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1.
J Allergy Clin Immunol ; 153(1): 103-110.e5, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37877904

RESUMO

BACKGROUND: Place-based social determinants of health are associated with pediatric asthma morbidity. However, there is little evidence on how social determinants of health correlate to the disproportionately high rates of asthma morbidity experienced by children <5 years old. OBJECTIVES: This study sought to evaluate census tract associations between the Child Opportunity Index ±COI) and at-risk rates (ARRs) for pediatric asthma-related emergency department (ED) encounters and hospitalizations in Washington, DC. METHODS: This was a cross-sectional study of children <5 years old with physician-diagnosed asthma included in the DC Asthma Registry between January 2018 and December 2019. Census tract COI score (1-100) and its 3 domains (social/economic, health/environmental, and educational) were the exposures (source: www.diversitydatakids.org). ED and hospitalization ARRs (outcomes) were created by dividing counts of ED encounters and hospitalizations by populations with asthma for each census tract and adjusted for population-level demographic (age, sex, insurance), clinical (asthma severity), and community (violent crime and limited English proficiency) covariates. RESULTS: Within a study population of 3806 children with a mean age of 2.4 ± 1.4 years, 2132 (56%) had 5852 ED encounters, and 821 (22%) had 1418 hospitalizations. Greater census tract overall COI, social/economic COI, and educational COI were associated with fewer ED ARRs. There were no associations between the health/environmental COI and ED ARRs or between the COI and hospitalization ARRs. CONCLUSION: Improving community-level social, economic, and educational opportunity within specific census tracts may reduce ED ARRs in this population.


Assuntos
Asma , Criança , Humanos , Lactente , Pré-Escolar , Estudos Transversais , District of Columbia/epidemiologia , Asma/epidemiologia , Hospitalização , Morbidade , Serviço Hospitalar de Emergência , Estudos Retrospectivos
2.
J Pediatr ; 273: 114120, 2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38815740

RESUMO

OBJECTIVE: To characterize patterns in the geospatial distribution of pre- and postnatally diagnosed congenital heart disease (CHD) across 6 surgical centers. STUDY DESIGN: A retrospective, multicenter case series from the Fetal Heart Society identified patients at 6 centers from 2012 through 2016 with prenatally (PrND) or postnatally (PoND) diagnosed hypoplastic left heart syndrome (HLHS) or d-transposition of the great arteries (TGA). Geospatial analysis for clustering was done by the average nearest neighbor (ANN) tool or optimized hot spot tool, depending on spatial unit and data type. Both point location and county case rate per 10 000 live births were assessed for geographic clustering or dispersion. RESULTS: Of the 453 CHD cases, 26% were PoND (n = 117), and 74% were PrND (n = 336). PrND cases, in all but one center, displayed significant geographic clustering by the ANN. Conversely, PoND cases tended toward geographic dispersion. Dispersion of PoND HLHS occurred in 2 centers (ANN = 1.59, P < .001; and 1.47, P = .016), and PoND TGA occurred in 2 centers (ANN = 1.22, P < .05; and ANN = 1.73, P < .001). Hot spot analysis of all CHD cases (TGA and HLHS combined) revealed clustering near areas of high population density and the tertiary surgical center. Hot spot analysis of county-level case rate, accounting for population density, found variable clustering patterns. CONCLUSION: Geographic dispersion among postnatally detected CHD highlights the need for a wider reach of prenatal cardiac diagnosis tailored to the specific needs of a community. Geospatial analysis can support centers in improving the equitable delivery of prenatal care.

3.
Am J Forensic Med Pathol ; 43(4): 328-333, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36103406

RESUMO

ABSTRACT: Sleep-related infant death is a major cause of infant mortality in the United States. In the District of Columbia, infant mortality varies widely among regions (2 to 14 per 1000 live births). The study objectives were to analyze the patient characteristics and related variables to sudden unexpected infant deaths at 2 pediatric emergency department (ED) sites and the geographic patterns of infant deaths and their relationship to social vulnerability. This retrospective cohort study examined infants under 1 year of age presenting with cardiac arrest at 2 ED sites from 2010 to 2020. Analysis showed 81 deaths with a median population age of 75 days (SD, 46 days). The most frequent demographics of deceased patients were African American Black (89%) with Medicaid insurance (63%), born at term gestation (66%), and without comorbidity (60%). The cause of death was most frequently undetermined (32%) and asphyxia (31%). Most cases involved bed-sharing (63%), despite more than half of those cases having a known safe sleep surface available. Infant death location showed that most deaths occurred in areas with the highest social vulnerability index, including near a community ED location. Understanding the etiologies of this geographic variability may enhance sleep-related infant death prevention strategies.


