plan scenarios (cases 2, 3a, and 3b) that assume mature technologies. We analyze all 18 impact categories within the ReCiPe 2016 Life Cycle Assessment methodology. Results show reductions in 17 impact categories, ranging from no change in ozone depletion (case 2) to 39% reduction in fossil resource scarcity (case 3b). The effects on climate change decreased 14% in case 2 and 33% in cases 3a and 3b. The clinkerization process is the greatest contributor to atmospheric impacts, while raw material consumption to toxicity impacts. In contrast, there is no single main process contributing to resource depletion impacts. The changes in cement production lead to carbon emission reductions above expected levels and to reductions in other environmental impact categories modeled in ReCiPe 2016 method.

Pretreatment dentoskeletal comparison between individuals treated with extractions in the 1970s and in the new millennium.

OBJECTIVE: This retrospective study aimed to compare the occlusal and dentoskeletal initial features of patients treated with four first premolar extractions in the 1970s and after 2000. MATERIALS AND METHODS: Group 70' was composed by 30 subjects with Class I malocclusion (mean age of 12.8 years, 10 male, 20 female) treated in the 1970s with four first premolar extractions and comprehensive orthodontic treatment. Group NM comprised 30 subjects with Class I malocclusion (mean age of 13.4 years, 13 male, 17 female) treated in the new millennium, similarly to Group 70'. Initial dental models and lateral cephalograms were digitized and measured using OrthoAnalyzerTM 3D software and Dolphin Imaging 11.0 software, respectively. Initial occlusal and dentoskeletal features were analyzed and compared. Intergroup comparison was performed using t tests (p < 0.05). Holm-Bonferroni correction for multiple comparison was applied. RESULTS: Group NM showed significantly greater maxillary and mandibular effective lengths and greater maxillary and mandibular incisor protrusion in comparison with Group 70'. Group NM presented a significantly greater lower anterior facial height. Group NM also showed significantly smaller nasolabial angle and protruded inferior lip. CONCLUSION: Patients with Class I malocclusion treated with four first premolar extractions in the new millennium present a greater degree of dental and labial protrusion, increased lower anterior facial height, and more acute nasolabial angle compared with patients treated similarly in the 1970s. Greater dental and labial protrusion determines first premolar extractions in the new millennium. CLINICAL RELEVANCE: Despite the decrease of tooth extraction frequency, four first premolar extractions may be justified in cases with severe dental and skeletal protrusions.

Occlusal changes in orthodontically treated subjects 40 years after treatment and comparison with untreated control subjects.

INTRODUCTION: The objective of this study was to compare the aging changes of the dental arches in orthodontically treated and untreated subjects after a 4-decade follow-up period. METHODS: This retrospective study analyzed 2 groups. The treated group comprised 29 patients (11 male, 18 female) presenting with Class I or Class II malocclusions orthodontically treated with extractions of 4 first premolars. Dental models taken at pretreatment (12.84 years), posttreatment (14.95 years), and long-term posttreatment (51.37 years) were evaluated. The untreated (control) group consisted of 22 untreated patients with dental models taken at 13.32, 17.82, and 60.95 years of age. The dental models were digitized, and the following variables were evaluated: Little irregularity index, intercanine, interpremolar and intermolar widths, arch length, arch perimeter, overjet, and overbite. Interphase comparison of the treated group was performed with repeated measures analysis of variance and Tukey tests. Intergroup comparisons were performed using t tests (P <0.05). RESULTS: Crowding was corrected with treatment but relapsed significantly in the long term. Intercanine width increased with treatment and decreased in the long term. Interpremolar and intermolar widths, arch perimeter, and length decreased with treatment and continued to decrease long-term posttreatment. Overjet and overbite were corrected with treatment and remained stable in the long term. From posttreatment to long-term posttreatment, a greater crowding increase was observed in the treated group than in the untreated group. The treated group demonstrated a greater decrease in mandibular intercanine and maxillary and mandibular interpremolar widths than the untreated sample. Overbite increased in the treated group and decreased in the untreated group. The multiple regression analysis showed that previous 4-premolar extractions orthodontic treatment is significantly associated with anterior crowding in the long term. CONCLUSIONS: In the long-term, the treated patients showed relapse of crowding and a decrease in arch form. Long-term changes of treated patients were different from untreated subjects. Relapse might have contributed to greater changes in incisor crowding and arch widths observed in the treated patients.

Statistical modeling of sea ice concentration in the northwest region of the Antarctic Peninsula.

