Detalhe da pesquisa
1.
Factors That Can Prolong Ocular Treatment Duration in Age-Related Macular Degeneration.
Ophthalmic Res
; 66(1): 653-663, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36626895
2.
A human blood-arachnoid barrier atlas of transporters, receptors, enzymes, and tight junction and marker proteins: Comparison with dog and pig in absolute abundance.
J Neurochem
; 161(2): 187-208, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35226354
3.
Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs.
Pharm Res
; 39(7): 1393-1413, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35488144
4.
Ocular and systemic pharmacokinetics of BI-X, a nanobody targeting VEGF and Ang-2, after intravitreal dosing in cynomolgus monkeys - Evidence for half-life extension by albumin.
Exp Eye Res
; 205: 108486, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33571529
5.
The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.
J Pharmacol Exp Ther
; 371(3): 633-641, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31578258
6.
Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates.
Mol Pharm
; 14(10): 3436-3447, 2017 10 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28880093
7.
Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.
Drug Metab Dispos
; 42(10): 1761-5, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25053619
8.
The Injection of Gels Through an Intact Annulus Maintains Biomechanical Performance without Extrusion Risk.
Gels
; 10(4)2024 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38667688
9.
A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study.
Pharmaceuticals (Basel)
; 17(2)2024 Jan 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38399408
10.
Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases.
Transl Vis Sci Technol
; 11(5): 18, 2022 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35579886
11.
Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes.
Sci Rep
; 12(1): 19395, 2022 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36371417
12.
AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice.
Transl Vis Sci Technol
; 10(11): 15, 2021 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34520511
13.
Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy.
Pharmaceutics
; 13(8)2021 Jul 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34452066
14.
Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans.
J Pharm Pharmacol
; 61(1): 55-62, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19126297
15.
Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats.
Biopharm Drug Dispos
; 30(5): 229-40, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19562682
16.
Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356)--investigations in DPP-4 deficient and wildtype rats.
Biopharm Drug Dispos
; 30(8): 422-36, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19771584
17.
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 50(26): 6450-3, 2007 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18052023
18.
Binding to Ocular Albumin as a Half-Life Extension Principle for Intravitreally Injected Drugs: Evidence from Mechanistic Rat and Rabbit Studies.
J Ocul Pharmacol Ther
; 33(2): 115-122, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28055308
19.
Effects of physiological and pharmacological stimuli on dopamine release in the rat globus pallidus.
Neurochem Int
; 47(7): 474-81, 2005 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16122838
20.
Single-stage debridement and spinal fusion using PEEK cages through a posterior approach for eradication of lumbar pyogenic spondylodiscitis: a safe treatment strategy for a detrimental condition.
Patient Saf Surg
; 9: 35, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26561500