Assuntos
Morte Súbita do Lactente , Lactente , Criança , Humanos , Estados Unidos/epidemiologia , Morte Súbita do Lactente/epidemiologia , Morte Súbita do Lactente/etiologia , Estudos Retrospectivos , District of Columbia/epidemiologia , Asfixia , Sono , Causas de Morte
4.
J Pediatr Hematol Oncol ; 41(7): 559-560, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31094906

RESUMO

Hemarthrosis is a common musculoskeletal presentation in hemophilia. Intramuscular bleed is not uncommon. We report a young child who had a minor injury and calf swelling. He was initially diagnosed with deep vein thrombosis (DVT). Magnetic resonance imaging confirmed intramuscular hematoma and factor VIII assay confirmed hemophilia.


Assuntos
Hematoma/etiologia , Hemofilia A/complicações , Pré-Escolar , Erros de Diagnóstico , Hemofilia A/diagnóstico , Humanos , Perna (Membro) , Imageamento por Ressonância Magnética , Masculino , Ultrassonografia Doppler , Trombose Venosa/diagnóstico
5.
Pediatr Emerg Care ; 35(10): e188-e189, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28328694

RESUMO

OBJECTIVE: We describe a case of gastrointestinal duplication cyst with heterotopic gastric mucosa presenting with hematochezia. CASE: The patient was a previously healthy 2-month-old girl presenting with passing fresh blood in the diaper without distress or abdominal discomfort. She was evaluated for colic prior to this episode and discharged home. Meckel scan was positive, and surgeons performed an exploratory laparotomy to identify a jejunal duplication cyst. The infant had an uneventful recovery and was discharged home. CONCLUSIONS: Gastrointestinal duplication cyst is an uncommon condition and can rarely present with lower gastrointestinal bleed with heterotopic gastric mucosa.


Assuntos
Hemorragia Gastrointestinal/etiologia , Divertículo Ileal/diagnóstico por imagem , Divertículo Ileal/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Divertículo Ileal/patologia , Resultado do Tratamento , Ultrassonografia/métodos
6.
Pediatr Res ; 81(1-2): 265-270, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27723725

RESUMO

Robert Heinrich Herman Koch, a German physician and microbiologist, received Nobel Prize in 1905 for identifying the specific causative agent of tuberculosis (TB). During his time it was believed that TB was an inherited disease. However he was convinced that the disease was caused by a bacterium and was infectious, tested his postulates using guinea pigs, and found the causative agent to be slow growing mycobacterium tuberculosis. TB is the second most common cause of death from infectious diseases after HIV/AIDS. Drug-resistant TB poses serious challenge to effective management of TB worldwide. Multidrug-resistant TB accounted for about half a million new cases and over 200,000 deaths in 2013. Whole-genome sequencing (first done in 1998) technologies have provided new insight into the mechanism of drug resistance. For the first time in 50 y, new anti TB drugs have been developed. The World Health Organization (WHO) has recently revised their treatment guidelines based on 32 studies. In United States, latent TB affects between 10 and 15 million people, 10% of whom may develop active TB disease. QuantiFERON TB Gold and T-SPOT.TB test are used for diagnosis. Further research will look into the importance of newly discovered gene mutations in causing drug resistance.


