Detalhe da pesquisa
1.
Contribution of APOE Genetic Variants to Dyslipidemia.
Arterioscler Thromb Vasc Biol
; 43(6): 1066-1077, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37051929
2.
Predictive Modeling and Structure Analysis of Genetic Variants in Familial Hypercholesterolemia: Implications for Diagnosis and Protein Interaction Studies.
Curr Atheroscler Rep
; 25(11): 839-859, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37847331
3.
Leu22_Leu23 Duplication at the Signal Peptide of PCSK9 Promotes Intracellular Degradation of LDLr and Autosomal Dominant Hypercholesterolemia.
Arterioscler Thromb Vasc Biol
; 42(7): e203-e216, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35510551
4.
Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model.
Small
; 18(13): e2105915, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35156292
5.
Pathophysiology of Atherosclerosis.
Int J Mol Sci
; 23(6)2022 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35328769
6.
A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants.
Int J Mol Sci
; 22(24)2021 Dec 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34948399
7.
Pathophysiology of Type 2 Diabetes Mellitus.
Int J Mol Sci
; 21(17)2020 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32872570
8.
Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights.
Int J Mol Sci
; 21(13)2020 Jul 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32630698
9.
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression.
Int J Mol Sci
; 21(22)2020 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33212990
10.
Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease.
Int J Mol Sci
; 19(11)2018 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30388787
11.
Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants.
Int J Mol Sci
; 19(6)2018 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29874871
12.
OptiMo-LDLr: An Integrated In Silico Model with Enhanced Predictive Power for LDL Receptor Variants, Unraveling Hot Spot Pathogenic Residues.
Adv Sci (Weinh)
; 11(13): e2305177, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38258479
13.
LDLR variants functional characterization: Contribution to variant classification.
Atherosclerosis
; 329: 14-21, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34167030
14.
Molecular mechanisms of lipotoxicity-induced pancreatic ß-cell dysfunction.
Int Rev Cell Mol Biol
; 359: 357-402, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33832653
15.
MLb-LDLr: A Machine Learning Model for Predicting the Pathogenicity of LDLr Missense Variants.
JACC Basic Transl Sci
; 6(11): 815-827, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34869944
16.
Mutation type classification and pathogenicity assignment of sixteen missense variants located in the EGF-precursor homology domain of the LDLR.
Sci Rep
; 10(1): 1727, 2020 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32015373
17.
Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition.
Biomedicines
; 8(10)2020 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32977626
18.
The Arg499His gain-of-function mutation in the C-terminal domain of PCSK9.
Atherosclerosis
; 289: 162-172, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31518966