Delirium Phenotype by Age and Sex in a Pooled Data Set of Adult Patients.

The authors aimed to evaluate whether the clinical phenotype of delirium differs if dichotomized either by sex or age (cutoff age, 65 years old) in a pooled sample of 406 nondemented adult patients with delirium as defined by DSM-IV criteria. Delirium characteristics were measured with the Delirium Rating Scale-Revised-98 (DRS-R-98). DRS-R-98 items were subgrouped to represent subscores representing the three core domains of delirium (cognitive, higher-order thinking, and circadian), noncore accessory symptoms (psychotic and affective), and diagnostic characteristics (temporal onset, fluctuation, and physical disorder). The authors compared means of the DRS-R-98 subscores and medians of individual items. Exploratory factor analyses evaluated delirium characteristics for each subgroup for each of the four groups-male, female, nongeriatric, and geriatric-while taking into account active medical diagnoses. Males had higher scores on motor agitation and affective lability (behavioral), whereas females had a higher frequency of hypoactive delirium. Delirium had a two-factor structure that emerged in all four study groups, and all its core domains loaded (i.e., correlated together) onto some of these two factors and with circadian domain correlating with accessory symptoms. Although the influence of a variety of active diagnoses on delirium was small and complex, traumatic brain injury had a clear influence on cognitive domain and abrupt onset. Age had a mild influence over delirium characteristics for both males and females. In conclusion, the authors confirmed a two-factor structure for delirium phenomenology, regardless of age and sex, with few significant differences between etiological groups.

Confirmatory Factor Analysis of the Delirium Rating Scale Revised-98 (DRS-R98).

Principal components analysis applied to the Delirium Rating Scale-Revised-98 contributes to understanding the delirium construct. Using a multisite pooled international delirium database, the authors applied confirmatory factor analysis to Delirium Rating Scale-Revised-98 scores from 859 adult patients evaluated by delirium experts (delirium, N=516; nondelirium, N=343). Confirmatory factor analysis found all diagnostic features and core symptoms (cognitive, language, thought process, sleep-wake cycle, motor retardation), except motor agitation, loaded onto factor 1. Motor agitation loaded onto factor 2 with noncore symptoms (delusions, affective lability, and perceptual disturbances). Factor 1 loading supports delirium as a single construct, but when accompanied by psychosis, motor agitation's role may not be solely as a circadian activity indicator.

Three core domains of delirium validated using exploratory and confirmatory factor analyses.

OBJECTIVE: To confirm the existence of the proposed three-core symptom domains in delirium by analyzing a dataset of nondemented adults using selected core symptoms as measured by the Delirium Rating Scale-Revised-98 (DRS-R98) scale. METHODS: Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) of proposed delirium core symptoms were conducted in a pooled international dataset of 592 delirious and nondelirious patients using DSM-IV criteria from 14 studies with comparable methodologies. Using DRS-R98 categorization, 445 had either subsyndromal or full delirium and comprised the delirium group. The dataset was divided into three independent random subsamples to perform a stepwise analysis. First we performed EFA in 100 cases to delineate latent factor loadings of DRS-R98 items selected to represent the three-core domains (circadian, higher level thinking, and cognitive). These items were then assessed using CFA-modeling (n = 246) followed by a CFA-validation (n = 246). Reliability and goodness of fit of these two CFA were assessed statistically. RESULTS: DRS-R98 items representing the proposed delirium core symptoms loaded onto one factor in the EFA, supporting their core nature. The two CFA confirmed the nature of this core factor as comprising three core domains where DRS-R98 items each loaded with high values (>0.7) onto their corresponding core domain (circadian, higher level thinking, and cognitive) with good fit and reliability. Attention was DRS-R98 item with the highest loading in CFA, followed by thought process, and then by sleep-wake cycle and motor behavior. CONCLUSIONS: Our EFA and CFA confirm and validate the proposed three-core domains of delirium, where symptoms were highly related to the domain that they were hypothesized to represent. These domains are consistent with delirium being a state of impaired consciousness, and should be considered necessary to assess whether in clinical or research settings.

Delusions and Hallucinations Are Associated With Greater Severity of Delirium.

