Detalhe da pesquisa
1.
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.
Proc Natl Acad Sci U S A
; 109(52): 21486-91, 2012 Dec 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23236186
2.
Thioamide-based fluorescent protease sensors.
J Am Chem Soc
; 136(5): 2086-93, 2014 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-24472041
3.
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
Proc Natl Acad Sci U S A
; 108(34): E526-34, 2011 Aug 23.
Artigo
Inglês
| MEDLINE | ID: mdl-21844374
4.
OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.
J Biol Chem
; 287(20): 16860-8, 2012 May 11.
Artigo
Inglês
| MEDLINE | ID: mdl-22433849
5.
The Trypanosoma cruzi protease cruzain mediates immune evasion.
PLoS Pathog
; 7(9): e1002139, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21909255
6.
The malaria parasite progressively dismantles the host erythrocyte cytoskeleton for efficient egress.
Mol Cell Proteomics
; 10(12): M111.010678, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21903871
7.
Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
J Am Chem Soc
; 134(42): 17704-13, 2012 Oct 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22998171
8.
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
Cancer Cell
; 5(5): 443-53, 2004 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15144952
9.
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Mol Pharmacol
; 78(2): 319-24, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20466822
10.
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Antimicrob Agents Chemother
; 54(9): 3597-604, 2010 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-20547797
11.
Is chemical genetics the new frontier for malaria biology?
Trends Pharmacol Sci
; 29(2): 51-6, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18199489
12.
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
J Med Chem
; 51(3): 545-52, 2008 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-18173229
13.
Development of bestatin-based activity-based probes for metallo-aminopeptidases.
Bioorg Med Chem Lett
; 18(22): 5932-6, 2008 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18823778
14.
Platelets, pyrexia, and plasmodia.
N Engl J Med
; 361(5): 526-8, 2009 Jul 30.
Artigo
Inglês
| MEDLINE | ID: mdl-19641212
15.
Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts.
Mol Biochem Parasitol
; 154(2): 148-57, 2007 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-17553576
16.
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.
Chem Biol
; 9(10): 1085-94, 2002 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-12401493
17.
Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.
PLoS One
; 10(6): e0128619, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26046535
18.
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.
Mol Biochem Parasitol
; 131(1): 65-75, 2003 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-12967713
19.
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
J Med Chem
; 47(12): 3212-9, 2004 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15163200
20.
A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites.
Cell Host Microbe
; 13(1): 15-28, 2013 Jan 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23332153