Sea ice is one of the main components of the cryosphere that modifies the exchange of heat and moisture between the ocean and atmosphere, regulating the global climate. In this sense, it is important to identify the concentration of sea ice in different regions of Antarctica in order to measure the impact of environmental changes on the region's ecosystem. The objective of this study was to evaluate the performance of the multiple linear regression and Box-Jenkins methods for predicting the concentration of sea ice along the northwest coast of the Antarctic Peninsula. Sea ice concentration data from May to November for the period 1979-2018 were extracted from passive remote sensors including a scanning multichannel microwave radiometer, special sensor microwave imager, and special sensor microwave imager/sounder. Meteorological variables from the atmospheric reanalysis model ERA5 of the European Center for Medium-Range Weather Forecasts were used as predictor variables, and the leave-one-out cross-validation technique was used to calibrate and validate the models. It was found that both statistical models have similar performance when analyzing residual analysis results, root mean square error of cross-validation, and final accuracy and residual standard deviation, these responses being related to the regionalization of the study area and to the Box-Jenkins presents strong, homogeneous, and stable correlations in the time series modeled for each pixel.

Two-phase orthodontic treatment of two different types of tooth transposition in the same patient.

Orthodontic treatment is thoroughly planned considering the patient's facial and dental characteristics, the main complaint, treatment time and the orthodontist's experience. Transposition is a form of ectopia, in which two adjacent teeth exchange positions in the dental arch. Transposition can be partial or complete. This article reports the treatment of a female patient with two kinds of tooth transposition managed in the mixed and permanent dentitions. A girl, aged eight years and three months, came to routine paediatric consultation with an ectopic permanent mandibular left lateral incisor in the mixed dentition. Radiographic analysis indicated partial transposition of the permanent mandibular left lateral incisor and canine (Md.L2.C), and development of a complete tooth transposition between the permanent maxillary right first pre-molar and canine (Mx.C.P1). The patient was treated in two phases. The first, in the mixed dentition, and the second, in the permanent dentition with a three-year follow-up between them. These challenging treatment approaches are described in detail, including the mechanics used. The key points of this treatment were early diagnosis of the ectopic mandibular lateral incisor, use of light forces and interphase patient follow-up. These determined the best time to start the second treatment phase, enabling achievement of aesthetic and functional outcomes, and the results remained stable one year after the end of orthodontic treatment.

Smile attractiveness in cases treated with self-ligating and conventional appliances with and without rapid maxillary expansion.

OBJECTIVE: This study aimed to compare the smile attractiveness after non-extraction treatment with self-ligating and rapid maxillary expansion (RME), to compare it to a control group treat with conventional fixed appliances and to evaluate the influence of buccal and posterior corridor areas in smile aesthetics. SETTINGS AND SAMPLE POPULATION: The sample consisted of frontal posed smile photographs of patients treated with self-ligating and conventional appliances with and without RME. MATERIAL AND METHODS: G1-treated with Damon self-ligating system (n = 20), G2-treated with RME and conventional fixed appliances (n = 22) and G3-treated only with conventional fixed appliances (n = 20). A website was created to provide an easy and quick evaluation of the smiles. The evaluators consisted of 70 orthodontists and 55 laypeople. Buccal and posterior corridors areas of each photograph were delimited in Photoshop CS3 and measured in AutoCAD in proportion to the total smile area. One- and two-way ANOVA were used for intergroup comparisons, and correlations were investigated with Pearson's correlation coefficient. RESULTS: There were no significant intergroup differences in smile attractiveness and in buccal and posterior corridor areas. There was no significant correlation between corridor areas and smile attractiveness. CONCLUSIONS: Smile attractiveness and areas of buccal and posterior corridors were similar in groups treated with self-ligating and conventional appliances with and without rapid maxillary expansion.

Evaluation of the influence of mandibular third molars on mandibular anterior crowding relapse.

Objective: To evaluate the influence of mandibular third molars on relapse of mandibular anterior crowding in orthodontically treated patients.Material and Methods: Sample included orthodontic records of 108 patients: Group 1: 72 patients (39 female; 33 male) with third molars present in the postretention evaluation stage. Group 2: 36 patients (18 female; 18 male) who did not present the third molars in the postretention evaluation stage. Panoramic radiographs and dental models were evaluated at three different stages: pre-treatment; posttreatment and postretention. Panoramic radiographs showed the presence or absence of third molars in the 3 evaluated stages and on the dental models, overbite and mandibular anterior crowding was measured by the Little Irregularity Index. For intergroup comparisons, t-tests and a multifactorial regression analysis were used.Results: There was no statistically significant difference in the relapse of mandibular anterior crowding among the groups with and without mandibular third molars at the postretention stage.Conclusion: The presence or absence of mandibular third molars did not influence the relapse of mandibular anterior crowding in orthodontically treated patients.

Long-term occlusal changes and patient satisfaction in patients treated with and without extractions: 37 years after treatment.

