Detalhe da pesquisa
1.
Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).
Alzheimers Dement
; 19(6): 2287-2297, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36454709
2.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Prediction of Monoclonal Antibody Tumor Disposition.
Int J Mol Sci
; 23(2)2022 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35054865
3.
Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.
Mol Pharm
; 13(2): 586-98, 2016 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26674605
4.
Pharmacokinetics of paracetamol in Göttingen minipigs: in vivo studies and modeling to elucidate physiological determinants of absorption.
Pharm Res
; 31(10): 2696-707, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24792825
5.
The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.
Birth Defects Res B Dev Reprod Toxicol
; 98(2): 170-82, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23529913
6.
Learn-confirm in model-informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform.
CPT Pharmacometrics Syst Pharmacol
; 12(2): 139-143, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36418887
7.
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.
MAbs
; 15(1): 2261509, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37823690
8.
The dynamics of Aß distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.
J Pharmacokinet Pharmacodyn
; 39(3): 227-37, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22481485
9.
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Alzheimers Dement (N Y)
; 8(1): e12306, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35676943
10.
Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components.
J Pharmacokinet Pharmacodyn
; 38(5): 581-93, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21779940
11.
Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid.
Pharmaceutics
; 13(12)2021 Dec 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34959386
12.
Subcutaneous Site-of-Absorption Study with the Monoclonal Antibody Tocilizumab in Minipigs: Administration Behind Ear Translates Best to Humans.
AAPS J
; 22(3): 63, 2020 04 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32246215
13.
Gaining insights into the consequences of target-mediated drug disposition of monoclonal antibodies using quasi-steady-state approximations.
J Pharmacokinet Pharmacodyn
; 36(5): 407-20, 2009 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-19728050
14.
PKPD Assessment of the Anti-CD20 Antibody Obinutuzumab in Cynomolgus Monkey is Feasible Despite Marked Anti-Drug Antibody Response in This Species.
J Pharm Sci
; 108(11): 3729-3736, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31351865
15.
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.
Drug Metab Dispos
; 36(12): 2434-44, 2008 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18809732
16.
Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.
MAbs
; 10(5): 803-813, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29621428
17.
Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.
Clin Cancer Res
; 24(14): 3325-3333, 2018 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29463551
18.
Quantification of IgG monoclonal antibody clearance in tissues.
MAbs
; 9(6): 1007-1015, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28613103
19.
In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing.
Clin Cancer Res
; 22(17): 4417-27, 2016 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27117182
20.
Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.
Clin Pharmacol Ther
; 110(5): 1172-1175, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33991429