Pesquisa | Secretaria de Estado da Saúde

1.

An expanded universe of cancer targets.

Hahn, William C; Bader, Joel S; Braun, Theodore P; Califano, Andrea; Clemons, Paul A; Druker, Brian J; Ewald, Andrew J; Fu, Haian; Jagu, Subhashini; Kemp, Christopher J; Kim, William; Kuo, Calvin J; McManus, Michael; B Mills, Gordon; Mo, Xiulei; Sahni, Nidhi; Schreiber, Stuart L; Talamas, Jessica A; Tamayo, Pablo; Tyner, Jeffrey W; Wagner, Bridget K; Weiss, William A; Gerhard, Daniela S.

Cell ; 184(5): 1142-1155, 2021 03 04.

Artigo Inglês | MEDLINE | ID: mdl-33667368

2.

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.

Raghavan, Srivatsan; Winter, Peter S; Navia, Andrew W; Williams, Hannah L; DenAdel, Alan; Lowder, Kristen E; Galvez-Reyes, Jennyfer; Kalekar, Radha L; Mulugeta, Nolawit; Kapner, Kevin S; Raghavan, Manisha S; Borah, Ashir A; Liu, Nuo; Väyrynen, Sara A; Costa, Andressa Dias; Ng, Raymond W S; Wang, Junning; Hill, Emma K; Ragon, Dorisanne Y; Brais, Lauren K; Jaeger, Alex M; Spurr, Liam F; Li, Yvonne Y; Cherniack, Andrew D; Booker, Matthew A; Cohen, Elizabeth F; Tolstorukov, Michael Y; Wakiro, Isaac; Rotem, Asaf; Johnson, Bruce E; McFarland, James M; Sicinska, Ewa T; Jacks, Tyler E; Sullivan, Ryan J; Shapiro, Geoffrey I; Clancy, Thomas E; Perez, Kimberly; Rubinson, Douglas A; Ng, Kimmie; Cleary, James M; Crawford, Lorin; Manalis, Scott R; Nowak, Jonathan A; Wolpin, Brian M; Hahn, William C; Aguirre, Andrew J; Shalek, Alex K.

Cell ; 184(25): 6119-6137.e26, 2021 12 09.

Artigo Inglês | MEDLINE | ID: mdl-34890551

3.

A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer.

Takeda, David Y; Spisák, Sándor; Seo, Ji-Heui; Bell, Connor; O'Connor, Edward; Korthauer, Keegan; Ribli, Dezso; Csabai, István; Solymosi, Norbert; Szállási, Zoltán; Stillman, David R; Cejas, Paloma; Qiu, Xintao; Long, Henry W; Tisza, Viktória; Nuzzo, Pier Vitale; Rohanizadegan, Mersedeh; Pomerantz, Mark M; Hahn, William C; Freedman, Matthew L.

Cell ; 174(2): 422-432.e13, 2018 07 12.

Artigo Inglês | MEDLINE | ID: mdl-29909987

4.

Organoid Modeling of the Tumor Immune Microenvironment.

Neal, James T; Li, Xingnan; Zhu, Junjie; Giangarra, Valeria; Grzeskowiak, Caitlin L; Ju, Jihang; Liu, Iris H; Chiou, Shin-Heng; Salahudeen, Ameen A; Smith, Amber R; Deutsch, Brian C; Liao, Lillian; Zemek, Allison J; Zhao, Fan; Karlsson, Kasper; Schultz, Liora M; Metzner, Thomas J; Nadauld, Lincoln D; Tseng, Yuen-Yi; Alkhairy, Sahar; Oh, Coyin; Keskula, Paula; Mendoza-Villanueva, Daniel; De La Vega, Francisco M; Kunz, Pamela L; Liao, Joseph C; Leppert, John T; Sunwoo, John B; Sabatti, Chiara; Boehm, Jesse S; Hahn, William C; Zheng, Grace X Y; Davis, Mark M; Kuo, Calvin J.

Cell ; 175(7): 1972-1988.e16, 2018 12 13.

Artigo Inglês | MEDLINE | ID: mdl-30550791

5.

Defining a Cancer Dependency Map.

Tsherniak, Aviad; Vazquez, Francisca; Montgomery, Phil G; Weir, Barbara A; Kryukov, Gregory; Cowley, Glenn S; Gill, Stanley; Harrington, William F; Pantel, Sasha; Krill-Burger, John M; Meyers, Robin M; Ali, Levi; Goodale, Amy; Lee, Yenarae; Jiang, Guozhi; Hsiao, Jessica; Gerath, William F J; Howell, Sara; Merkel, Erin; Ghandi, Mahmoud; Garraway, Levi A; Root, David E; Golub, Todd R; Boehm, Jesse S; Hahn, William C.