Assuntos
Tuberculose/diagnóstico , Tuberculose/terapia , Adolescente , Animais , Criança , Pré-Escolar , Farmacorresistência Bacteriana , Genoma Viral , Saúde Global , Cobaias , História do Século XIX , História do Século XX , História do Século XXI , Migração Humana , Humanos , Lactente , Recém-Nascido , Tuberculose Latente , Mutação , Mycobacterium tuberculosis , Análise de Sequência de DNA , Tuberculose/epidemiologia , Tuberculose/história , Tuberculose Resistente a Múltiplos Medicamentos/diagnóstico , Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia , Tuberculose Resistente a Múltiplos Medicamentos/história , Tuberculose Resistente a Múltiplos Medicamentos/terapia , Estados Unidos , Adulto Jovem
7.
Clin Auton Res ; 25(5): 277-84, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26280217

RESUMO

PURPOSE: To investigate patterns of change in cerebral perfusion during head-up tilt testing (HUTT) in children and young adults with autonomic dysfunction. METHODS: We utilized near-infrared spectroscopy (NIRS) to estimate bilateral cerebral perfusion patterns during HUTT in 71 adolescents and young adults with a diagnosis of autonomic dysfunction. In addition, we used transthoracic impedance to measure cardiac stroke volume and thus infer autonomic tone, heart rate, and blood pressure during the test. Cerebral blood-flow wave-patterns were then visually analyzed and associated with clinical symptoms and measures of cardiovascular and autonomic function. RESULTS: Visual analysis of contour changes in head NIRS values during phases of HUTT revealed variable patterns of cerebral blood flow, some specifically associated with severe symptomatology (i.e., syncope). We also observed an inequality in blood flow of the cerebral hemispheres in many patients. Finally, we observed changes in cardiac stroke volume during HUTT, as previously reported, that related to changes in head NIRS. CONCLUSION: These results confirm a decrease in cerebral blood flow during HUTT as assessed by head NIRS in patients with autonomic dysfunction. Specifically, we have profiled the cerebral blood flow contours throughout the phases of HUTT, which add insight into the clinical spectrum of the disorder and may correlate with clinical severity.


Assuntos
Velocidade do Fluxo Sanguíneo/fisiologia , Circulação Cerebrovascular/fisiologia , Intolerância Ortostática/diagnóstico , Intolerância Ortostática/fisiopatologia , Teste da Mesa Inclinada/métodos , Adolescente , Feminino , Humanos , Masculino , Estudos Retrospectivos , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Adulto Jovem
8.
Pediatr Cardiol ; 36(1): 140-5, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25087055

RESUMO

Cardiac asystole during HUTT has been described by some investigators as a benign finding with no major sequelae. Our aim in this study is to correlate the severity of clinical symptoms and physiologic findings prior and during the asystole occurrence. This is a retrospective study review of 536 patients who underwent HUTT for dysautonomia symptoms for the last 3 years. HUTT in our institution consists of 10 min in supine, 30 min of head up at 70°, and recline to supine for 10 min. Physiologic parameters recorded include continuous heart rate, BP, cardiac stroke volume, brain blood flow by near-infra red spectroscopy, sympathetic and parasympathetic tones. Patients' complaints and signs during HUTT were recorded. Follow-up was conducted up to 34 months. Cardiac asystole was defined as the absence of ventricular activity for ≥3 s with cessation of BP signal for the same period on the monitor. Of the 536 patients studied, 25 patients developed cardiac asystole (4.7%). The asystolic group age was 15.1 + 3.8 years and weighed 56.7 + 21 kg. All the patients fainted and were not able to complete the test with average head up time of 13.8 + 7.1 min. The cardiac asystole duration was 9.2 + 5.8 s. Sixteen patients developed convulsions during the asystole. There was sudden intense vagal tone prior to and during the asystole. Brain perfusion was significantly decreased in all the patients after head up and sharply dropped by 20-35% in patients who developed convulsions. All patients completely recovered their consciousness after reposition to supine. During recovery, there was overshoot of the brain perfusion above the baseline for several minutes and the HR returned to baseline. Follow-up of these patients: only one patient had a single lead pacemaker, otherwise the 24 patients had no cardiac pacing and were treated by medical therapy. During mean follow-up of 19 + 10 months, five patients developed syncope which resolved after optimizing medical therapy. Cardiac asystole due to neurocardiogenic syncope and dysautonomia has high association with brain anoxia that can lead to convulsions. Such patients require intense medical therapy and close observation with possible intervention by cardiac pacing if prolonged asystole occurs. There is a concern of consequence future brain function.


