Association between Anaesthetic Technique and Oncological Outcomes after Colorectal Carcinoma Liver Metastasis Resection.

Background: Recently published studies suggest that the anaesthetic technique used during oncologic surgery can improve patient outcomes. Therefore, the authors evaluated the survival of patients with resected colorectal carcinoma liver metastases (CRCLMs) who received either EGA (general anaesthesia [GA] combined with epidural anaesthesia [EA]) or GA alone. Methods: We conducted an ambispective cohort study including 225 post-surgical CRCLM patients between May 2007 and July 2012 and performed a follow-up investigation of survival in July 2017. Results: The basic characteristics in the two groups were largely similar. The median (quartiles) recurrence interval for all patients was 10 (2.5, 23) months, and the median (quartiles) survival for CRCLM patients post-surgically was 37 (30.5, 51.5) months. Perioperative EA was associated with survival (P =0.039, log-rank test), with an estimated hazard ratio of 0.737 (95% CI 0.551-0.985) in the univariate analysis. Kaplan-Meier estimates of survival for GA and EGA suggested that GA might provide better outcomes than EGA [P=0.028, hazard ratio of 0.7328 (95% CI 0.5433-0.9884)]. Significant differences in anaesthesia techniques were found (P=0.048), with an adjusted estimated hazard ratio of 0.741 (95% CI 0.550-0.998) in the multivariate analysis. Subgroup analyses of patients in different age groups (< 40, ≥ 40 but <60, and ≥ 60 years old) suggested that no significant differences existed among all three subgroups. Conclusions: Compared with EGA, GA may provide a better survival outcome for CRCLM patients. The benefits of anaesthetic techniques in oncological surgery are most likely related to certain cancer types.

[Study of the effect of temperature on the conformation of ovotransferrin by two-dimensional infrared correlation spectroscopy].

The conformation changes of Apo-Ovotransferrin and Holo-Ovotransferrin were studied with the heat treatment 25-95 degrees C by using Fourier transform infrared spectroscopy (FTIR) and two-dimensional correlation spectroscopy analyzer. The results of one-dimensional infrared spectroscopy showed that with the increase in temperature, the peak at 3 300 cm(-1) of Apo-Ovo-transferrin shifted more than that of Holo-Ovotransferrin. The peak at 3 300 cm(-1) derived from stretching vibrations of N-H and O-H indicates that iron-binding enhanced the role of hydrogen bonds and resistance to heat. The changing order of the secondary structure of ovotransferrin was determined by analyzing two-dimensional infrared spectra,witch is beta-sheet>amide II >-CH2 - bending vibration. In addition, it was found that the cross-peaks at 1 652 and 1 688 cm(-1) are different in synchronous and asynchronous counter maps by comparing Apo-Ovotransferrin with Holo-Ovotransferrin. It was suggested that the temperature made less impact on the alpha-helix in Holo-Ovotransferrin than on that in Apo-Ovotransferrin, however, the beta-turn in Holo-Ovotransferrin was more sensitive to temperature.

[µ-3-(8-Quinol-yloxy)propanedi-yl]bis-[dicarbon-yl(η-methoxy-carbonyl-cyclo-penta-dien-yl)molybdenum(III)].

The crystal structure of the title dimolybdenum complex, [Mo(2)(C(12)H(9)NO)(C(7)H(7)O(2))(2)(CO)(4)], has a quasi-tetra-hedral Mo(2)C(2) cluster core attached to one 3-(8-quinol-yloxy)propanediyl (L) and two methoxy-carbonyl-cyclo-penta-dienyl (Cp') ligands which are coordinated to two Mo atoms: one Mo atom bonds two terminal CO ligands while the other links one terminal and one semi-bridging CO ligand. An intra-molecular C-H⋯N hydrogen bond results in the quinolyl plane of the L ligand approaching and being nearly perpendicular to one of the Cp' rings [88.09 (12)°]. In the supra-molecular structure, a one-dimensional comb-shaped infinite chain is formed approximately along the crystallographic c axis by a combination of inter-molecular C-H⋯O hydrogen bonds and locally generates a C(6) motif. Finally, pairs of inversion-related comb-shaped chains associate into a new ladder-shaped infinite chain through weak π-π stacking inter-actions between neighbouring quinolyl systems (pyridyl centroid-centroid distance = 3.853 Å).