Detalhe da pesquisa
1.
Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.
Drug Metab Dispos
; 44(10): 1668-74, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27457784
2.
Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist.
Bioorg Med Chem Lett
; 21(5): 1442-6, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21295478
3.
Metabolism, excretion, and pharmacokinetics of [14C]INCB018424, a selective Janus tyrosine kinase 1/2 inhibitor, in humans.
Drug Metab Dispos
; 38(11): 2023-31, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20699411
4.
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 18(4): 1288-92, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18234496
5.
Asymmetric synthesis of the (S)-1,1-dioxido-isothiazolidin-3-one phosphotyrosine mimetic via reduction of a homochiral (R)-oxido-isothiazolidin-3-one.
Org Lett
; 9(7): 1279-82, 2007 Mar 29.
Artigo
Inglês
| MEDLINE | ID: mdl-17338536
6.
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
J Med Chem
; 48(21): 6544-8, 2005 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-16220970
7.
Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist.
ACS Med Chem Lett
; 2(6): 450-4, 2011 Jun 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24900329
8.
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.
ACS Med Chem Lett
; 1(9): 483-7, 2010 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24900235
9.
Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction.
Org Lett
; 11(9): 1999-2002, 2009 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-19385672