Detalhe da pesquisa
1.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg Med Chem Lett
; 23(14): 4107-11, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23747226
2.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 7): 768-74, 2011 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21795790
3.
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Anal Biochem
; 392(1): 59-69, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19497292
4.
NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
J Med Chem
; 49(16): 5013-7, 2006 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16884313
5.
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
J Med Chem
; 49(24): 6946-9, 2006 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-17125246
6.
Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.
Protein Sci
; 14(6): 1472-84, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15929997
7.
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
J Med Chem
; 54(19): 6548-62, 2011 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21882820
8.
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.
J Med Chem
; 51(19): 6225-9, 2008 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-18771253
9.
X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir.
J Virol
; 81(17): 9525-35, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17537865