[Seroreactivity to hepatitis B virus surface antigen among different population groups in the City of Durango, Mexico]. / Serorreactividad al antígeno de superficie del virus de la hepatitis B en diversos grupos de población de la ciudad de Durango, México.

OBJECTIVE: To determine the seroprevalence of hepatitis B surface antigen (HBsAg) in several groups of populations in Durango City, Mexico. METHODS: An observational and comparative study was conducted in 6 groups of population in a total of 775 persons in Durango City, Mexico. The groups studied were 141 registered female sex workers, 100 medical students, 150 blood donors, 104 persons applying for medical certificates, 100 pregnant women, and 180 drug addicts. Serum samples of participants were analyzed for HBsAg by an immunoassay. HBsAg confirmation was performed by neutralization assay. RESULTS: Out of the 775 participants, 13 (1.7%) were positive by the immunoassay, and only 1 (0.1%) resulted positive by the confirmatory assay. This positive case was a drug addict and had a history of surgery and national and international trips. CONCLUSIONS: The seroprevalence of HBsAg in several groups of population in Durango City is low; the seroprevalence is comparable to or lower than those informed in other Mexican cities. It is strongly recommended to perform the HBsAg confirmation test due to low specificity of the immunoassay.

Serorreactividad al antígeno de superficie del virus de la hepatitis B en diversos grupos de población de la ciudad de Durango, México / Seroreactivity to hepatitis B virus surface antigen among different population groups in the City of Durango, Mexico", "_i": "en

Objetivo: Determinar la seroprevalencia del antígeno de superficie del virus de la hepatitis B (HBsAg) en diversos grupos de la población de la ciudad de Durango, México. Material y métodos: Estudio observacional y comparativo en seis grupos de población en un total de 775 personas adultas en la ciudad de Durango, México. Los grupos estudiados fueron 141 sexoservidoras registradas, 100 estudiantes de medicina, 150 donadores de sangre, 104 solicitantes de certificados médicos, 100 mujeres embarazadas, y 180 adictos a drogas. Se analizó el suero de los participantes para detectar el HBsAg mediante ensayo inmunoenzimático. La confirmación del HBsAg se realizó mediante prueba de neutralización. Resultados: De 775 personas, 13 (1.7%) fueron positivas al ensayo inmunoenzimático y solo una (0.1%) resultó positiva a la prueba confirmatoria. Este caso confirmado fue un adicto a drogas con antecedentes de cirugía y viajes nacionales y al extranjero. Conclusiones: La seroprevalencia de HBsAg en diversos grupos de la población de la ciudad de Durango, México, es baja, es comparable o más baja a las informadas en otras ciudades de México. Se recomienda realizar la prueba confirmatoria del HBsAg por la baja especificidad del ensayo inmunoenzimático.

OBJECTIVE: To determine the seroprevalence of hepatitis B surface antigen (HBsAg) in several groups of populations in Durango City, Mexico. METHODS: An observational and comparative study was conducted in 6 groups of population in a total of 775 persons in Durango City, Mexico. The groups studied were 141 registered female sex workers, 100 medical students, 150 blood donors, 104 persons applying for medical certificates, 100 pregnant women, and 180 drug addicts. Serum samples of participants were analyzed for HBsAg by an immunoassay. HBsAg confirmation was performed by neutralization assay. RESULTS: Out of the 775 participants, 13 (1.7%) were positive by the immunoassay, and only 1 (0.1%) resulted positive by the confirmatory assay. This positive case was a drug addict and had a history of surgery and national and international trips. CONCLUSIONS: The seroprevalence of HBsAg in several groups of population in Durango City is low; the seroprevalence is comparable to or lower than those informed in other Mexican cities. It is strongly recommended to perform the HBsAg confirmation test due to low specificity of the immunoassay.