Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.

The EPICO (Spanish general registry of COVID-19 in children)-SEHOP (Spanish Society of Pediatric Hematology and Oncology) platform gathers data from children with SARS-CoV-2 in Spain, allowing comparison between children with cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) and those without. The infection is milder in the cancer/alloHSCT group than in children without comorbidities (7.1% vs. 14.7%), except in children with recent alloHSCT (less than 300 days), of which 35.7% experienced severe COVID-19. These data have been shared with the SEHOP members to support treatment and isolation policies akin to those for children without cancer, except for those with recent alloHSCT or additional comorbidities. This highlights the collaborative registries potential in managing pandemic emergencies.

Hipoxemia como única manifestación de hemoglobinopatía estructural / Hypoxemia as the only manifestation of structural hemoglobinopathy

Las hemoglobinopatías son resultado de mutaciones en los genes responsables de la estructura molecular de la hemoglobina. Tienen una expresividad clínica muy variable: desde mínimamente sintomáticas a patología grave. Presentamos el caso de un niño de tres años ingresado por una neumonía atípica con hipoxemia que, tras 11 días de ingreso, mantiene saturaciones periféricas de oxígeno (SpO) de 92-94% sin otra sintomatología, exploración física y estudio cardiopulmonar normal. En el seguimiento ambulatorio persiste la desaturación periférica con gasometría y cooximetría arterial normal. El padre del paciente presenta los mismos hallazgos tanto en la pulsioximetría como en la gasometría arterial. Ante la sospecha de una hemoglobinopatía estructural se realiza estudio genético y electroforético detectándose la presencia de hemoglobina Arta

Structural hemoglobinopathies are the result of gene mutations that cause alterations in the molecular structure of hemoglobin. They have a very variable clinical expression: from minimally symptomatic to severe pathology. We present the case of a 3-year-old boy admitted for atypical pneumonia with hypoxemia who, after 11 days of admission, maintained peripheral oxygen saturations (SpO) of 92-94% without other symptoms, physical examination and normal cardiopulmonary study. In outpatient follow-up, peripheral desaturation persists with gasometry and normal arterial co-oxymetry. Patient's father with the same findings in pulse oximetry as in arterial blood gases. When a structural hemoglobinopathy was suspected, a genetic and electrophoretic study was performed, detecting the presence of hemoglobin Arta