[Characteristics and evolution of COVID-19 in an urban Health Center at the pandemic beginning']. / Características y evolución de los pacientes COVID-19 en un centro de salud urbano al inicio de la pandemia.

OBJETIVE: To evaluate SAR-COV-2 pacients' features. To analyse de diferences between those who required hospital care and those who didn't. DESIGN: Observational, descriptive and retrospective study. SETTING: Twomedical practices of an urban health center in Salamanca (Spain). PARTICIPANTS: ≥18 years diagnosed with SAR-CoV-2 between March 11th and April 20th. MAIN MEASUREMENTS: clinical-epidemiological chatacteristics, diagnosis, treatment and outcome at the end of study RESULTS: 122 patients (63.9% female), 19.7% social and health care workers y 4.9% from nursing homes. Predominant age group: 46-60 years. 67.2% without comorbility. Predomint symptoms: low-grade fever (73.5%), cough (65.2%) y fever (43%). Average age of the patients requiring hospital care was higher: 59.85 (DE16.22) versus 50.78 (DE17.88) P=.013. 63.6% of all the patients monitored by Primary Health Care and 14.1% of patients that required assistance did not present dyspnea P=.001. Only 2.5% of the hospital-assisted patients, compared to 61.5% of Primary Health Care, were not tested P=.0001. 26 patients were attendedn at an emergency room: 11(9%) stayed and 2 (1.6%) passed away. No antibiotic or inhaler treatment for 52.5% and 70.5% respectively. The most used antipyretic treatment was paracetamol (78.7%). CONCLUSIONS: Prevalence in females, comorbility-free patients and in age range: 46-60 years. Complementary and confirmatory test were performed mainly in hospital care. Predominance of mild symptoms and favourable evolution. Highliting the role played by Primary Health Care in detection, early intervention and monitoring of severe cases.

Relationship between the FRAX index and physical and cognitive functioning in older people.

OBJECTIVE: To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS: Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS: A total of 375 patients were included (60% female) Patients with a low-risk FRAX for hip fractures had a higher Mini-mental (25, 95% CI = 24-27 vs. 22, 95% = 21 to 23, p = .0001), a higher Barthel index (88, 95% CI = 84-93 vs 72, 69 to 76, p = .0001) without differences in the Charlson index. Bivariate analysis showed an inverse association between FRAX and scales but logistic regression showed only female sex (OR 4.4, 95% CI = 2.6-7.6) and the non-dependent Barthel index (OR = 0.104, 95% CI = 0.014-0.792) remained significant and. Barthel index/Mini-mental constructed a significant model capable of predicting a risk of hip fracture of >3% measured by the FRAX index, with an area under the curve of 0.76 (95% CI = 0.7-0.81). CONCLUSIONS: The FRAX index is related to other markers of geriatric assessment and the association between these variables can predict a risk of hip fracture of >3% measured by the FRAX index. Key messages Geriatric assessment indexes may be as important as the FRAX index, which is based on clinical risk factors, in predicting the fracture risk in older patient.

Características y evolución de los pacientes COVID-19 en un centro de salud urbano al inicio de la pandemia / Characteristics and evolution of COVID-19 in an urban Health Center at the pandemic beginning

OBJETIVO: Evaluar las características de los pacientes con SARS-CoV-2 y analizar diferencias entre los que requirieron asistencia hospitalaria y los seguidos ambulatoriamente. DISEÑO: Estudio observacional, descriptivo, retrospectivo. EMPLAZAMIENTO: 2 unidades básicas asistenciales de un centro de salud urbano en Salamanca (España). PARTICIPANTES: Pacientes ≥ 18 años diagnosticados de SARS-CoV-2 entre el 11 de marzo y el 20 de abril. MEDICIONES PRINCIPALES: Características clínico-epidemiológicas, diagnóstico, tratamiento y desenlace a fecha fin de estudio. RESULTADOS: Ciento veintidós pacientes (63,9% mujeres), 19,7% trabajadores sociosanitarios y 4,9% institucionalizados. Franja etaria predominante: 46-60 años, edad media: 52,1(DE 17,85). El 67,2% sin comorbilidad. Síntomas más prevalentes: febrícula (73,5%), tos (65,2%) y fiebre (43%). La edad media de los que requieren atención hospitalaria es mayor a los seguidos ambulatoriamente: 59,85 años (DE 16,22) vs. 50,78 (DE 17,88); p = 0,013. El 63,6% del total seguidos por Atención Primaria no presentó disnea, frente a 17 (14,1%) de los que acudieron a Urgencias; p = 0,001. No se realizaron pruebas confirmatorias al 2,5% de los que visitaron el hospital, frente al 61,5% de los seguidos ambulatoriamente; p = 0,0001; 26 acuden a Urgencias: 11 (9%) ingresaron y 2 (1,6%) fallecieron. El 52,5% no necesitó antibioterapia y el 70.5% no requirió inhaladores. El antipirético más empleado fue paracetamol (78.7%). CONCLUSIONES: Prevalencia en mujeres, personas sin comorbilidad y en la franja de edad de 46-60 años. Las pruebas complementarias y confirmatorias se realizaron mayoritariamente en asistencia hospitalaria. Predominancia de sintomatología leve y evolución favorable. Destacamos el papel de Atención Primaria en la detección, la intervención temprana y el seguimiento en casos graves

