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1.
Indian Pediatr ; 48(12): 982-3, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22253161

RESUMO

This follow-up study conducted on children who underwent therapeutic cooling for hypoxic ischemic encephalopathy, showed normal neurodevelopmental outcome with normal milestones and normal developmental quotient in a minimum of 60% of children at 18-24 months of age. This study shows comparable neurodevelopmental outcome in infants who underwent cooling in a resource poor setting, when compared with existing literature.


Assuntos
Asfixia Neonatal/terapia , Hipotermia Induzida , Hipóxia-Isquemia Encefálica/terapia , Estudos de Coortes , Humanos , Índia , Lactente , Recém-Nascido , Resultado do Tratamento
2.
Indian Pediatr ; 48(6): 445-51, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21169643

RESUMO

OBJECTIVE: To determine the feasibility and safety of whole body cooling in newborn infants with perinatal asphyxial encephalopathy in a low resource setting. DESIGN: Feasibility trial. SETTING: Tertiary care perinatal centre. SUBJECTS: Infants born at > 35 weeks gestation with perinatal asphyxia were included in the study. INTERVENTIONS: Infants were cooled to a rectal temperature of 33 ± 0.5°C for 72 hours using cloth-covered ice-gel packs. Vital parameters were monitored continuously. OUTCOME MEASURES: The primary outcome was the achievement of target temperature within 1 hour of initiation of treatment and maintaining the target temperature for 72 hours. Adverse events and possible complications of hypothermia were the secondary outcomes measured. RESULTS: Twenty infants were included in the study. The mean time taken to achieve target rectal temperature was 52 ± 25 minutes. The mean rectal temperature during cooling was 32.9 ± 0.11ºC. The target temperature could be maintained for 72 hours without difficulty in all babies. Adverse events observed during cooling were thrombocytopenia (25%), sinus bradycardia (25%), deranged bleeding parameters (20%), aposteatonecrosis (15%), hyperglycemia (15%), hypoglycemia (10%), hypoxemia (5%), life-threatening coagulopathy (5%) and death (5%). Shivering was noted in many of the babies, especially in the initial phase of cooling. CONCLUSION: Whole body cooling in term infants with perinatal asphyxia is achievable, safe and inexpensive in a low-resource setting.


Assuntos
Asfixia Neonatal/terapia , Hipertermia Induzida/métodos , Hipóxia Encefálica/terapia , Terapia Intensiva Neonatal/métodos , Encéfalo/fisiologia , Países em Desenvolvimento , Estudos de Viabilidade , Feminino , Humanos , Hipertermia Induzida/economia , Índia , Recém-Nascido , Terapia Intensiva Neonatal/economia , Masculino
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