Cell ; 170(3): 564-576.e16, 2017 Jul 27.

Artigo Inglês | MEDLINE | ID: mdl-28753430

6.

KRAS and YAP1 converge to regulate EMT and tumor survival.

Shao, Diane D; Xue, Wen; Krall, Elsa B; Bhutkar, Arjun; Piccioni, Federica; Wang, Xiaoxing; Schinzel, Anna C; Sood, Sabina; Rosenbluh, Joseph; Kim, Jong W; Zwang, Yaara; Roberts, Thomas M; Root, David E; Jacks, Tyler; Hahn, William C.

Cell ; 158(1): 171-84, 2014 Jul 03.

Artigo Inglês | MEDLINE | ID: mdl-24954536

7.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Galbraith, Matthew D; Allen, Mary A; Bensard, Claire L; Wang, Xiaoxing; Schwinn, Marie K; Qin, Bo; Long, Henry W; Daniels, Danette L; Hahn, William C; Dowell, Robin D; Espinosa, Joaquín M.

Cell ; 153(6): 1327-39, 2013 Jun 06.

Artigo Inglês | MEDLINE | ID: mdl-23746844

8.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.

Kwon, Jason J; Hajian, Behnoush; Bian, Yuemin; Young, Lucy C; Amor, Alvaro J; Fuller, James R; Fraley, Cara V; Sykes, Abbey M; So, Jonathan; Pan, Joshua; Baker, Laura; Lee, Sun Joo; Wheeler, Douglas B; Mayhew, David L; Persky, Nicole S; Yang, Xiaoping; Root, David E; Barsotti, Anthony M; Stamford, Andrew W; Perry, Charles K; Burgin, Alex; McCormick, Frank; Lemke, Christopher T; Hahn, William C; Aguirre, Andrew J.

Nature ; 609(7926): 408-415, 2022 09.

Artigo Inglês | MEDLINE | ID: mdl-35831509

9.

EGFR in limbo.

Eck, Michael J; Hahn, William C.

Cell ; 149(4): 735-7, 2012 May 11.

Artigo Inglês | MEDLINE | ID: mdl-22579278

10.

Cancer vulnerabilities unveiled by genomic loss.

Nijhawan, Deepak; Zack, Travis I; Ren, Yin; Strickland, Matthew R; Lamothe, Rebecca; Schumacher, Steven E; Tsherniak, Aviad; Besche, Henrike C; Rosenbluh, Joseph; Shehata, Shyemaa; Cowley, Glenn S; Weir, Barbara A; Goldberg, Alfred L; Mesirov, Jill P; Root, David E; Bhatia, Sangeeta N; Beroukhim, Rameen; Hahn, William C.

Cell ; 150(4): 842-54, 2012 Aug 17.

Artigo Inglês | MEDLINE | ID: mdl-22901813

11.

ß-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.

Rosenbluh, Joseph; Nijhawan, Deepak; Cox, Andrew G; Li, Xingnan; Neal, James T; Schafer, Eric J; Zack, Travis I; Wang, Xiaoxing; Tsherniak, Aviad; Schinzel, Anna C; Shao, Diane D; Schumacher, Steven E; Weir, Barbara A; Vazquez, Francisca; Cowley, Glenn S; Root, David E; Mesirov, Jill P; Beroukhim, Rameen; Kuo, Calvin J; Goessling, Wolfram; Hahn, William C.

Cell ; 151(7): 1457-73, 2012 Dec 21.

Artigo Inglês | MEDLINE | ID: mdl-23245941

12.

Biologically informed deep neural network for prostate cancer discovery.

Elmarakeby, Haitham A; Hwang, Justin; Arafeh, Rand; Crowdis, Jett; Gang, Sydney; Liu, David; AlDubayan, Saud H; Salari, Keyan; Kregel, Steven; Richter, Camden; Arnoff, Taylor E; Park, Jihye; Hahn, William C; Van Allen, Eliezer M.

Nature ; 598(7880): 348-352, 2021 10.

Artigo Inglês | MEDLINE | ID: mdl-34552244

13.

BET bromodomain inhibition as a therapeutic strategy to target c-Myc.

Delmore, Jake E; Issa, Ghayas C; Lemieux, Madeleine E; Rahl, Peter B; Shi, Junwei; Jacobs, Hannah M; Kastritis, Efstathios; Gilpatrick, Timothy; Paranal, Ronald M; Qi, Jun; Chesi, Marta; Schinzel, Anna C; McKeown, Michael R; Heffernan, Timothy P; Vakoc, Christopher R; Bergsagel, P Leif; Ghobrial, Irene M; Richardson, Paul G; Young, Richard A; Hahn, William C; Anderson, Kenneth C; Kung, Andrew L; Bradner, James E; Mitsiades, Constantine S.

