Detalhe da pesquisa
1.
First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy volunteers.
Clin Transl Sci
; 16(9): 1653-1666, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37350225
2.
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.
Proc Natl Acad Sci U S A
; 106(42): 17957-62, 2009 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-19805148
3.
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
Ann Clin Transl Neurol
; 9(1): 50-66, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35014217
4.
Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury.
J Neurosci
; 28(49): 13173-83, 2008 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-19052208
5.
Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness.
Learn Mem
; 15(8): 551-64, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18685145
6.
Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers.
Clin Drug Investig
; 39(9): 889-890, 2019 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-31338799
7.
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers.
Clin Drug Investig
; 39(9): 873-887, 2019 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-31172446
8.
Chronic Stimulation of Alpha-2A-Adrenoceptors With Guanfacine Protects Rodent Prefrontal Cortex Dendritic Spines and Cognition From the Effects of Chronic Stress.
Neurobiol Stress
; 2: 1-9, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25664335