Assuntos
Parada Cardíaca/fisiopatologia , Teste da Mesa Inclinada , Adolescente , Criança , Feminino , Parada Cardíaca/terapia , Humanos , Masculino , Posicionamento do Paciente , Estudos Retrospectivos , Adulto Jovem
9.
Hosp Pediatr ; 13(8): e218-e237, 2023 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-37455665

RESUMO

CONTEXT: Spatial analysis is a population health methodology that can determine geographic distributions of asthma outcomes and examine their relationship to place-based social determinants of health (SDOH). OBJECTIVES: To systematically review US-based studies analyzing associations between SDOH and asthma health care utilization by geographic entities. DATA SOURCES: Pubmed, Medline, Web of Science, Scopus, and Cumulative Index to Nursing and Allied Health Literature. STUDY SELECTION: Empirical, observational US-based studies were included if (1) outcomes included asthma-related emergency department visits or revisits, and hospitalizations or rehospitalizations; (2) exposures were ≥1 SDOH described by the Healthy People (HP) SDOH framework; (3) analysis occurred at the population-level using a geographic entity (eg, census-tract); (4) results were reported separately for children ≤18 years. DATA EXTRACTION: Two reviewers collected data on study information, demographics, geographic entities, SDOH exposures, and asthma outcomes. We used the HP SDOH framework's 5 domains to organize and synthesize study findings. RESULTS: The initial search identified 815 studies; 40 met inclusion criteria. Zip-code tabulation areas (n = 16) and census-tracts (n = 9) were frequently used geographic entities. Ten SDOH were evaluated across all HP domains. Most studies (n = 37) found significant associations between ≥1 SDOH and asthma health care utilization. Poverty and environmental conditions were the most often studied SDOH. Eight SDOH-poverty, higher education enrollment, health care access, primary care access, discrimination, environmental conditions, housing quality, and crime - had consistent significant associations with asthma health care utilization. CONCLUSIONS: Population-level SDOH are associated with asthma health care utilization when evaluated by geographic entities. Future work using similar methodology may improve this research's quality and utility.


Assuntos
Asma , Determinantes Sociais da Saúde , Criança , Humanos , Aceitação pelo Paciente de Cuidados de Saúde , Asma/epidemiologia , Asma/terapia , Pobreza , Acessibilidade aos Serviços de Saúde
10.
Pediatrics ; 150(2)2022 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-35871710

RESUMO

BACKGROUND AND OBJECTIVES: Compared with population-based rates, at-risk rates (ARRs) account for underlying variations of asthma prevalence. When applied with geospatial analysis, ARRs may facilitate more accurate evaluations of the contribution of place-based social determinants of health (SDOH) to pediatric asthma morbidity. Our objectives were to calculate ARRs for pediatric asthma-related emergency department (ED) encounters and hospitalizations by census-tract in Washington, the District of Columbia (DC) and evaluate their associations with SDOH. METHODS: This population-based, cross-sectional study identified children with asthma, 2 to 17 years old, living in DC, and included in the DC Pediatric Asthma Registry from January 2018 to December 2019. ED encounter and hospitalization ARRs (outcomes) were calculated for each DC census-tract. Five census-tract variables (exposures) were selected by using the Healthy People 2030 SDOH framework: educational attainment, vacant housing, violent crime, limited English proficiency, and families living in poverty. RESULTS: During the study period, 4321 children had 7515 ED encounters; 1182 children had 1588 hospitalizations. ARRs varied 10-fold across census-tracts for both ED encounters (64-728 per 1000 children with asthma) and hospitalizations (20-240 per 1000 children with asthma). In adjusted analyses, decreased educational attainment was significantly associated with ARRs for ED encounters (estimate 12.1, 95% confidence interval [CI] 8.4 to 15.8, P <.001) and hospitalizations (estimate 1.2, 95% CI 0.2 to 2.2, P = .016). Violent crime was significantly associated with ARRs for ED encounters (estimate 35.3, 95% CI 10.2 to 60.4, P = .006). CONCLUSION: Place-based interventions addressing SDOH may be an opportunity to reduce asthma morbidity among children with asthma.