BACKGROUND: The 3 core domains of delirium (cognitive, higher level thinking, circadian) do not include the less common noncore psychotic symptoms. However, psychosis might inform about perturbations of neural circuitry, outcomes, or suggest tailored clinical management. OBJECTIVE: We assessed relationships between psychosis and other characteristics of delirium in patients without dementia or antipsychotics treatment. METHODS: Cross-sectional analysis of 366 adults with delirium per the Delirium Rating Scale Revised-98, whose items distinguish hallucinations and delusions from other types of misperceptions and abnormal thought content, assessed during the preceding 24 hours to capture symptom severity fluctuation. The relationship of psychosis with other delirium characteristics was assessed using bivariate comparisons and analysis of variance as appropriate for groups with no psychosis and any psychosis (hallucinations and/or delusions), and subgroups with only hallucinations, only delusions, or both. A discriminant logistic model assessed variables associated with presence of any psychotic features versus none. RESULTS: Delirium with any psychotic features occurred in 44.5% (163 of 366). Of the 366, 119 (32.5%) had only hallucinations (Hall), 14 (3.8%) had only delusions (Del), and 30 (8.2%) had both (Both). In the psychotic group (n = 163), 73.0% were Hall, 8.6% Del, and 18.4% Both. All psychotic patient groupings had significantly greater delirium severity on the Delirium Rating Scale Revised-98. Delusions and hallucinations were discordant for occurring together. The discriminant model found increased odds of having psychosis as 3 symptom severities increased (visuospatial ability, thought process, and sleep-wake cycle) where these each represented a delirium core domain. The noncore symptom of lability of affect had high odds ratio for psychosis, while motor retardation reduced odds of psychosis in this model. CONCLUSIONS: Consistent with prior reports, psychosis occurred in less than half of delirious patients with delusions being infrequent, and an association with affective lability was found. Given that previous functional magnetic resonance imaging research found a correlation between neural network dysconnectivity with greater severity of delirium, psychotic symptoms might be a clinical marker for greater underlying cerebral cortical neural circuitry dysfunction.

The validity of the Beck Depression Inventory-Short Form as a screening and diagnostic instrument for moderate and severe depression in medical inpatients.

OBJECTIVE: To examine the concurrent validity of the Beck Depression Inventory-Short Form (BDI-SF) to detect moderate and severe depressive episodes according to the International Classification of Diseases, 10th edition (ICD-10) criteria in inpatients with heterogeneous medical conditions and to set cut-off scores for its use in medical wards. METHODS: One hundred and fifty-five patients [53% female; mean age (+/- S.D.) = 49.5 (+/- 17) years; mean number of years of education (+/- S.D.) = 6 (+/- 4) years] consecutively admitted to the adult medical wards in a General Hospital were interviewed during the first 72 h of hospitalization. The Clinical Interview Schedule [CIS] was used to make ICD-10 psychiatric diagnoses. All patients completed the BDI-SF. A "receiver operating characteristics" (ROC) curve was obtained and the sensitivity, specificity, positive and negative predictive values were calculated for different cut-off points of the BDI-SF. RESULTS: High sensitivity and negative predictive value (NPV) were obtained with a cut-off score of 9/10 (sensitivity = 100%, specificity = 83.1%, NPV = 100%). High sensitivity and positive predictive value (PPV) were obtained with a cut-off score of 13/14 (sensitivity = 93.5%, specificity = 96%, PPV = 85.3%). The area under the ROC curve was 98.4% (95% Confidence Interval = 0.97-1.00). CONCLUSIONS: The BDI-SF is a valid instrument for detecting moderate and severe depression in medical inpatients. For screening purposes, a 9/10 cut-off score is indicated, but if a high specificity is desired, a 13/14 cut-off score is warranted.

The impact of psychiatric comorbidity on length of stay of medical inpatients.

