Detalhe da pesquisa
1.
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Bioorg Med Chem Lett
; 28(12): 2159-2164, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29779975
2.
Essentiality of FASII pathway for Staphylococcus aureus.
Nature
; 463(7279): E3; discussion E4, 2010 Jan 21.
Artigo
Inglês
| MEDLINE | ID: mdl-20090698
3.
Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis.
Antimicrob Agents Chemother
; 56(3): 1444-51, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22155815
4.
Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria.
Antimicrob Agents Chemother
; 56(8): 4131-9, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22615276
5.
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 20(1): 294-8, 2010 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19906529
6.
Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay.
J Comput Aided Mol Des
; 23(12): 883-95, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19890608
7.
Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.
J Pharmacol Exp Ther
; 327(1): 1-9, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18599682
8.
Predicting oral clearance in humans: how close can we get with allometry?
Clin Pharmacokinet
; 47(1): 35-45, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18076217
9.
Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor.
Mol Cancer Ther
; 16(6): 1010-1020, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28341788
10.
Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4.
J Chromatogr A
; 1120(1-2): 94-101, 2006 Jul 07.
Artigo
Inglês
| MEDLINE | ID: mdl-16376901
11.
HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency.
Cardiovasc Res
; 67(3): 467-75, 2005 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15958262
12.
Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.
Expert Opin Drug Discov
; 11(1): 45-63, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-26484747
13.
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
ACS Med Chem Lett
; 6(1): 25-30, 2015 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25589925
14.
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
ACS Med Chem Lett
; 6(1): 31-6, 2015 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25589926
15.
Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes.
Biochem Pharmacol
; 67(3): 427-37, 2004 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15037195
16.
CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.
Biochem Pharmacol
; 64(11): 1579-89, 2002 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12429347
17.
Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.
Clin Pharmacokinet
; 50(8): 505-17, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21740074
18.
Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.
Clin Pharmacokinet
; 50(5): 307-18, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21456631
19.
JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity.
Clin Cancer Res
; 15(22): 6841-51, 2009 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19861438
20.
Discovery of potent, orally bioavailable small-molecule inhibitors of the human CCR2 receptor.
ChemMedChem
; 3(4): 660-9, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18188859