Assuntos
Asma , Determinantes Sociais da Saúde , Adolescente , Asma/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Serviço Hospitalar de Emergência , Hospitalização , Humanos , Morbidade
11.
Artigo em Inglês | MEDLINE | ID: mdl-34625486

RESUMO

OBJECTIVE: The study's objective was to find the association between salmonellosis and socioeconomic status (SES) in hot spot areas and statewide counties. DESIGN: A retrospective cohort study. SETTING: The data were recorded regarding salmonellosis in 2017 from the Texas surveillance database. It included assessment of hot spot analysis and SES association with salmonellosis at the county level. PARTICIPANTS: Patients with salmonellosis of all age groups in Texas. RESULTS: There were a total of 5113 salmonellosis from 254 counties with an unadjusted crude rate of 18 per 100 000 person-years. Seven SES risk factors in the hot spot counties were as follows: low values of the severe housing problem, unemployment, African American and high values of social association rate, fast food/full-service restaurant use, Hispanic and Hispanic senior low access-to-store (p<0.05). A 12% difference existed between local health departments in hot (25%) and cold spot (37%) counties (χ2 (1, n=108)=0.5, p=0.81).Statewide independent risk factors were severe housing problem (incidence rate ratio (IRR)=1.1; 95% CI: 1.05 to 1.14), social association rate (IRR=0.89; 95% CI: 0.87 to 0.92), college education (IRR=1.05; 95% CI: 1.04 to 1.07) and non-Hispanic senior local access-to-store (IRR=1.98; 95% CI: 1.26 to 3.11). The severe housing problem predicted zero occurrences of infection in a county (OR=0.51; 95% CI: 0.28 to 0.95). CONCLUSIONS: Disparity exists in salmonellosis and SES. Attention to unmet needs will decrease salmonellosis. Severe housing problem is a notable risk.


Assuntos
Intoxicação Alimentar por Salmonella , Classe Social , Hispânico ou Latino , Humanos , Estudos Retrospectivos , Intoxicação Alimentar por Salmonella/epidemiologia , Texas/epidemiologia
12.
Expert Rev Anti Infect Ther ; 18(11): 1171-1175, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32580590

RESUMO

BACKGROUND: Hospital antibiotic use is rising. We aimed to evaluate the antibiotic-use prevalence and length of stay. METHODS: We conducted a single-center retrospective study of patients < 18-years-old admitted to general pediatric services who received ≥ 1 antibiotic over six months. Demographics, culture results and antibiotic details were collected. The primary outcome was to identify the total number and classes of antibiotics prescribed during the admission. Secondary outcomes included length of stay (LOS), culture results, and the most commonly used antibiotics. RESULTS: Forty-eight percent of patients received monotherapy (single class antibiotic). Cephalosporins (55%), vancomycin (35%), and clindamycin (22%) were prescribed more commonly than other antibiotic classes. Children were exposed up to 4 classes of antibiotics (range 1-4). A moderate correlation existed between the length of stay and the number of antibiotic classes used (R2 = 0.38). Two or more classes of antibiotic use prolonged the length of stay. Cephalosporin use was associated with 35% reduced LOS (95 CI, 21%-57%), and penicillin use correlated with 38% more prolonged LOS (95 CI, 22%-66%). CONCLUSIONS: Antibiotic use in pediatric hospitals was high, and children received multiple classes of antibiotics. Inappropriate antibiotic use and culture results may have an untoward effect on hospital length of stay.


Assuntos
Antibacterianos/uso terapêutico , Hospitalização/estatística & dados numéricos , Prescrição Inadequada/estatística & dados numéricos , Padrões de Prática Médica/estatística & dados numéricos , Adolescente , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Lactente , Recém-Nascido , Tempo de Internação/estatística & dados numéricos , Masculino , Prevalência , Estudos Retrospectivos , Estados Unidos
13.
J Hosp Med ; 15(2): 107-110, 2020 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-31532737

RESUMO

Inspired by the ABIM Foundation's Choosing Wisely® campaign, the "Things We Do for No Reason™" (TWDFNR) series reviews practices that have become common parts of hospital care but may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent "black and white" conclusions or clinical practice standards but are meant as a starting place for research and active discussions among hospitalists and patients. We invite you to be part of that discussion.


