[Treatment of neutropenic enterocolitis]. / Behandling av nøytropen enterokolitt.

BACKGROUND: Neutropenic enterocolitis is a life-threatening complication that usually occurs in connection with chemotherapy for acute leukemias. Our experience with diagnosis and treatment of these patients is presented. MATERIAL AND METHODS: Medical records from patients treated for neutropenic enterocolitis at Ullevaal University Hospital in the period 2000-2008 were retrospectively reviewed. RESULTS: 16 patients with median age 33 years were treated for neutropenic enterocolitis. Induction chemotherapy was given for acute myelogenic (n = 9) or lymphatic (n = 4) leukemia, myelomatosis (n = 2) or lymphoma (n = 1). The patients developed aplasia five days (median) after start of chemotherapy. All patients were first treated conservatively with broad-spectrum antibiotics, fluids and electrolyte supplementation; nine of them recovered without complications. Four underwent surgery for perforation or ileus and these had the longest period with aplasia (median 31 days). Surgery for perforation is mainly limited resection and construction of ileostomy reservoirs (one or two). Three patients died. These were only treated conservatively; aplasia occurred quicker in these patients (after median two days) and they had the largest number of affected bowel segments (median nine). INTERPRETATION: Neutropenic enterocolitis is a heterogeneous condition and the treatment is mainly conservative. Surgical intervention is mandatory in patients with free intraabdominal air, ileus and intractable intestinal bleeding. The prognosis seems to worsen when aplasia develops after a short time and when there is a large number of affected bowel segments.

Pain and nausea after bariatric surgery with total intravenous anesthesia versus desflurane anesthesia: a double blind, randomized, controlled trial.

BACKGROUND: There is limited evidence-based knowledge regarding optimal anesthesia in obese patients. OBJECTIVE: To evaluate optimal anesthetic approach for patients undergoing bariatric surgery by determining and comparing peri- and postoperative outcomes in patients receiving intravenous anesthesia with propofol versus desflurane anesthesia. SETTING: Nonacademic primary referral center. METHODS: Patients who underwent laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass between 2016 and 2017 were randomized into 1 of the following 2 types of anesthesia: intravenous anesthesia with propofol, or desflurane. Perioperative outcomes were registered by the operation staff. A form based on visual analog scale estimating the patient's intensity of pain and nausea was completed postoperatively at the postoperative unit, surgical ward, and 24 to 48 hours postsurgery. The primary outcome was postoperative nausea and vomiting or postoperative pain between treatment groups. The secondary outcome was to evaluate the "time of awakening," peritoneal stretch, and use of perioperative muscle relaxants. RESULTS: One hundred eighty-three patients were randomized to receive intravenous anesthesia (n = 90) or desflurane anesthesia (n = 93). Mean time ± standard deviation of surgery for both procedures was 41 ± 17 minutes, whereas mean time of awakening was 2 ± 2 minutes for both the intravenous anesthesia and desflurane group. There was no significant difference in visual analog scale for pain or for nausea and vomiting postoperatively, nor in the number of patients receiving muscle relaxants for peritoneal stretch between the 2 groups. CONCLUSIONS: We found no significant differences between the 2 anesthetic regimens regarding postoperative nausea and pain, awakening time, peritoneal stretch, or the use of perioperative muscle relaxants.

Gastric sleeve resection as day-case surgery: what affects the discharge time?

BACKGROUND: Sleeve gastrectomy, with its short operating time, is possible to perform as same-day surgery, with the most common reason for requiring overnight hospital stay being postoperative nausea and vomiting. OBJECTIVE: To demonstrate the feasibility and safety of sleeve gastrectomy as same-day surgery with regard to complication rate. Additionally, the study aimed to evaluate factors determining the duration of hospital stay, such as type of anesthesia, time of procedure, degree of postoperative nausea and pain, American Society of Anesthesiologists score, or previous abdominal surgery. SETTING: Nonacademic primary referral center. METHODS: A substudy of a single-center, double-blind, randomized controlled trial. Patients included in this study underwent sleeve gastrectomy and were randomized into 1 of the following 2 types of anesthesia: total intravenous anesthesia with propofol or desflurane. Primary endpoint was the number of patients discharged the same day as surgery. Secondary endpoints were unplanned telephone calls, readmission rate, and complication rate. Time of procedure was registered by the staff at the operation theatre. Visual analog scales score estimating patients' intensity of pain and nausea were completed at the postoperative unit, surgical ward, and 24 to 48 hours postoperatively. RESULTS: Ninety-three patients were included in the study. Fifty-nine (63%) were discharged the same day as surgery (32 desflurane and 27 total intravenous anesthesia), 30 patients (32%) were discharged 1 day after surgery, and 4 patients (4%) were discharged after >2 days (15 desflurane and 19 total intravenous anesthesia). The most common reasons for prolonged stay were pain, nausea, and fatigue. Statistical analyses showed no association between day of discharge and the type of anesthesia, time of the procedure, degree of postoperative nausea and vomiting, pain intensity, American Society of Anesthesiologists score, or previous abdominal surgery. CONCLUSION: Same-day surgery is feasible and safe in terms of low complication rate. The type of anesthesia, time of procedure, degree of postoperative nausea and vomiting and pain, American Society of Anesthesiologists score and previous abdominal surgery does not appear to affect length of hospital stay.

[Treatment of oesophageal perforations]. / Behandling av oesophagusperforasjoner.

BACKGROUND: Esophageal perforation is a serious condition with a high mortality. Treatment is both surgical and conservative. MATERIAL AND METHODS: Records were retrospectively reviewed for 22 patients (17 men), with median age 64 (30-85) years, that had been treated for esophageal perforation at Ullevaal University Hospital in the period 2000-2006. RESULTS: Perforation was cervical in two (9%) patients, thoracic in 19 (86%) and abdominal in 1 (5%) of the patient(s). The etiology was iatrogenic in 11 (50%) patients, emetic in 8 (36%) and caused by a foreign body in 3 (14%) patients. Five patients with an iatrogenic etiology had oesophageal cancer. Diagnosis after onset of symptoms was evident within 24 hours in 41% patients, during 24-72 hours in 14% and later than 72 hours in 45% of the patients. Half of the patients (11) were treated surgically, including two that had been initially treated conservatively. Five patients (23%) died of thoracic perforations during hospitalization and there were no other deaths. Median hospital stay was 54 (3-174) days. At the end of follow-up median survival was 113 (12-660) days and 10 of the 22 patients were dead (45%). INTERPRETATION: Our impression is that early surgery of oesophageal perforation in fit patients can improve the outcome.