INTRODUCTION: The objective of this research was to evaluate the treatment outcomes, long-term occlusal changes, and patient satisfaction after 37 years of nonextraction and extraction treatments. METHODS: Fifty-seven patients with Class I and Class II malocclusion were divided into 2 groups. Group 1 included 16 patients treated with nonextraction therapy, with mean initial (T1), final (T2), and long-term posttreatment (T3) ages of 13.2, 15.0, and 50.3 years, respectively. Mean treatment time (T2 - T1) and long-term follow-up time (T3 - T2) were 1.8 and 35.2 years, respectively. Group 2 included 41 patients treated with extraction of 4 first premolars, with mean ages at T1, T2, and T3 of 13.3, 15.6, and 53.6 years, respectively. Mean treatment (T2 - T1) and long-term follow-up (T3 - T2) times were 2.3 and 37.9 years, respectively. The Peer Assessment Rating (PAR) index and Objective Grading System (OGS) indexes were evaluated at T1, T2, and T3 stages. The subjects also answered an online questionnaire regarding esthetic and occlusal self-perception at T3. Intergroup comparison was performed with t tests. RESULTS: The PAR index improved with treatment and similarly worsened at T3 for both groups. OGS scores were close to the passing score at T2 for both groups. The nonextraction group presented worse OGS scores at T3 than the extraction group. Nonextraction patients perceived more changes in alignment over time, but overall satisfaction was similar. CONCLUSIONS: The PAR index improved with treatment, and the PAR and OGS scores showed a significant increase, indicating great occlusal changes in the long-term stage. The nonextraction group showed more occlusal changes and perceived more changes in their alignment over time, but overall patient satisfaction was similar in both groups.

Anterior tooth alignment and arch dimensions changes: 37-year follow-up in patients treated with and without premolar extraction.

INTRODUCTION: The objective of this research was to evaluate the anterior tooth alignment and dental arch dimension changes after orthodontic treatments with and without premolar extractions in the long-term. METHODS: Fifty-seven patients with Class I and Class II malocclusion were divided into 2 groups. Group 1 included 16 patients treated with nonextraction therapy, with mean initial (T1), final (T2), and long-term follow-up (T3) ages of 13.20 years, 15.07 years, and 50.32 years, respectively. The mean treatment (T2 - T1) and long-term follow-up (T3 - T2) times were 1.86 years and 35.25 years, respectively. Group 2 included 41 patients treated with extraction of 4 first premolars, with T1, T2, and T3 ages of 13.31 years, 15.63 years, and 53.60 years, respectively. The mean treatment and long-term follow-up times were 2.32 years and 37.96 years, respectively. The mean retention time was 2.26 years for both groups. The dental casts were obtained and digitized at T1, T2, and T3 stages. The following measurements were obtained: Little irregularity index, arch length, perimeter, and intercanine, interpremolar, and intermolar widths. Intragroup and intergroup comparisons were performed with repeated measures analysis of variance and t tests, respectively. RESULTS: Anterior tooth irregularity index increased at T3 in both groups. In addition, all arch dimensions, except the intercanine width, were significantly smaller in the extraction group at T3. Both groups showed similar arch dimension changes at T3, except for the mandibular arch perimeter. The percentage of mandibular anterior tooth alignment change was significantly greater in the nonextraction than in the extraction group. CONCLUSIONS: There was no difference in the changes of anterior alignment and transverse arch dimensions in patients treated with and without premolar extraction at T3, but the percentage of mandibular anterior tooth alignment changes was higher in the nonextraction than in the extraction patients at T3. The mandibular arch perimeter showed more of a decrease at T3 in extraction patients.

Dental inclination with self-ligating and conventional fixed appliances, with and without rapid maxillary expansion.

OBJECTIVE: To compare the labio- and buccolingual inclination of the anterior and posterior teeth in subjects treated with self-ligating and conventional fixed appliances with and without rapid maxillary expansion. METHODS: Seventy-one subjects with Class I malocclusion were divided into three groups. Group 1 comprised 24 subjects (17 female; seven male, with a mean age of 13.94 ± 2.87 years), treated with Roth's pre-adjusted fixed appliances. Group 2 comprised 24 subjects (14 female; 10 male, with a mean age of 13.85 ± 1.83 years) treated with Rapid Maxillary Expansion followed by Roth's pre-adjusted fixed appliances. Group 3 comprised 23 patients (12 female; 11 male, with a mean age of 14.75 ± 1.34 years) treated with Damon self-ligating bracket system. Buccolingual inclination was measured on digital dental models using a 3D software. Intergroup changes comparison was performed with one-way ANOVA, followed by Tukey tests. RESULTS: The left maxillary lateral incisor showed labial inclination in the conventional and RME groups, and palatal inclination in the Damon group. The Damon group showed greater buccal inclination in most posterior mandibular teeth during treatment than the conventional and RME groups. The right mandibular canine and lateral incisor showed greater labial inclination in the Damon group than in the RME group. CONCLUSIONS: There was greater buccal inclination of the posterior mandibular teeth and labial inclination of the right mandibular canine and lateral incisor in the Damon group.

