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Proc Natl Acad Sci U S A ; 99(5): 3222-7, 2002 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-11854464

RESUMO

More chemicals can be smelled than there are olfactory receptors for them, necessitating a combinatorial representation by somewhat broadly tuned receptors. To understand the perception of odor quality and concentration, it is essential to establish the nature of the receptor repertoires that are activated by particular odorants at particular concentrations. We have taken advantage of the one-to-one correspondence of glomeruli and olfactory receptor molecules in the mouse olfactory bulb to analyze the tuning properties of a major receptor population by high resolution calcium imaging of odor responses selectively in the presynaptic compartment of glomeruli. We show that eighty different olfactory receptors projecting to the dorsal olfactory bulb respond to high concentrations of aldehydes with limited specificity. Varying ensembles of about 10 to 20 receptors encode any particular aldehyde at low stimulus concentrations with high specificity. Even normalized odor response patterns are markedly concentration dependent, caused by pronounced differences in affinity within the aldehyde receptor repertoire.


Assuntos
Odorantes , Bulbo Olfatório/fisiologia , Terminações Pré-Sinápticas/fisiologia , Aldeídos , Animais , Camundongos , Camundongos Endogâmicos C57BL
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