Assuntos
Ampicilina/uso terapêutico , Hemocultura , Infecções Comunitárias Adquiridas/tratamento farmacológico , Hospitalização , Pneumonia/diagnóstico , Pneumonia/tratamento farmacológico , Amoxicilina/uso terapêutico , Pré-Escolar , Tosse/etiologia , Dispneia/etiologia , Febre/etiologia , Humanos , Masculino , Streptococcus pneumoniae/isolamento & purificação , Vancomicina/uso terapêutico
14.
Pediatr Neonatol ; 61(1): 68-74, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31387844

RESUMO

BACKGROUND: Clinical presentation varies in children with Orthostatic Intolerance. This study aimed to evaluate the epidemiological and clinical characteristics of pediatric patients with orthostatic intolerance (OI) and positive head-up tilt test (HUTT). METHODS: This study was a retrospective review of clinical data from outpatients over 18 months period. RESULTS: We included 112 patients with abnormal HUTT results. Females were 78 (70%). Mean age of presentation was 15.6 years (sd: 3.3). Fifteen percent were overweight, and 14% were obese. A headache and syncope were the most frequent presenting symptoms (46% and 29% respectively). Review of systems identified more patients with headaches (84%), Syncope (61%), presyncope (87%) and abdominal pain (29%). Except for fatigue being more prevalent during a review of systems among patients with severe OI (69%) compared to those with moderate OI (46%, p = 0.02), there was no statistically significant difference in the clinical presentation between investigator-defined moderate and severe OI. Comorbidities identified in this cohort were Chiari malformations (9%), idiopathic intracranial hypertension (9%), electroencephalographic abnormalities (8%) and patent foramen ovale (43%). CONCLUSIONS: Adolescents, mainly females had OI. Patients with OI and abnormal HUTT predominantly had a headache, syncope, and presyncope during the presentation. Eliciting review of systems and using tools such as clinical questionnaire identifies significant clinical presenting features and comorbidities.


Assuntos
Intolerância Ortostática/epidemiologia , Teste da Mesa Inclinada , Adolescente , Criança , Demografia , Feminino , Cefaleia/epidemiologia , Humanos , Masculino , Estudos Retrospectivos
15.
Glob Pediatr Health ; 6: 2333794X19848674, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31106251

RESUMO

Introduction: Hyperhemolytic crisis is a rare and dangerous complication of sickle cell disease where the hemoglobin level drops rapidly. This can quickly lead to organ failure and death. In the literature, most cases of hyperhemolysis in sickle cell patients followed a red cell transfusion. Case Summary: In this article, we report a case of a 6-year-old African American boy with sickle cell disease who presented with fever, increased work of breathing, and consolidation in the left lower lobe of the lung on chest X-ray. He initially improved with oxygen, fluids, and antibiotics but his hemoglobin acutely dropped from 7.6 to 6 g/dL the next day of admission. He was not previously transfused, and his reticulocyte count remained high. Subsequent transfusion recovered his hemoglobin. Conclusion: This case demonstrates that in the background of the chronic hemolysis of sickle cell disease, an acute anemia should warrant exploration of aplastic crisis (parvovirus infection), immune hemolytic anemia, hepatic sequestration crisis, splenic sequestration crisis, and hyperhemolytic crisis as possible etiologies. Ongoing reticulocytosis and a source of infection may direct suspicion especially toward hyperhemolytic crisis even without preceding red cell transfusion. We propose that the optimum management should include full supportive care (including transfusions if necessary) and treatment of the underlying cause of hemolysis (such as infections or drug exposure).

