RESUMO
Copper deficiency associated with neurological disorders is a well-documented condition. However, hypocupremia is less often recognized as a cause of cytopenias or bone marrow failure. We report an illustrative series of three new cases of bi-lineage cytopenia associated with copper deficiency. We have analyzed clinical features of current and historical cases to identify clues that could facilitate application of appropriate laboratory testing and heighten the level of clinical suspicion. By maintaining an appropriately high level of suspicion for potential copper deficiency and obtaining a serum copper level, bone marrow failure due to this condition can be correctly diagnosed and treated. We suggest that copper deficiency be included in the differential diagnosis of reversible causes of bone marrow failure syndromes including myelodysplastic syndrome.
Assuntos
Anemia/diagnóstico , Medula Óssea/anormalidades , Medula Óssea/patologia , Cobre/deficiência , Adulto , Anemia/complicações , Exame de Medula Óssea , Linhagem da Célula , Cobre/sangue , Cobre/metabolismo , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pancitopenia/diagnóstico , Pancitopenia/etiologia , Doenças do Sistema Nervoso Periférico/etiologiaRESUMO
The distribution of trihalomethanes in the water of the two main power stations and the 10 blending stations in Bahrain has been studied. Total trihalomethanes in the drinking water averaged 2.95 micrograms/l. Average concentrations (microgram/l) of individual compounds were: CHBr3, 2.17 +/- 0.3; CHBr2Cl, 0.48 +/- 0.14; CHBrCl2, 0.30 +/- 0.13.
Assuntos
Hidrocarbonetos Halogenados/análise , Poluentes Químicos da Água/análise , Barein , Cromatografia Gasosa , Geografia , Centrais ElétricasRESUMO
Floating-Harbor syndrome is a rare genetic disorder of unknown aetiology. It was described for the first time in 1973. The syndrome is characterized mainly by short stature, delay in speech development and characteristic facial features. This article describes a report of a case of the syndrome and emphasizes the oral aspects, including descriptions of soft tissues, teeth, occlusion, stage of dental development and findings on examination of the temporomandibular joint. The treatment provided and its outcome is also described. Hopefully this information will be compared with findings from other patients in the future to assist in clarifying the phenotype of the Floating-Harbor syndrome.