Detalhe da pesquisa
1.
Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!
Chimia (Aarau)
; 68(7-8): 492-9, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25437389
2.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J Med Chem
; 2024 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38770784
3.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem
; 66(13): 9147-9160, 2023 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37395055
4.
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
J Med Chem
; 65(4): 3306-3331, 2022 02 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35133824
5.
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
J Med Chem
; 64(18): 13704-13718, 2021 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34491761
6.
Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations.
Org Lett
; 21(22): 9128-9132, 2019 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31696715
7.
Rapid synthesis of medium-ring fused polycarbocyclic systems by rearrangement of carbenoid-derived oxonium ylides.
Chem Commun (Camb)
; (40): 4134-6, 2007 Oct 28.
Artigo
Inglês
| MEDLINE | ID: mdl-17925953
8.
Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks.
Org Lett
; 14(1): 66-9, 2012 Jan 06.
Artigo
Inglês
| MEDLINE | ID: mdl-22111917
9.
Synthesis of novel angular spirocyclic azetidines.
Org Lett
; 13(4): 780-3, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21235246
10.
Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.
Org Lett
; 12(9): 1944-7, 2010 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-20356106
11.
An opened route to 1,3-dimethylenecyclobutanes via sequential ruthenium-catalyzed [2 + 2] cycloaddition of allenyl boronate and palladium Suzuki coupling.
J Am Chem Soc
; 127(33): 11582-3, 2005 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-16104717