Detalhe da pesquisa
1.
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages.
Cell
; 151(3): 658-70, 2012 Oct 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23101632
2.
Design and preparation of N-linked hydroxypyridine-based APJ agonists.
Bioorg Med Chem Lett
; 73: 128882, 2022 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35817293
3.
Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists.
Bioorg Med Chem Lett
; 50: 128325, 2021 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34403724
4.
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.
Am J Hum Genet
; 100(3): 428-443, 2017 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28257690
5.
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.
Bioorg Med Chem Lett
; 30(7): 126955, 2020 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32035698
6.
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
Anal Biochem
; 568: 41-50, 2019 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30605634
7.
Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.
PLoS Genet
; 11(12): e1005711, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26694027
8.
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.
Hum Mol Genet
; 22(15): 3023-37, 2013 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23562819
9.
Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.
PLoS Genet
; 12(3): e1005913, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26934746
10.
Comparative analysis of proteome and transcriptome variation in mouse.
PLoS Genet
; 7(6): e1001393, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21695224
11.
Systems genetics analysis of gene-by-environment interactions in human cells.
Am J Hum Genet
; 86(3): 399-410, 2010 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-20170901
12.
A high-resolution association mapping panel for the dissection of complex traits in mice.
Genome Res
; 20(2): 281-90, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-20054062
13.
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.
Mamm Genome
; 23(9-10): 680-92, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22892838
14.
Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data.
Am J Cardiovasc Drugs
; 22(6): 615-631, 2022 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-35570249
15.
CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade.
J Immunol
; 182(1): 466-76, 2009 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19109178
16.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.
Circ Heart Fail
; 14(3): e007351, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33663236
17.
Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.
ACS Med Chem Lett
; 12(11): 1766-1772, 2021 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34795866
18.
Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.
J Med Chem
; 64(24): 18102-18113, 2021 12 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34855405
19.
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.
J Med Chem
; 64(6): 3086-3099, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33689340
20.
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response.
Blood
; 112(2): 330-9, 2008 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18451308