RESUMO
Two statistical experimental designs were used to investigate factors involved in 90-day mortality from secondary disease in lethally irradiated mice treated with rat bone marrow. Secondary disease is a graft-versus-host syndrome that has a mortality of about 65-95% in this transplant situation. When the factors--age-of-donor-cells, day-of-cell-injection, dose-of-marrow-cells, sex, and environment--were examined for their main effects and interactions, some combinations of these factors were found to give about 25% 90-day mortality. The experiments indicate that the lowest mortality can be achieved with an injection of 40 million or more cells 1 day after irradiation and an ultraclean environment of unlimited filter-top caging.
Assuntos
Transplante de Medula Óssea , Ambiente Controlado , Doença Enxerto-Hospedeiro/mortalidade , Modelos Estatísticos , Quimera por Radiação , Irradiação Corporal Total , Fatores Etários , Animais , Feminino , Masculino , Camundongos , Ratos , Fatores Sexuais , Fatores de Tempo , Irradiação Corporal Total/mortalidadeRESUMO
BACKGROUND: The most preventable causes of death in the hospitalized patient are deep vein thrombosis (DVT) and pulmonary embolism. Despite the long-term (> 15 years) availability of evidence-based consensus guidelines for prevention of venous thromboembolism, thromboprophylaxis remains underused. Improving staff and patient utilization of prophylactic treatment for postoperative patients reduces hospital-acquired venous thromboembolism and improves patient outcomes. Anecdotal evidence and observations of intermittent pneumatic compression (IPC) therapy utilization at the authors' institution suggested that ordered IPC therapy was not consistently in use with postsurgical patients. OBJECTIVES: We sought to increase the use of IPC devices by all staff on our hospital pilot units and to promote sustained use of IPC devices. METHODS: Multiple methodologies were employed to address this issue, including point prevalence audits, root-cause analyses, a nursing survey, and a pilot project on selected surgical units. RESULTS: Statistically significant improvements on the pilot units were achieved by implementing a 3-tier interventional plan. CONCLUSION: Our pilot project demonstrated that nurse education, patient education, and nurse attention to solving systems issues can significantly improve IPC use in surgical patients.