1.
Nat Chem Biol
; 6(3): 238-243, 2010 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20139990
RESUMO
The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as nonselective. The synthesis and study of a focused library of cinnamic hydroxamates allowed the identification of, to our knowledge, the first nonselective HDAC inhibitor. These data will guide a more informed use of HDAC inhibitors as chemical probes and therapeutic agents.
2.
Angew Chem Int Ed Engl
; 47(8): 1469-72, 2008.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18188857