Detalhe da pesquisa
1.
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Pharmacol Rev
; 75(5): 885-958, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37164640
2.
Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[11C]YH132: Application in Drug Development and Neurodegenerative Diseases.
Chembiochem
; 25(7): e202300819, 2024 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38441502
3.
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.
J Am Chem Soc
; 145(28): 15094-15108, 2023 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37401816
4.
Mutually Rewarding Academia-Industry Collaborations in the Field of Chemical Biology.
Chembiochem
; 24(11): e202300121, 2023 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37140146
5.
EFMC: Trends in Medicinal Chemistry and Chemical Biology.
Chembiochem
; 24(7): e202200690, 2023 04 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36704975
6.
NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.
EMBO J
; 37(16)2018 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29875132
7.
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Nat Chem Biol
; 16(6): 667-675, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32393901
8.
Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System.
Chimia (Aarau)
; 76(5): 425-434, 2022 May 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38069714
9.
DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.
Bioconjug Chem
; 32(4): 702-712, 2021 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-33691062
10.
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes.
Chemistry
; 26(6): 1380-1387, 2020 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31961047
11.
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.
Molecules
; 24(18)2019 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31540271
12.
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.
J Am Chem Soc
; 140(19): 6067-6075, 2018 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29420021
13.
A Novel Selective Inverse Agonist of the CB2 Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies.
Mol Pharmacol
; 92(4): 389-400, 2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28747489
14.
From Structure-Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging.
Mol Pharm
; 14(11): 4064-4078, 2017 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28968497
15.
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning.
Nat Chem
; 16(2): 239-248, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37996732
16.
Prospective de novo drug design with deep interactome learning.
Nat Commun
; 15(1): 3408, 2024 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38649351
17.
Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.
Biomed Pharmacother
; 174: 116473, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38522237
18.
Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.
J Nucl Med
; 65(2): 300-305, 2024 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38164615
19.
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.
J Med Chem
; 67(3): 1758-1782, 2024 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38241614
20.
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists.
ACS Cent Sci
; 10(5): 956-968, 2024 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38799662