Detalhe da pesquisa
1.
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model.
J Neuroinflammation
; 20(1): 29, 2023 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36755323
2.
Central and Peripheral Inflammation in Mild Cognitive Impairment in the Context of Alzheimer's Disease.
Int J Mol Sci
; 24(13)2023 Jun 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37445700
3.
Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers.
Neuroimage
; 230: 117785, 2021 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33545349
4.
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.
Hum Mol Genet
; 27(12): 2039-2051, 2018 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29590342
5.
Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice.
Neuroimage
; 191: 392-402, 2019 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30807820
6.
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
PLoS Pathog
; 13(11): e1006733, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-29176838
7.
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes.
J Neuroinflammation
; 13(1): 189, 2016 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27549131
8.
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.
Hum Mol Genet
; 27(21): 3825, 2018 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30107584
9.
A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.
Mov Disord
; 30(3): 427-31, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25689146
10.
Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11 C]ABP688 PET imaging.
Synapse
; 68(12): 565-573, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25098663
11.
AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization.
Bioorg Med Chem
; 22(21): 5790-803, 2014 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25316499
12.
The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro.
BMC Med Genet
; 13: 13, 2012 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-22397687
13.
Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.
Addict Biol
; 17(2): 235-47, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21392179
14.
Sustained Trem2 stabilization accelerates microglia heterogeneity and Aß pathology in a mouse model of Alzheimer's disease.
Cell Rep
; 39(9): 110883, 2022 05 31.
Artigo
Inglês
| MEDLINE | ID: mdl-35649351
15.
AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome.
Neurobiol Dis
; 42(3): 311-7, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21316452
16.
AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trials.
Mov Disord
; 26(7): 1243-50, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21484867
17.
Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys.
J Neurochem
; 113(3): 715-24, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20132464
18.
mGluR5 antagonists: discovery, characterization and drug development.
Curr Opin Drug Discov Devel
; 11(5): 655-65, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18729017
19.
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.
Nat Rev Drug Discov
; 17(4): 280-299, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29217836
20.
Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methods.
J Nucl Med
; 48(7): 1207-15, 2007 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-17574984