17.
Pediatr Rheumatol Online J ; 17(1): 3, 2019 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-30630507

RESUMO

BACKGROUND: Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune disorders primarily affecting skeletal muscle. Pediatric coronary artery dilation is frequently discussed in Kawasaki disease. However, it has yet to be reported in the IIMs or antisynthetase syndrome. We report a unique case of a patient with IIM, antisynthetase syndrome and coronary artery dilation. CASE PRESENTATION: We report an adolescent presenting with joint symptoms, fever, and eye swelling with a clinical diagnosis of Juvenile Dermatomyositis. He subsequently developed diastolic hypotension with evidence of coronary artery dilation. He received steroids and immunoglobulin and followed by immunosuppressants with mild improvement in his symptoms. The adolescent later developed dyspnea and cough with CT lungs evident for cystic changes; lung biopsy showed interstitial fibrosis and inflammation, and muscle biopsy was abnormal as well. The anti-pl-12 antibody was positive. Following several weeks of treatment, an echocardiogram showed improvement in coronary artery dilation. His joint symptoms, muscle strength and respiratory symptoms have also improved. CONCLUSIONS: Coronary artery dilation is not well understood in IIMs or antisynthetase syndrome. Pathobiology of coronary artery involvement, its treatment and prognosis, and association with IIM and antisynthetase syndrome needs further exploration.


Assuntos
Doença da Artéria Coronariana/complicações , Vasos Coronários/patologia , Miosite/complicações , Adolescente , Autoanticorpos , Doença da Artéria Coronariana/terapia , Dilatação , Ecocardiografia , Glucocorticoides/uso terapêutico , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Imunossupressores/uso terapêutico , Pulmão/patologia , Masculino , Músculo Esquelético/patologia , Miosite/diagnóstico , Miosite/terapia , Tomografia Computadorizada por Raios X
18.
Glob Pediatr Health ; 6: 2333794X19897506, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31903415

RESUMO

Kommerell's diverticulum is a rare, congenital aortic arch anomaly, usually associated with other vascular abnormalities. When present with a concurrent right-sided aortic arch and an aberrant subclavian artery, this triad can form a vascular ring that encompasses the trachea and esophagus. This anatomical variant is usually asymptomatic but can present with respiratory symptoms due to compression of the trachea. In this report, we discuss a case of a Kommerell's diverticulum, which presented as frequent and recurring asthma exacerbations in a pediatric patient.

20.
BMJ Open ; 9(5): e025405, 2019 05 05.
Artigo em Inglês | MEDLINE | ID: mdl-31061025

RESUMO

INTRODUCTION: High-flow nasal cannula (HFNC) is a non-invasive form of respiratory support used increasingly in bronchiolitis. HFNC provides a variable amount of positive pressure similar to continuous positive airway pressure (CPAP). The positive pressure in CPAP can distend and loosen oesophageal sphincter pressure leading to increased reflux. It is unclear if HFNC causes a similar action. Feeding tubes are used to provide nutrition and hydration to patients that are unable to safely take oral feedings. If there is increased reflux from HFNC, this would increase the risk of aspiration. Our institution places nasoduodenal tubes (NDT) to eliminate this risk. The purpose of the study is to infer if there is a difference between NDT and nasogastric tube (NGT) feeding with regard to length of respiratory support, number of emesis, number of chest X-rays and readmission/emergency room revisit rates. METHODS AND ANALYSIS: Patients with bronchiolitis, on high-flow nasal cannula, and whose primary physicians have decided on feeding tube for nutrition/hydration will be approached for consent and enrolment. Patients will be randomised to NGT or NDT in variable block sizes and stratified into low- and high-risk groups. Outcomes will be analysed by both a frequentist and Bayesian statistical approach. ETHICS AND DISSEMINATION: The trial was approved by local institutional review board. Every attempt will be made to reduce to an absolute minimum the interval between completion of data collection and release of study results through appropriate dissemination mediums including abstracts, poster presentations and journal publications. TRIAL REGISTRATION NUMBER: NCT03346850; Pre-results.


Assuntos
Bronquiolite/terapia , Pressão Positiva Contínua nas Vias Aéreas , Nutrição Enteral , Intubação Gastrointestinal/métodos , Oxigenoterapia , Nutrição Enteral/instrumentação , Nutrição Enteral/métodos , Feminino , Humanos , Lactente , Recém-Nascido , Recém-Nascido Prematuro , Intubação Gastrointestinal/instrumentação , Masculino , Oxigenoterapia/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto
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