Hair dosimetry following neutron irradiation.

Use of hair as a biological dosimeter of neutron exposure was proposed a few years ago. To date, the (32)S(n,p)(32)P reaction in hair with a threshold of 2.5 MeV is the best choice to determine the fast neutron dose using body activation. This information is essential with regards to the heterogeneity of the neutron transfer to the organism. This is a very important parameter for individual dose reconstruction from the surface to the deeper tissues. This evaluation is essential to the adapted management of irradiated victims by specialized medical staff. Comparison exercises between clinical biochemistry laboratories from French sites (the CEA and COGEMA) and from the IRSN were carried out to validate the measurement of (32)P activity in hair and to improve the techniques used to perform this examination. Hair was placed on a phantom and was irradiated at different doses in the SILENE reactor (Valduc, France). Different parameters were tested: variation of hair type, minimum weight of hair sample, hair wash before measurement, delivery period of results, and different irradiation configurations. The results obtained in these comparison exercises by the different laboratories showed an excellent correlation. This allowed the assessment of a dose-activity relationship and confirmed the feasibility and the interest of (32)P measurement in hair following fast neutron irradiation.

Retrospective dosimetry after criticality accidents using low-frequency EPR: a study of whole human teeth irradiated in a mixed neutron and gamma-radiation field.

In the context of accidental or intentional radiation exposures (nuclear terrorism), it is essential to separate rapidly those individuals with substantial exposures from those with exposures that do not constitute an immediate threat to health. Low-frequency electron paramagnetic resonance (EPR) spectroscopy provides the potential advantage of making accurate and sensitive measurements of absorbed radiation dose in teeth without removing the teeth from the potential victims. Up to now, most studies focused on the dose-response curves obtained for gamma radiation. In radiation accidents, however, the contribution of neutrons to the total radiation dose should not be neglected. To determine how neutrons contribute to the apparent dose estimated by EPR dosimetry, extracted whole human teeth were irradiated at the SILENE reactor in a mixed neutron and gamma-radiation field simulating criticality accidents. The teeth were irradiated in free air as well as in a paraffin head phantom. Lead screens were also used to eliminate to a large extent the contribution of the gamma radiation to the dose received by the teeth. The EPR signals, obtained with a low-frequency (1.2 GHz) spectrometer, were compared to dosimetry measurements at the same location. The contribution of neutrons to the EPR dosimetric signal was negligible in the range of 0 to 10 Gy and was rather small (neutron/gamma-ray sensitivity in the range 0-0.2) at higher doses. This indicates that the method essentially provides information on the dose received from the gamma-ray component of the radiation.

Dose reconstruction by EPR spectroscopy of tooth enamel: application to the population of Zaborie village exposed to high radioactive contamination after the Chernobyl accident.

Individual irradiation doses were determined by electron paramagnetic resonance spectroscopy of the tooth enamel of the inhabitants of Zaborie, the most contaminated inhabited settlement not evacuated after the Chernobyl accident. Dose determination was performed using a specially developed automatic spectrum processing procedure. Spectrum processing was carried out in different operating modes, and average results were taken in order to reduce the contribution of uncertainty in dose determination caused by spectrum processing. The absorbed doses determined in enamel were corrected to take into account the contribution of natural background radiation and to determine the individual excess dose due to radioactive contamination of the territory. Individual excess doses are compared to calculated individualized doses to teeth, estimated using the local radioactive contamination levels, dose rates, and information concerning individual behavior. The individual excess doses measured by electron paramagnetic resonance spectroscopy and the calculated individualized doses are fully independent. Mean square variation between results of two methods was found to be 34 mGy, which is consistent with error estimation for both methods. This result can validate both the methodology of signal processing presented here when using electron paramagnetic resonance dosimetry of tooth enamel for low doses and the methodology of individualized dose calculation.

New approach for dose reconstruction: application to one case of localized irradiation with radiological burns.

When localized accidental irradiation occurs, it is necessary to determine the extent to which tissues and vital organs have been damaged, mainly in the vicinity of the source. At present, biological markers cannot be used to estimate the heterogeneity of the dose distribution. An alternative is to map the absorbed dose in the different regions of the body. Using a Monte Carlo calculation code, it is possible to simulate the accident while taking into account the specific morphology of the irradiated individual and his environment, as well as the source characteristics. The calculated values are matched to the clinical signs of the lesion, particularly around the rim of the radiation-induced necrosis. This technique was applied successfully on two patients who presented very severe lesions due to acute localized irradiation after an accident that occurred at Lilo (Georgia) in 1996-1997; only the most demonstrative case is presented here.

Optimisation of recording conditions for the electron paramagnetic resonance signal used in dental enamel dosimetry.

Optimisation of the parameters for recording the electron paramagnetic resonance (EPR) spectra of dental enamel for absorbed dose reconstruction was performed for an EMX (Bruker) spectrometer supplied with a high-sensitivity microwave cavity. Dose determination was performed using a previously developed automatic spectra processing procedure, which uses the non-linear fit of a model spectrum. The experimental error was estimated as the standard deviation of the results from the nominal doses for the set of spectra recorded for 10 samples prepared from teeth of different persons and irradiated in the dose range 0-500 mGy. The microwave power and magnetic field modulation amplitude corresponding to the minimum of dependencies of the error on these parameters were adopted as the optimal ones. For the sets of spectra recorded at optimal parameters for sample masses 100, 50 and 30 mg, the errors of dose determination were obtained as 18, 27 and 37 mGy respectively.