Detalhe da pesquisa
1.
Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.
Cell
; 178(5): 1222-1230.e10, 2019 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31442409
2.
Structural insights into the inhibition of glycine reuptake.
Nature
; 591(7851): 677-681, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33658720
3.
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.
J Am Chem Soc
; 145(28): 15094-15108, 2023 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-37401816
4.
The Torsion Library: Semiautomated Improvement of Torsion Rules with SMARTScompare.
J Chem Inf Model
; 62(7): 1644-1653, 2022 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35318851
5.
Novel ß-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Angew Chem Int Ed Engl
; 60(10): 5436-5442, 2021 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33238058
6.
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells.
J Am Chem Soc
; 142(40): 16953-16964, 2020 10 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32902974
7.
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes.
Chemistry
; 26(6): 1380-1387, 2020 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31961047
8.
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.
Molecules
; 24(18)2019 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31540271
9.
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.
J Am Chem Soc
; 140(19): 6067-6075, 2018 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29420021
10.
Torsion Library Reloaded: A New Version of Expert-Derived SMARTS Rules for Assessing Conformations of Small Molecules.
J Chem Inf Model
; 56(1): 1-5, 2016 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26679290
11.
BACE1 inhibitors: a head group scan on a series of amides.
Bioorg Med Chem Lett
; 23(14): 4239-43, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23735744
12.
Tritium Labeling of Neuromedin S by Conjugation with [3H]N-Succinimidyl Propionate.
ACS Omega
; 8(2): 2367-2376, 2023 Jan 17.
Artigo
Inglês
| MEDLINE | ID: mdl-36687043
13.
Machine Learning and Computational Chemistry for the Endocannabinoid System.
Methods Mol Biol
; 2576: 477-493, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36152211
14.
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors.
Front Pharmacol
; 14: 1158091, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37637423
15.
TFD: Torsion Fingerprints as a new measure to compare small molecule conformations.
J Chem Inf Model
; 52(6): 1499-512, 2012 Jun 25.
Artigo
Inglês
| MEDLINE | ID: mdl-22670896
16.
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe.
Chem Sci
; 13(19): 5539-5545, 2022 May 18.
Artigo
Inglês
| MEDLINE | ID: mdl-35694350
17.
De novo design by pharmacophore-based searches in fragment spaces.
J Comput Aided Mol Des
; 25(10): 931-45, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21922280
18.
Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.
Bioorg Med Chem Lett
; 19(21): 6106-13, 2009 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19786348
19.
Safety screening in early drug discovery: An optimized assay panel.
J Pharmacol Toxicol Methods
; 99: 106609, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31284073
20.
Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors.
J Med Chem
; 62(24): 11165-11181, 2019 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31751140