Detalhe da pesquisa
1.
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel.
Biol Chem
; 404(10): 909-930, 2023 09 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37555646
2.
Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.
Bioorg Med Chem
; 87: 117303, 2023 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37167713
3.
Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-ß) modulator.
Mol Divers
; 26(4): 2175-2188, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-34668104
4.
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Int J Mol Sci
; 23(16)2022 Aug 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36012668
5.
Development and characterisation of SMURF2-targeting modifiers.
J Enzyme Inhib Med Chem
; 36(1): 401-409, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-33430646
6.
Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives.
Int J Mol Sci
; 22(6)2021 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33803648
7.
A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice.
Molecules
; 26(15)2021 Jul 29.
Artigo
Inglês
| MEDLINE | ID: mdl-34361736
8.
A Lipophilic 4-Phenylbutyric Acid Derivative That Prevents Aggregation and Retention of Misfolded Proteins.
Chemistry
; 26(8): 1834-1845, 2020 Feb 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31773792
9.
Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases.
Bioorg Med Chem Lett
; 30(18): 127421, 2020 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32717613
10.
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch.
Int J Mol Sci
; 21(14)2020 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32664385
11.
Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site.
Int J Mol Sci
; 21(22)2020 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33218072
12.
Novel inhibitors of leukocyte transendothelial migration.
Bioorg Chem
; 92: 103250, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31580982
13.
Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage.
Skin Pharmacol Physiol
; 32(4): 173-181, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31079103
14.
Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.
J Biol Chem
; 291(48): 24986-25003, 2016 Nov 25.
Artigo
Inglês
| MEDLINE | ID: mdl-27738100
15.
Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.
Biochim Biophys Acta Biomembr
; 1859(10): 1900-1910, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28648676
16.
A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.
Pharm Res
; 34(12): 2873-2890, 2017 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-28983714
17.
Design and synthesis of novel protein kinase R (PKR) inhibitors.
Mol Divers
; 20(4): 805-819, 2016 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-27480630
18.
SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex.
J Biol Inorg Chem
; 20(8): 1287-98, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26547749
19.
Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice.
J Cell Mol Med
; 16(3): 594-604, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21564514
20.
Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin.
Eur J Med Chem
; 228: 113969, 2022 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34763945