Detalhe da pesquisa
1.
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Bioorg Med Chem Lett
; 98: 129546, 2024 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37944866
2.
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Nat Chem Biol
; 12(7): 539-45, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27214403
3.
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew Chem Int Ed Engl
; 57(50): 16302-16307, 2018 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30288907
4.
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
J Biol Chem
; 289(26): 18302-13, 2014 Jun 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24798337
5.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
J Med Chem
; 67(11): 8609-8629, 2024 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38780468
6.
SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Cells
; 12(2)2023 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36672221
7.
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
J Med Chem
; 66(1): 460-472, 2023 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36562986
8.
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
J Biol Chem
; 286(48): 41616-41625, 2011 Dec 02.
Artigo
Inglês
| MEDLINE | ID: mdl-21914792
9.
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
J Biol Chem
; 285(49): 38204-13, 2010 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-20876572
10.
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc Natl Acad Sci U S A
; 105(17): 6457-62, 2008 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-18434541
11.
Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.
SLAS Discov
; 24(2): 133-141, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30359161
12.
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
J Med Chem
; 62(20): 9008-9025, 2019 10 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31550156
13.
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Cell Rep
; 26(1): 79-93.e8, 2019 01 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30605688
14.
Insights into the full-length SRPK2 structure and its hydrodynamic behavior.
Int J Biol Macromol
; 137: 205-214, 2019 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31229549
15.
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci
; 16(4): 683-94, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17384233
16.
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
J Med Chem
; 59(4): 1580-98, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26699912
17.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26741168
18.
Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: possible mode of action against insect pests.
Pest Manag Sci
; 58(11): 1101-6, 2002 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-12449528
19.
The roles of Jumonji-type oxygenases in human disease.
Epigenomics
; 6(1): 89-120, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24579949
20.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J Med Chem
; 55(14): 6639-43, 2012 Jul 26.
Artigo
Inglês
| MEDLINE | ID: mdl-22724510