RESUMO
To delineate the effects of human chorionic gonadotropin (hCG) administration on immune responsiveness, immunological parameters including serum immunoglobulins, total and differential white blood cell count T and B lymphocyte membrane phenotype, in vitro, proliferative response to phytohaemagglutinin, Concanavalin A (ConA) and pokeweed mitogen were studied in 13 prepubertal cryptorchid boys before, during, and 3 months after hCG therapy. Before treatment, all the immunological parameters were normal except for an unexpected high percentage of T suppressor-cytotoxic cells (CD8+). During therapy, the absolute number of total peripheral blood lymphocytes, and that of total T-cells, T helper-inducer cells and of CD8+ subsets were diminished. The percentage of CD8+ cells and lymphocyte response to ConA decreased significantly and returned to normal after hCG withdrawal. The possible effects of long-term hCG treatment remain to be determined.
Assuntos
Gonadotropina Coriônica/efeitos adversos , Criptorquidismo/tratamento farmacológico , Criança , Concanavalina A/farmacologia , Criptorquidismo/imunologia , Humanos , Imunoglobulinas/análise , Ativação Linfocitária , Masculino , Fito-Hemaglutininas/farmacologia , Mitógenos de Phytolacca americana/farmacologia , Subpopulações de Linfócitos T , Linfócitos T Auxiliares-Indutores , Linfócitos T ReguladoresRESUMO
A 9.8-year-old girl with growth hormone (GH) deficiency and concomitant chronic and localized psoriasis of the groins and axillae showed repeated and sudden relapse of eruptive psoriasis after GH treatment. The aggravating effect of GH and the improvement of the skin condition after withdrawal suggests, at least in this case, that GH plays a significant role in the pathogenesis of psoriasis.