OBJETIVE: To evaluate SAR-COV-2 pacients' features. To analyse de diferences between those who required hospital care and those who didn't. DESIGN: Observational, descriptive and retrospective study. SETTING: Two medical practices of an urban health center in Salamanca (Spain). PARTICIPANTS: ≥ 18 years diagnosed with SAR-CoV-2 between March 11 th and April 20 th. MAIN MEASUREMENTS: clinical-epidemiological chatacteristics, diagnosis, treatment and outcome at the end of study RESULTS: 122 patients (63.9% female), 19.7% social and health care workers y 4.9% from nursing homes. Predominant age group: 46-60 years. 67.2% without comorbility. Predomint symptoms: low-grade fever (73.5%), cough (65.2%) y fever (43%). Average age of the patients requiring hospital care was higher: 59.85 (DE16.22) versus 50.78 (DE17.88) P = .013. 63.6% of all the patients monitored by Primary Health Care and 14.1% of patients that required assistance did not present dyspnea P = .001. Only 2.5% of the hospital-assisted patients, compared to 61.5% of Primary Health Care, were not tested P = .0001. 26 patients were attendedn at an emergency room: 11(9%) stayed and 2 (1.6%) passed away. No antibiotic or inhaler treatment for 52.5% and 70.5% respectively. The most used antipyretic treatment was paracetamol (78.7%). CONCLUSIONS: Prevalence in females, comorbility-free patients and in age range: 46-60 years. Complementary and confirmatory test were performed mainly in hospital care. Predominance of mild symptoms and favourable evolution. Highliting the role played by Primary Health Care in detection, early intervention and monitoring of severe cases

Utilidad del índice de comorbilidad de Charlson en personas ancianas. Concordancia con otros índices de comorbilidad / Utility of the Charlson Comorbidity Index in older people and concordance with other comorbidity indices

Objetivo: El objetivo principal de nuestro estudio fue evaluar la utilidad actual del índice de comorbilidad de Charlson (CCI) para predecir la mortalidad en personas mayores y la concordancia entre varios índices. Diseño: Estudio observacional, cohorte concurrente. Emplazamiento: Servicio de Medicina Interna de un hospital terciario, pacientes ambulatorios de un centro de salud y residentes de cuatro hogares de ancianos. Participantes: 375 individuos ≥ 65 años, con supervivencia esperada ≥ 6 meses, sin deterioro cognitivo. Mediciones principales: Se realizaron tres índices: CCI, el índice geriátrico de comorbilidad (GIC) y el índice de Kaplan-Feinstein (KF). A los 12 meses, se registró mortalidad. Los datos se analizaron con IBM SPSS Statistics® versión 23.0. Resultados: Edad media: 81,4 años. El CCI mostró comorbilidad baja-media en el grupo ambulatorio de 65-75 años (43 [75,4%]); moderada-alta más común en hospitalizados (19 [61,3%]) y en hogares de ancianos (5 [62,5%]). Al año fallecieron 59 (16,1%) individuos: con CCI: 10 (6,4%) comorbilidad baja-media y 49 (23,3%) moderada-alta, odds ratio (OR) 3,63 (intervalo de confianza [IC] 95% 1,76-7,51); con KF: 27 (13,3%) baja-media y 32 (19,5%) moderada-alta, OR 1,38 (IC 95% 0,78-2,44), y con GIC: 45 (14,1%) baja-media y 14 (29,2%) moderada-alta, OR 2,47 (IC 95% 1,21-5,06). La concordancia entre CCI-KF fue: 65-75 años: K = 0,62, 76-85 años: K = 0,396, y ≥ 86 años: K = 0,255. La concordancia entre CCI-GIC: 65-75 años: K = 0,202, 76-85 años: K = 0,069, y ≥ 86 años: K = 0,118. Conclusión: El CCI es el mejor predictor de mortalidad después de 1 año de seguimiento. Concordancia considerable entre CCI y KF en los individuos de 65-75 años, en el resto de las franjas etarias la correlación con GIC fue insignificante.(AU)

