Detalhe da pesquisa
1.
Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
J Biol Chem
; 294(23): 9029-9036, 2019 06 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31018963
2.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36940470
3.
Lipophilic Efficiency as an Important Metric in Drug Design.
J Med Chem
; 61(15): 6401-6420, 2018 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29589935
4.
Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib.
ACS Med Chem Lett
; 9(9): 878-883, 2018 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30258534
5.
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
ACS Med Chem Lett
; 9(9): 872-877, 2018 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30258533