Detalhe da pesquisa
1.
Rational design of a new antibiotic class for drug-resistant infections.
Nature
; 597(7878): 698-702, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34526714
2.
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Bioorg Med Chem
; 92: 117423, 2023 09 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37531921
3.
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
ACS Med Chem Lett
; 14(5): 566-576, 2023 May 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37197456
4.
Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.
Bioorg Med Chem Lett
; 21(22): 6800-3, 2011 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21982494
5.
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Bioorg Med Chem Lett
; 19(13): 3485-8, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19464884
6.
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
J Med Chem
; 50(19): 4728-45, 2007 Sep 20.
Artigo
Inglês
| MEDLINE | ID: mdl-17715908
7.
ETX2514 is a broad-spectrum ß-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Nat Microbiol
; 2: 17104, 2017 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-28665414
8.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
J Med Chem
; 57(11): 4584-97, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24828090
9.
In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.
ACS Chem Biol
; 7(11): 1866-72, 2012 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-22908966
10.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).
J Med Chem
; 55(22): 10010-21, 2012 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23043329