Background: The main aim of our study was to evaluate the current usefulness of the CCI in predicting mortality in older people and the concordance between various comorbidity indices. Design: An observational, concurrent cohort study was performed. Location: Internal Medicine Service of a tertiary hospital, outpatients in a health centre and residents in four nursing homes. Participants: 375 individuals ≥65 years and with expected survival ≥6 months, without cognitive impairment. Main measurements: Three indices, the CCI, the Geriatric Index of comorbidity (GIC), and the Kaplan-Feinstein index (KFI), were administered in all participants. At 12 months, mortality was evaluated. The data were analyzed using the SPSS 23.0 statistical programme. Results: Average age 81.4 years. The CCI revealed low-medium comorbidity in the outpatient group aged 65-75: 43 (75.4%), moderate-high morbidity and more common in hospitalized patients: 19 (61.3%) and nursing homes: 5 (62.5%). At one year follow-up 59 (16.1%) individuals died: CCI: 10 (6.4%) low-medium and 49 (23.3%) moderate-high comorbidity, OR 3.63 (95% CI 1.76-7.51); KF: 27 (13.3%) low-medium and 32 (19.5%) moderate-high comorbidity, OR 1.38 (95% CI 0.78-2.44) and GIC: 45 (14.1%) low-medium and 14 (29.2%) moderate-high comorbidity, OR 2.47 (95% CI 1.21-5.06). The concordance between CCI-KF: 65-75 years K=0.62, 76-85 years: K=0.396 and ≥86 years: K=0.255. Concordance between CCI-GIC was: 65-75 years K=0.202, 76-85 years: K=0.069 and ≥86 years: K=0.118. Conclusion: CCI was found to be the best predictor of mortality after one year of follow up. There was considerable concordance between CCI and KF in the 65-75 years and remaining age groups. Correlation with GIC was low.(AU)

Afectación clínica y sintomatológica en pacientes mayores de 65 años por COVID-19 / Clinical involvement and symptoms of patients older than 65 years with COVID-19

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Crisis epiléptica complicada con un síndrome de takotsubo / Epileptic seizures complicated by Takotsubo syndrome

Introducción. El síndrome de takotsubo es un trastorno caracterizado por disfunción ventricular reversible, dolor precordial de tipo anginoso y cambios electrocardiográficos sin evidencia de obstrucción coronaria en coronariografía. Se desencadena por estrés, y es frecuente tras crisis epilépticas. Presentamos el caso de una paciente que inicia esta miocardiopatía tras una crisis epiléptica al finalizar su sesión de hemodiálisis. Caso clínico. Mujer de 55 años en hemodiálisis por insuficiencia renal crónica, con epilepsia secundaria a lesión residual frontoparietal derecha por un hematoma que precisó evacuación quirúrgica. Tras una sesión de hemodiálisis experimenta una crisis epiléptica focal con generalización secundaria y, horas después de ésta, dolor centrotorácico. En seriación enzimática se objetiva elevación de troponina I y, electrocardiográficamente, ondas T negativas en derivaciones precordiales (V2-V6). Se realiza coronariografía, cuyo resultado es normal, y se demuestran alteraciones de la contractilidad, confirmadas como de carácter transitorio en un estudio ecocardiográfico seriado. Todos los datos anteriores hacen sospechar el diagnóstico de síndrome de takotsubo. Conclusión. Las complicaciones cardíacas son una de las causas de morbimortalidad en la epilepsia, y entre ellas se encuentra el síndrome de takotsubo. La incidencia real de dicho síndrome se desconoce, pero dada su implicación en la mortalidad de causa cardíaca en la epilepsia es importante sospecharlo ante la presencia de disfunción cardíaca tras una crisis epiléptica (AU)

Introduction. Takotsubo syndrome is a disorder characterised by a reversible ventricular dysfunction, angina-like precordial pain and electromyographic changes with no evidence of coronary obstruction in examinations performed by coronary catheterisation. It is triggered by stress and is frequent following bouts of epileptic seizures. We report the case of a patient who began with this cardiomyopathy following epileptic seizures suffered after one of her aemodialysis sessions. Case report. We report the case of a 55-year-old female on haemodialysis due to chronic renal failure, with epilepsy secondary to a residual lesion in the right frontoparietal area due to a haematoma that required surgical evacuation. After her haemodialysis session she suffered an attack of focal epilepsy with secondary generalisation and, some hours later, pain in the middle of her chest. Serial enzymes revealed increased levels of troponin I and, electrocardiographically, negative T waves were observed in precordial derivations (V2-V6). Coronary catheterisation was performed, with normal results, and alterations were noted in contractility, which were confirmed as being transient in a serial echocardiography study. All the previous data lead us to a suspected diagnosis of Takotsubo syndrome. Conclusions. Cardiac complications are one of the causes of morbidity and mortality in epilepsy, and Takotsubo syndrome is an example of them. The real incidence of this syndrome is unknown, but given its involvement in mortality caused by heart problems in epilepsy it is important to suspect it in the presence of cardiac dysfunction following epileptic seizures (AU)