Detalhe da pesquisa
1.
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
Nature
; 593(7859): 429-434, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34012082
2.
Publisher Correction: Programmable base editing of Aâ¢T to Gâ¢C in genomic DNA without DNA cleavage.
Nature
; 559(7714): E8, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29720650
3.
Programmable base editing of Aâ¢T to Gâ¢C in genomic DNA without DNA cleavage.
Nature
; 551(7681): 464-471, 2017 11 23.
Artigo
Inglês
| MEDLINE | ID: mdl-29160308
4.
CRISPR-derived genome editing therapies: Progress from bench to bedside.
Mol Ther
; 29(11): 3125-3139, 2021 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34619370
5.
ß-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
Nature
; 520(7547): 383-7, 2015 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25624104
6.
Epimerization and substrate gating by a TE domain in ß-lactam antibiotic biosynthesis.
Nat Chem Biol
; 10(4): 251-8, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24531841
7.
Celebrating Rosalind Franklin's Centennial with a Nobel Win for Doudna and Charpentier.
Mol Ther
; 28(12): 2519-2520, 2020 12 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33181064
8.
Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis.
J Org Chem
; 78(13): 6412-26, 2013 Jul 05.
Artigo
Inglês
| MEDLINE | ID: mdl-23758494
9.
Improved cytosine base editors generated from TadA variants.
Nat Biotechnol
; 41(5): 686-697, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36624149
10.
Engineering Cas9 for human genome editing.
Curr Opin Struct Biol
; 69: 86-98, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33964614
11.
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity.
Nat Commun
; 11(1): 2052, 2020 04 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32345976
12.
Directed evolution of adenine base editors with increased activity and therapeutic application.
Nat Biotechnol
; 38(7): 892-900, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32284586
13.
Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions.
Nat Commun
; 10(1): 3868, 2019 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31455765
14.
Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.
Nat Biotechnol
; 37(7): 820, 2019 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-31182863
15.
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.
Nat Biotechnol
; 37(6): 626-631, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31110355
16.
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.
Sci Adv
; 3(8): eaao4774, 2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28875174
17.
A Dimmer-Switch for SpCas9 Activity.
CRISPR J
; 2: 146-148, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31225755
18.
The Beginning of Base Editing: An Interview with Alexis C. Komor and Nicole M. Gaudelli.
CRISPR J
; 2: 81-90, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30998094