Detalhe da pesquisa
1.
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.
Bioorg Med Chem
; 71: 116951, 2022 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35973281
2.
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
Bioorg Med Chem Lett
; 27(11): 2617-2621, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28408219
3.
Enantioselective synthesis of cis-3-fluoropiperidin-4-ol, a building block for medicinal chemistry.
J Org Chem
; 78(17): 8892-7, 2013 Sep 06.
Artigo
Inglês
| MEDLINE | ID: mdl-23957501
4.
Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.
J Med Chem
; 66(24): 17086-17104, 2023 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38079537
5.
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways.
BMC Res Notes
; 7: 674, 2014 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-25252968
6.
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.
PLoS One
; 8(12): e81870, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-24339975
7.
Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication.
Antimicrob Agents Chemother
; 52(4): 1419-29, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18227176