Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 42
Filtrar
1.
Eur Spine J ; 24(6): 1282-8, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25155835

RESUMO

PURPOSE: Despite the high prevalence of low back pain during pregnancy there is still a lack in the understanding of its aetiology. Changes of the spinal posture due to the anatomical changes of the pregnant body seem to be in part responsible for the back pain. In this pilot study we assessed the potential to accurately measure the spinal posture and pelvic position during pregnancy without any harmful radiation using a spine and surface topography system. METHODS: Thirteen pregnant women were examined during the second and third trimester of their pregnancy, and postpartum. Twenty female, non-pregnant volunteers comprised the control group. The spinal posture and pelvic position were measured with a radiation-free spine and surface topography system. RESULTS: We found a significant increase in thoracic kyphosis during the course of pregnancy, but no increased lumbar lordosis. The lateral deviation of the spine also decreased significantly. However, we did not measure significant changes of the pelvic position during or after pregnancy. CONCLUSIONS: The results of our study show that pregnancy has an effect on the spinal posture, and that spine and surface topography can be used to measure these changes three-dimensionally and without any harmful radiation. In future studies this technique could allow to further evaluate the relationship between posture and low back pain during pregnancy, helping to understand the aetiology of low back pain in pregnancy as well as to identify methods for its prevention and treatment.


Assuntos
Pelve/anatomia & histologia , Postura/fisiologia , Gravidez/fisiologia , Coluna Vertebral/anatomia & histologia , Adulto , Antropometria/métodos , Feminino , Humanos , Cifose/patologia , Cifose/fisiopatologia , Dor Lombar/patologia , Dor Lombar/fisiopatologia , Projetos Piloto , Complicações na Gravidez/patologia , Complicações na Gravidez/fisiopatologia , Estudos Prospectivos , Adulto Jovem
2.
Eur Spine J ; 23(7): 1449-56, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24435982

RESUMO

PURPOSE: The purpose of this study was to investigate age differences in the response of the spine and pelvis to simulated leg length inequalities (LLIs). METHODS: A total of 107 subjects, separated into three age groups (group 1: 20-39 years, group 2: 40-59 years, group 3: >60 years), were used to evaluate for any age effects in the response to LLIs. LLIs of +10, +20, and +30 mm were simulated with a simulation platform on both sides, and the respective changes of pelvic position (pelvic obliquity, pelvic torsion) and spinal posture (lateral deviation, surface rotation, kyphotic, and lordotic angles) were measured with a rasterstereographic system. RESULTS: In all three age groups an increase in LLI led to significant changes in the pelvic position as measured by the parameters of pelvic obliquity and torsion. No significant differences in the response of the pelvis to the LLIs were found between the age groups. In all age groups an increase in surface rotation and lateral deviation of the spine with increasing LLIs was found. However, none of these parameters responded significantly different between the three age groups. CONCLUSIONS: Under static conditions, LLIs lead to significant changes of the pelvic position and spinal posture. Despite all known age-related changes, no significant differences of the measured pelvic and spinal parameters in elderly patients as a response to the simulated LLIs occurred.


Assuntos
Envelhecimento/fisiologia , Desigualdade de Membros Inferiores/fisiopatologia , Ossos Pélvicos/fisiologia , Coluna Vertebral/fisiologia , Adulto , Feminino , Humanos , Cifose/fisiopatologia , Lordose/fisiopatologia , Masculino , Pessoa de Meia-Idade , Fotogrametria , Projetos Piloto , Adulto Jovem
3.
Eur Spine J ; 22(6): 1354-61, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23479027

RESUMO

PURPOSE: Leg length inequalities (LLIs) can result in an increased energy consumption, abnormal gait or osteoarthritis of the hip. In a previous study we simulated different LLIs of up to 15 mm and evaluated their effects on the pelvic position and spinal posture. We found a correlation between LLIs and resulting changes of the pelvic position. Despite suggestions in the literature we were not able to detect significant changes of the spinal posture. Therefore, the purpose of this study was to determine the amount of LLI that would in fact alter the spinal posture. METHODS: The subjects were placed on a simulation platform, whose height could be precisely controlled by the measuring device, to simulate different LLIs of up to 20 mm. For LLIs >20 mm, additional precision-cut wooden blocks were used under one foot. After an adaptation period the resulting changes of the pelvis and spine were measured with a rasterstereographic device. RESULTS: We found a significant correlation between platform height changes and changes of the pelvic position. The frontal spinal parameters surface rotation and lateral deviation changed significantly when simulating differences greater than 20 mm. No changes of the sagittal spinal curvature were measured, however, a trend to decreasing kyphotic angles was noted. CONCLUSIONS: Our study has shown for the first time that LLIs >20 mm will lead to significant changes in the spinal posture of healthy test subjects. However, these changes were only found in frontal (surface rotation and lateral flexion) spinal parameters, but not in sagittal parameters. Here for the kyphotic angle only a tendency to decreasing angles was noted. We have also found a significant correlation between different leg lengths and changes of the pelvic position. Further, females and males seem to react in the same way to LLIs.


