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Nanomedicine (Lond) ; 19(5): 397-412, 2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-38112257

RESUMO

Aim: This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. Materials & methods: A nanocomposite was synthesized (graphene oxide-polyethyleneimine-gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. Results: Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. Conclusion: This result points to prospective studies with the tested cell lines using tumor animal models.


Assuntos
Grafite , Nanocompostos , Animais , Estudos Prospectivos , Linhagem Celular Tumoral , Grafite/farmacologia , Nanocompostos/uso terapêutico
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