The aim of the study was to determine the impact of psychiatric comorbidity (PC) on length of hospital stay (LOS) of medical inpatients. A prospective cohort study was conducted. A series of 317 medical inpatients consecutively admitted to the general medical wards of a University Hospital composed the sample, after excluding those who refused or who could not be evaluated due to their physical illnesses or treatments (n=78). Data on demographic and medical variables were collected. A psychiatrist categorized subjects into two cohorts (with and without PC), according to DSM-IV, using the Schedule for Affective Disorders and Schizophrenia, except in patients cognitively impaired who were diagnosed by clinical interview. Mortality and length of stay during the index hospitalization were recorded. At admission, 156 (49%) inpatients had a current psychiatric comorbidity. After controlling for confounders (age and physical severity), in the multivariate analysis of covariance, the patients with cognitive impairment had a significantly prolonged LOS (F=17.8; P<.01) compared with those without cognitive impairment. No difference existed in LOS for the patients with depressive disorders (F=0.36; P=.55), Anxiety disorders (F=1.48; P=.22) or Substance related disorders (F=1.05; P=.30). These results suggest an independent effect of cognitive impairment increasing LOS of medical inpatients.

Phenotype of subsyndromal delirium using pooled multicultural Delirium Rating Scale--Revised-98 data.

OBJECTIVE: There is no consensus definition for the phenotype of subsyndromal delirium (SSD), a subthreshold state to full delirium. Without an a priori definition we applied advanced analytic techniques to discern SSD. METHOD: We pooled Delirium Rating Scale-Revised-98 (DRS-R98) data from 859 DSM-IV diagnosed nondemented delirious adults and nondelirious controls collected by investigators in 7 countries. Discriminant analyses defined an SSD group that was then compared to Nondelirium and Delirium groups. RESULTS: SSD (n=138) had intermediate DRS-R98 item severities between Delirium (n=497) and Nondelirium (n=224) groups, where groups significantly differed on all DRS-R98 items (ANOVA p<.001) except delusions. Discriminant analysis found SSD phenomenologically closer to Delirium than Nondelirium. Using full multinomial logistical regression, SSD was distinguished from Nondelirium by temporal onset, sleep-wake cycle, perceptual disturbances, motor retardation, delusion, affective lability, and all cognitive items; SSD was similar to Delirium in thought process, language, motor agitation or retardation, sleep-wake cycle, all cognitive items, fluctuation and physical disorder. The multivariate model correctly classified 94.2% of Nondelirium, 75.4% of SSD and 97.2% of Delirium subjects. Binary logistic regression of six core domain symptoms (sleep-wake cycle, thought process, language, attention, orientation, and visuospatial ability) together were found as highly differentiating of SSD from Nondelirium, which correctly classified almost 80% of SDD. CONCLUSIONS: SSD is intermediate in severity between nondelirious controls and full syndromal delirium, but its phenotype is more like delirium. Core domain delirium symptoms present at milder severity in SSD should be evaluated further for utility in detecting and managing SSD, preventing delirium, and possible inclusion in DSM-V.

Suicidal ideation in medical inpatients: psychosocial and clinical correlates.

OBJECTIVE: To identify psychosocial and clinical correlates of suicidal ideation in medical inpatients. METHOD: In a cross-sectional study, all adults consecutively admitted to the medical wards of a University Hospital had their names recorded and were randomized and evaluated during the first week of admission. Suicidal ideation was assessed using Item 9 of Patient Health Questionnaire-9. The Beck Depression Inventory, the Beck Anxiety Inventory, the WHO Subjective well-being scale, the Charlson Comorbidity Index and other numerical rating scales (pain and self-reported physical illness severity) were used. Patients with less than four confidants were considered with poor social support. The Student's t test, Mann-Whitney U test, chi-square test and stepwise logistic regression analysis were used. RESULTS: Of the 1092 patients who composed the sample, 7.2% reported having suicidal ideation. After adjusting for psychosocial and clinical confounders, prior suicide attempts (OR: 4.41; 95% CI: 2.12-9.15; P<.001), depressive symptoms (OR: 1.11; 95% CI: 1.06-1.17; P<.001), severe anxiety symptoms (OR: 3.04; 95% CI: 1.47-6.26; P=.003) and poor social support (OR: 2.02; 95% CI:1.03-3.96; P=.04) were independently associated with suicidal ideation. CONCLUSIONS: Three out of the four correlates of suicidal ideation in medical inpatients are potentially modifiable factors: severe anxiety, depressive symptoms and poor social support. The fourth variable, prior suicide attempts, is not modifiable but should serve as a red flag to suspect and investigate current suicide risk. These findings highlight the importance of suicidal ideation as a proxy for the distress that is incumbent upon physicians to manage if they wish to provide excellent and comprehensive inpatient care.

Portuguese version of the Delirium Rating Scale-Revised-98: reliability and validity.

