Detalhe da pesquisa
1.
Online Nucleotide Mapping of mRNAs.
Anal Chem
; 96(21): 8674-8681, 2024 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38712815
2.
Optimizing Messenger RNA Analysis Using Ultra-Wide Pore Size Exclusion Chromatography Columns.
Int J Mol Sci
; 25(11)2024 Jun 06.
Artigo
Inglês
| MEDLINE | ID: mdl-38892442
3.
Separation of Plasmid DNA Topological Forms, Messenger RNA, and Lipid Nanoparticle Aggregates Using an Ultrawide Pore Size Exclusion Chromatography Column.
Anal Chem
; 95(40): 15017-15024, 2023 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37747361
4.
Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing.
Mol Pharm
; 20(8): 4285-4296, 2023 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37462906
5.
Middle-out sequence confirmation of CRISPR/Cas9 single guide RNA (sgRNA) using DNA primers and ribonuclease T1 digestion.
Anal Bioanal Chem
; 415(14): 2809-2818, 2023 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-37093234
6.
Characterization of Impurities in Therapeutic RNAs at the Single Nucleotide Level.
Anal Chem
; 94(48): 16960-16966, 2022 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36410036
7.
On-line Sequencing of CRISPR Guide RNAs and Their Impurities via the Use of Immobilized Ribonuclease Cartridges Attached to a 2D/3D-LC-MS System.
Anal Chem
; 94(2): 1169-1177, 2022 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34932902
8.
Full Sequencing of CRISPR/Cas9 Single Guide RNA (sgRNA) via Parallel Ribonuclease Digestions and Hydrophilic Interaction Liquid Chromatography-High-Resolution Mass Spectrometry Analysis.
Anal Chem
; 93(44): 14792-14801, 2021 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34699173
9.
Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches.
Analyst
; 146(3): 747-769, 2021 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33410843
10.
Characterization of Antisense Oligonucleotide Impurities by Ion-Pairing Reversed-Phase and Anion Exchange Chromatography Coupled to Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry Using a Versatile Two-Dimensional Liquid Chromatography Setup.
Anal Chem
; 92(8): 5944-5951, 2020 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32191031
11.
Achiral-Chiral Two-Dimensional Liquid Chromatography Platform to Support Automated High-Throughput Experimentation in the Field of Drug Development.
Anal Chem
; 92(22): 15187-15193, 2020 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33142065
12.
Streamlined Characterization of an Antibody-Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry.
Anal Chem
; 91(23): 14896-14903, 2019 12 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31621311
13.
A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants.
Anal Chem
; 90(23): 13929-13937, 2018 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30371058
14.
An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates.
Anal Chem
; 90(3): 1578-1586, 2018 02 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29260862
15.
High-resolution separation of monoclonal antibodies mixtures and their charge variants by an alternative and generic CZE method.
Electrophoresis
; 39(16): 2083-2090, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29774560
16.
Characterizing the Effects of a "Switchable Water" Additive on the Aqueous Solubility of Small Molecules.
Chemphyschem
; 19(16): 2093-2100, 2018 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29451332
17.
Development of a LC-MS/MS method for the determination of isomeric glutamyl peptides in food ingredients.
J Sep Sci
; 41(4): 847-855, 2018 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-29193742
18.
Automated online deconjugation of antibody-drug conjugate for small molecule drug profiling.
J Chromatogr A
; 1715: 464575, 2024 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38150875
19.
Two-dimensional reversed phase-normal phase liquid chromatography for simultaneous achiral-chiral analysis to support high-throughput experimentation.
J Chromatogr A
; 1692: 463820, 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36796276
20.
Characterization of antisense oligonucleotide and guide ribonucleic acid diastereomers by hydrophilic interaction liquid chromatography coupled to mass spectrometry.
J Chromatogr A
; 1708: 464327, 2023 Oct 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37660562