Aging of the normal occlusion.

OBJECTIVES: The aim of this study was to evaluate the qualitative occlusal changes in individuals with normal occlusion during a period of 47 years. MATERIALS AND METHODS: The sample comprised dental models of 20 subjects with normal occlusion (8 males; 12 females) taken at 13.2 years (T1) and 60.9 years of age (T2). The occlusal features were evaluated with the objective grading system (OGS) and with the six keys to normal occlusion (SKNO). The subjects also answered a questionnaire on the aesthetic and occlusal self-perception at T2. Comparisons from T1 to T2 were performed with paired t- and McNemar tests (P less than 0.05). RESULTS: OGS analysis showed a significant improvement in the marginal ridge levelling and tooth buccolingual inclination. There was a significant deterioration of the antero-posterior occlusal relationship from T1 to T2. Subjects without tooth loss showed a dental alignment worsening between time points. The marginal ridges, buccolingual inclination, and interproximal contacts improved. The SKNO analysis showed a significant deterioration of the maxillary second molars buccolingual inclination and an improvement of the maxillary second molar angulation. All patients were satisfied with their smiles, and 60 per cent of the subjects had no complaints. Dental crowding caused dissatisfaction in 35 per cent of the sample. LIMITATIONS: A limitation of this study was the high prevalence of tooth loss in the sample from T1 to T2. Only 30 per cent of the subjects had no tooth loss in T2. CONCLUSIONS: The aging process slightly deteriorates some occlusal features of individuals with normal occlusion. However, most individuals were satisfied with their aesthetics and occlusal comfort at the sixth decade of life.

Effect of Remote Ischemic Preconditioning on Systemic Toxicity and Ototoxicity Induced by Cisplatin in Rats: Role of TNF-α and Nitric Oxide.

BACKGROUND/AIMS: Cisplatin is a chemotherapeutic agent. The use of remote ischemic preconditioning (RIPC) was proposed after the observation that ischemic preconditioning of a cardiac vascular area could protect another completely distinctly. METHODS: This is an experimental study. Male Wistar rats were anesthetized, and they underwent a hearing evaluation via measurement of the brainstem auditory evoked potential (BSAEP). Then, cisplatin was administered intraperitoneally (IP) at a dose of 8 mg/kg/day for 4 consecutive days to group 1, whereas saline solution was administered IP to group 2. In groups 3 and 4, ischemia of the right hind paw was performed for 10 min, followed by reperfusion for 30 min, after which cisplatin or saline was administered IP to group 3 or group 4, respectively. Afterwards, all animals were evaluated via the BSAEP. The right cochlea was dissected for immunohistochemistry. RESULTS: RIPC lowered the increase in BSAEP of the animals treated with cisplatin (p = 0.0146). Weight loss decreased in the animals subjected to RIPC (p < 0.005). In group 3, RIPC reversed immunostaining for tumor necrosis factor-α and inducible nitric oxide synthase in the stria vascularis injured by cisplatin (p < 0.05). CONCLUSION: RIPC protects against systemic toxicity and ototoxicity induced by cisplatin in rats.

Relapse of anterior crowding 3 and 33 years postretention.

INTRODUCTION: The aim of this study was to evaluate the relapse of occlusal characteristics and maxillary and mandibular anterior crowding 3 and 33 years postretention. METHODS: The sample comprised 28 patients, 15 Class I and 13 Class II, treated with 4 premolar extractions, with a mean initial age of 12.72 years (SD, 0.99), a mean final age of 14.74 years (SD, 1.26), and a mean treatment time of 2.02 years (SD, 0.66). The mean short-term postretention age was 20.15 years (SD, 1.34), and the mean long-term postretention age was 49.40 years (SD, 4.54). The mean time of short-term postretention evaluation was 3.70 years (SD, 0.87) and the mean long-term postretention evaluation was 32.95 years (SD, 4.31). The maxillary and mandibular irregularity indexes were assessed on the initial, final, short-term, and long-term postretention stage dental casts. Peer Assessment Rating and the Little indexes were compared among the 4 stages by repeated measures analysis of variance and Tukey tests. RESULTS: Peer Assessment Rating index and maxillary anterior crowding were significantly improved with treatment, had significant relapses in the short term, and a slight and not statistically significant increase from short-term to long-term postretention evaluation. The mandibular irregularity index significantly decreased with treatment, and then significantly and progressively increased in the postretention stages. CONCLUSIONS: The occlusal characteristics and maxillary anterior crowding had significant relapses in the short term and remained stable from the short-term to the long-term postretention stages. Mandibular anterior crowding significantly decreased with treatment, showed a significant relapse in the short term, and continued to significantly increase in the long-term postretention stage.