OBJECTIVE: To assess the validity and the reliability of the Portuguese version of the Delirium Rating Scale-Revised-98 (DRS-R-98). METHODS: The scale was translated into Portuguese and back-translated into English. After assessing its face validity, five diagnostic groups (n=64; delirium, depression, dementia, schizophrenia and others) were evaluated by two independent researchers blinded to the diagnosis. Diagnosis and severity of delirium as measured by the DRS-R-98 were compared to clinical diagnosis, Mini-Mental State Exam, Confusion Assessment Method, and Clinical Global Impressions scale (CGI). RESULTS: Mean and median DRS-R-98 total scores significantly distinguished delirium from the other groups (p<0.001). Inter-rater reliability (ICC between 0.9 and 1) and internal consistency (alpha=0.91) were very high. DRS-R-98 severity scores correlated highly with the CGI. Mean DRS-R-98 severity scores during delirium differed significantly (p<0.01) from the post-treatment values. The area under the curve established by ROC analysis was 0.99 and using the cut-off value of 20 the scale showed sensitivity and specificity of 92.6% and 94.6%, respectively. CONCLUSION: The Portuguese version of the DRS-R-98 is a valid and reliable measure of delirium that distinguishes delirium from other disorders and is sensitive to change in delirium severity, which may be of great value for longitudinal studies.

Percepção e expressão de sintomas depressivos em três grupos culturais catarinenses: açorianos, italianos e alemães / Perceptions of the symptoms of depression between members of three ethnic communities in Santa Catarina: azoreans, italians and germans

OBJETIVOS: Comparar a percepção da depressão, incluindo a percepção dos sintomas e dos tratamentos considerados apropriados, pelos membros de três grupos étnicos (descendentes de açorianos, italianos e alemães residentes em Santa Catarina, Estado da Região Sul do Brasil), assim como a expressão de depressão por meio do Inventário Beck de Depressão nestes grupos. METÓDO: Em um estudo transversal, com uma parte quantitativa e uma qualitativa, foram avaliados 60 indivíduos, sendo 20 de cada uma das comunidades étnicas escolhidas: açoriana, italiana e alemã. Realizou-se uma entrevista semi-aberta, tendo como questões orientadoras: Para você, o que é depressão?; O que pessoas deprimidas devem fazer?; e Qual atividade de lazer você mais gosta de fazer? Depois, foi aplicado o Inventário Beck de Depressão (BDI). Os escores do BDI (subescalas: cognitiva-afetiva e somática) foram comparados entre os diferentes grupos por meio do método ANOVA. No estudo qualitativo, verificaram-se as percepções compartilhadas no discurso dos indivíduos de cada grupo, quanto à depressão e seu tratamento. RESULTADOS: Os principais sintomas relatados por descendência foram: irritabilidade (açorianos), autopunição (italianos) e falta de energia (alemães). Não houve diferença estatisticamente significativa quanto à freqüência de sintomas cognitivos e somáticos nas diferentes comunidades. O padrão de percepção da depressão caracterizou-se nos descendentes de açorianos por isolamento ("... a gente não quer ver ninguém"). Nos italianos, a depressão esteve relacionada a afastamento da família ("Depressão é vontade até de deixar o filho, o marido"), sendo esta vista como a responsável por ajudar na melhora. Já entre os alemães, a depressão esteve relacionada à dificuldade no trabalho ("Depressão é... não ter mais vontade de trabalhar") e este foi relatado como a solução. CONCLUSÃO: De acordo com o grupo étnico, a expressão, a percepção e a busca de tratamento para a depressão...

