Detalhe da pesquisa
1.
Targeting androgen receptor phase separation to overcome antiandrogen resistance.
Nat Chem Biol
; 18(12): 1341-1350, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36229685
2.
Conformational plasticity of the 2A proteinase from enterovirus 71.
J Virol
; 87(13): 7348-56, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23616646
3.
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J Med Chem
; 65(7): 5317-5333, 2022 04 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35352560
4.
Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling.
BMC Pharmacol
; 10: 10, 2010 Aug 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20735854
5.
PDTD: a web-accessible protein database for drug target identification.
BMC Bioinformatics
; 9: 104, 2008 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-18282303
6.
TarFisDock: a web server for identifying drug targets with docking approach.
Nucleic Acids Res
; 34(Web Server issue): W219-24, 2006 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16844997
7.
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
PLoS One
; 12(1): e0169855, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28072869
8.
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
J Med Chem
; 60(6): 2215-2226, 2017 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-28092155
9.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
ACS Med Chem Lett
; 7(10): 896-901, 2016 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-27774125
10.
Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.
J Med Chem
; 55(16): 7037-53, 2012 Aug 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22862148
11.
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors.
Chem Pharm Bull (Tokyo)
; 56(10): 1400-5, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18827378
12.
Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma.
Biochem Pharmacol
; 75(6): 1381-92, 2008 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18164690