Cell ; 146(6): 904-17, 2011 Sep 16.

Artigo Inglês | MEDLINE | ID: mdl-21889194

14.

Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis.

Sandoval, Gabriel J; Pulice, John L; Pakula, Hubert; Schenone, Monica; Takeda, David Y; Pop, Marius; Boulay, Gaylor; Williamson, Kaylyn E; McBride, Matthew J; Pan, Joshua; St Pierre, Roodolph; Hartman, Emily; Garraway, Levi A; Carr, Steven A; Rivera, Miguel N; Li, Zhe; Ronco, Lucienne; Hahn, William C; Kadoch, Cigall.

Mol Cell ; 71(4): 554-566.e7, 2018 08 16.

Artigo Inglês | MEDLINE | ID: mdl-30078722

15.

Discovery of antibodies and cognate surface targets for ovarian cancer by surface profiling.

Schröfelbauer, Bärbel; Kimes, Patrick K; Hauke, Paige; Reid, Charlotte E; Shao, Kevin; Hill, Sarah J; Irizarry, Rafael; Hahn, William C.

Proc Natl Acad Sci U S A ; 120(1): e2206751120, 2023 01 03.

Artigo Inglês | MEDLINE | ID: mdl-36574667

16.

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

Scholl, Claudia; Fröhling, Stefan; Dunn, Ian F; Schinzel, Anna C; Barbie, David A; Kim, So Young; Silver, Serena J; Tamayo, Pablo; Wadlow, Raymond C; Ramaswamy, Sridhar; Döhner, Konstanze; Bullinger, Lars; Sandy, Peter; Boehm, Jesse S; Root, David E; Jacks, Tyler; Hahn, William C; Gilliland, D Gary.

Cell ; 137(5): 821-34, 2009 May 29.

Artigo Inglês | MEDLINE | ID: mdl-19490892

17.

Unexpected pieces to the senescence puzzle.

Cichowski, Karen; Hahn, William C.

Cell ; 133(6): 958-61, 2008 Jun 13.

Artigo Inglês | MEDLINE | ID: mdl-18555773

18.

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan, Vasanthi S; Ryan, Matthew J; Dhruv, Harshil D; Gill, Shubhroz; Eichhoff, Ossia M; Seashore-Ludlow, Brinton; Kaffenberger, Samuel D; Eaton, John K; Shimada, Kenichi; Aguirre, Andrew J; Viswanathan, Srinivas R; Chattopadhyay, Shrikanta; Tamayo, Pablo; Yang, Wan Seok; Rees, Matthew G; Chen, Sixun; Boskovic, Zarko V; Javaid, Sarah; Huang, Cherrie; Wu, Xiaoyun; Tseng, Yuen-Yi; Roider, Elisabeth M; Gao, Dong; Cleary, James M; Wolpin, Brian M; Mesirov, Jill P; Haber, Daniel A; Engelman, Jeffrey A; Boehm, Jesse S; Kotz, Joanne D; Hon, Cindy S; Chen, Yu; Hahn, William C; Levesque, Mitchell P; Doench, John G; Berens, Michael E; Shamji, Alykhan F; Clemons, Paul A; Stockwell, Brent R; Schreiber, Stuart L.

Nature ; 547(7664): 453-457, 2017 07 27.

Artigo Inglês | MEDLINE | ID: mdl-28678785

19.

Discovery of a selective inhibitor of doublecortin like kinase 1.

Ferguson, Fleur M; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L; Kuljanin, Miljan; Kalekar, Radha L; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W S; Sulahian, Rita; Li, Lianbo; Poulin, Emily J; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R; Vasta, James D; Ohi, Ryoma; Sim, Taebo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M; Robers, Matthew B; Muthaswamy, Senthil; Lin, Charles Y; Look, A Thomas; Haigis, Kevin M; Mancias, Joseph D; Wolpin, Brian M; Aguirre, Andrew J; Hahn, William C; Westover, Kenneth D; Gray, Nathanael S.

Nat Chem Biol ; 16(6): 635-643, 2020 06.

Artigo Inglês | MEDLINE | ID: mdl-32251410

20.

Cancer research needs a better map.

Boehm, Jesse S; Garnett, Mathew J; Adams, David J; Francies, Hayley E; Golub, Todd R; Hahn, William C; Iorio, Francesco; McFarland, James M; Parts, Leopold; Vazquez, Francisca.

Nature ; 589(7843): 514-516, 2021 01.

Artigo Inglês | MEDLINE | ID: mdl-33500573

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