OBJECTIVES: To compare perceptions of the symptoms of depression and its management between members of three ethnic communities (descendants of Azoreans, Italians and Germans in Santa Catarina, which is a State in the South of Brazil) and to compare the expression of depressive symptoms via the Beck Depression Inventory. METHODS: In a cross-sectional study, with both a quantitative and a qualitative design, 60 individuals (20 of each of the above ethnicities) were interviewed. A semi-structured interview was conducted, oriented by the following questions: In your opinion, what is depression?; How should persons cope with depression? and What is your preferred leisure time activity? After that, the subjects completed the Beck Depression Inventory (BDI). The BDI scores (subscales: cognitive/affective and somatic) were compared among the three groups using ANOVA. In the qualitative study, patterns of perceptions concerning depression were identified analyzing the responses of the individuals to the semi-structured interviews. RESULTS: The most frequent self-reported symptoms according to each ethnicity were: irritability (Azoreans), self-punishment (Italians) and low energy (Germans). There were no statistically significant differences between cognitive or somatic scores among the groups. The Azorean descendants suspected depression if the individuals evidenced social withdrawal ("... we don't want to see anybody"). For the Italian descendants, the family was cited as important in detecting ("Depression is feeling like leaving your son, your husband") and managing depression. The German descendants attributed depression to difficulty with work ("Depression is... not wanting to work") and work was also seen as the solution. CONCLUSIONS: According to ethnicity, the detection, expression of symptoms and search for treatment was related to: the community (Azoreans); the family (Italians) and work (Germans).

Diagnosticando depressão em pacientes internados com doenças hematológicas: prevalência e sintomas associados / Diagnosing depression among hematological impatients: prevalence and associated symptons

Introdução: não encontramos estudos avaliando o diagnóstico e a prevalência de depressão em pacientes hematológicos aqui no Brasil. Objetivo: verificar a prevalência dos sintomas depressivos e quais deles mais se associam à depressão em pacientes internados com doenças hematológicas. Métodos: num estudo transversal, 104 pacientes consecutivamente internados nos leitos da hematologia do Hospital Universitário da Universidade Federal de Santa Catarina (HU/UFSC) foram avaliados. Foram preenchidos questionários de variáveis sociodemográficas e de história psiquiátrica. O índice Charlson de co-morbidade (IC) foi usado para medir gravidade física. Foi aplicado, também, o inventário Beck de depressão (BDI). Aqueles que tiveram pontuação acima de 9 na soma dos 13 primeiros itens do BDI(BDI-13) foram considerados deprimidos. Também foi verificada a freqüência caso fosse utilizada a escala completa com 21 itens (BDI-21), com ponto de corte 16/17. Resultados: as prevalências foram: BDI-13 = 25% e BDI-21 = 32,7%. Após controle para fatores de confusão, os sintomas que permaneceram no modelo de regressão logística, indicando que melhor detectavam os deprimidos, foram sensação de fracasso, anedonia, culpa e fadiga. Conclusão: cerca de um quarto a um terço dos pacientes internados com doenças hematológicas tinham sintomas depressivos significativos, e os sintomas que melhor os discriminaram foram sensação de fracasso, anedonia, culpa e fadiga.

Frequência de sintomas depressivos em pacientes com história de infarto agudo do miocárdio / Frequency of depressive symptoms in patients with previous history of myocardial infarction

Objetivo: Descrever a freqüência de sintomas depressivos autoðrelatados em pacientes com história de infarto agudo do miocárdio (IAM) internados nas Enfermarias de Clínica Médica (ECM) do Hospital Universitário da Universidade Federal de Santa Catarina (HUðUFSC). Método: Trataðse de um estudo de observação transversal no qual foram randomizados 752 pacientes internados nas ECM do HUðUFSC, no período de junho de 2000 a outubro de 2001. Destes, foram excluídos 120 devido a idade menor de 18 anos, incapacidade física, prejuízo congnitivo ou recusa. A amostra foi composta de 68 pacientes com história prévia de IAM detectada através do prontuário e de pergunta direta. Foram colhidos dados sociodemográficos e de história clínica. Foi utilizada a subescala cognitivoðafetiva (primeiros 13 itens) do Inventário Beck de Depressão (BDI), sendo considerados portadores de sintomas depressivos aqueles pacientes com escore maior que 10. Resultados: A amostra foi composta por 68 pacientes, sendo 82,4 por cento (n = 56) homens, 89,7 por cento (n = 61) da raça branca e 73,5 por cento (n = 50) casados. A média de idade ñ desvia padrão (DP) foi de 58,8 ñ 13,5 anos, e a média de escolaridade ñ DP foi de 5,7 ñ 3,7 anos. A freqüência de sintomas depressivos de acordo com a subescala cognitivoðafetiva do BDI foi de 32,2 por cento. Conclusão: Cerca de um terço dos pacientes internados nas ECM do HUðUFSC com história prévia de IAM apresentou sintomas depressivos