RESUMO
OBJECTIVE: To investigate actions of protein and anthraquinone glucosides from Semen Cassia on learning and memory capacity and related substances of senile mice induced by D-galactose. METHOD: The subacute senile mouse models induced by injection of D-galactose subcutaneously were used. RESULT: Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice. Protein and anthraquinone glucosides from Semen Cassia not only inhibited the increase of malondialdehyde (MDA) in cerebrum of senile mice, but also enhanced the level of superoxide dismutase (SOD) in cerebrum and lessened the lipofuscin (LF) in liver tissue of senile mice. Protein from Semen Cassia could reduce the content of monoamine oxidase (MAO) in cerebrum of senile mice. CONCLUSION: Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice and delay aging.