Assuntos
Desigualdade de Membros Inferiores/complicações , Postura/fisiologia , Coluna Vertebral/fisiologia , Adulto , Fenômenos Biomecânicos , Feminino , Humanos , Masculino , Pelve/fisiologia
4.
Knee Surg Sports Traumatol Arthrosc ; 21(2): 311-7, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22491707

RESUMO

PURPOSE: A bilateral fixed-angle plate was biomechanically compared to the two currently preferred methods of osteosynthesis for transverse patella fractures. It was hypothesized that the new angle-stable implant would provide a secure and sustainable fracture fixation, superior to the established standard techniques. METHODS: Twenty-one identical patellae made of polyurethane foam (Sawbones(®)), osteotomized to create a transverse two-part fracture, were fixed with modified anterior tension wiring, cannulated lag screws with anterior tension wiring or bilateral polyaxial 2.7-mm fixed-angle plates. The testing protocol consisted of 10,000 repetitive cycles using a non-destructive physiological load between 100 and 300 N at a simulated knee flexion of 60°. RESULTS: All 21 Sawbone(®)-patellae sustained repetitive loading up to 10,000 cycles without failing. The anterior tension wire group displayed significant displacement of the fracture gap (0.7 ± 0.2 mm) during cyclic loading, while both lag screws with tension wiring and bilateral fixed-angle plates showed no fracture gap widening at all (p < 0.01). CONCLUSION: The bilateral fixed-angle plate and cannulated lag screws with anterior tension wiring preserved a constantly reduced fracture gap over 10,000 tensile cycles in contrast to modified anterior tension wiring, which exhibited significant widening of the gap after initial loading. Results of in vitro testing indicate that bilateral fixed-angle plates provide sustainable fixation stability offering a promising new option in the treatment for transverse patella fractures.


Assuntos
Fixação Interna de Fraturas/instrumentação , Fraturas Ósseas/cirurgia , Patela/lesões , Patela/cirurgia , Fenômenos Biomecânicos , Placas Ósseas , Parafusos Ósseos , Fios Ortopédicos , Fraturas Ósseas/fisiopatologia , Humanos , Modelos Anatômicos , Patela/fisiopatologia
5.
J Pediatr Orthop ; 33(4): 409-14, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23653031

RESUMO

BACKGROUND: Arthroscopic suture fixation of tibial eminence fractures using FiberWire is a favorable therapeutic option. The application of biodegradable material may be of advantage especially during childhood. The aim of this study was to evaluate the biomechanical properties using the biodegradable suture materials PDS II and Vicryl compared with FiberWire. METHODS: Bone mineral density was evaluated by pqCT in 18 human knee specimens and 3 similar groups were formed. A standardized anterior tibial eminence fracture was created and suture fixation was performed using each suture material (PDS II, Vicryl, FiberWire) in 6 specimens. Cyclic testing and destructive loading to failure was conducted. RESULTS: Both testing modalities showed PDS II to be inferior to the other evaluated suture materials. Although significantly higher failure loads were seen with FiberWire sutures, Vicryl yielded comparable stiffness in load-to-failure testing. No significant differences between Vicryl and FiberWire could be observed under nondestructive cyclic conditions. CONCLUSIONS: Even though FiberWire yields a superior ultimate failure load, Vicryl presented comparable results under cyclic conditions. CLINICAL RELEVANCE: For tibial eminence fractures in children, Vicryl should be considered as an alternative biodegradable suture material. The use of PDS II cannot be advocated.


Assuntos
Implantes Absorvíveis , Densidade Óssea , Suturas , Fraturas da Tíbia/cirurgia , Artroscopia/métodos , Criança , Humanos , Osteotomia/métodos , Técnicas de Sutura , Tomografia Computadorizada por Raios X
6.
Skeletal Radiol ; 41(5): 531-7, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21701952

RESUMO

OBJECTIVE: To evaluate multidetector CT volumetry in the assessment of bone defect healing in comparison to histopathological findings in an animal model. MATERIALS AND METHODS: In 16 mini-pigs, a circumscribed tibial bone defect was created. Multidetector CT (MDCT) of the tibia was performed on a 64-row scanner 42 days after the operation. The extent of bone healing was estimated quantitatively by MDCT volumetry using a commercially available software programme (syngo Volume, Siemens, Germany).The volume of the entire defect (including all pixels from -100 to 3,000 HU), the nonconsolidated areas (-100 to 500 HU), and areas of osseous consolidation (500 to 3,000 HU) were assessed and the extent of consolidation was calculated. Histomorphometry served as the reference standard. RESULTS: The extent of osseous consolidation in MDCT volumetry ranged from 19 to 92% (mean 65.4 ± 18.5%). There was a significant correlation between histologically visible newly formed bone and the extent of osseous consolidation on MDCT volumetry (r = 0.82, P < 0.0001). A significant negative correlation was detected between osseous consolidation on MDCT and histological areas of persisting defect (r = -0.9, P < 0.0001). CONCLUSION: MDCT volumetry is a promising tool for noninvasive monitoring of bone healing, showing excellent correlation with histomorphometry.


Assuntos
Tomografia Computadorizada Multidetectores/métodos , Osteogênese/fisiologia , Tíbia/diagnóstico por imagem , Tíbia/fisiopatologia , Fraturas da Tíbia/diagnóstico por imagem , Fraturas da Tíbia/fisiopatologia , Cicatrização/fisiologia , Animais , Tomografia Computadorizada de Feixe Cônico/métodos , Feminino , Masculino , Suínos , Tíbia/patologia , Fraturas da Tíbia/patologia
7.
Knee Surg Sports Traumatol Arthrosc ; 20(10): 2092-7, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22203047

RESUMO

PURPOSE: Displaced tibial eminence fractures require surgical fixation in order to obtain a stable knee joint. Suture fixation with FiberWire(®) seems to be the most favorable therapeutic option. Biomechanical studies show failure of this technique most commonly due to a suture cutout with subsequent fracture of the tibial eminence fragment. The goal of this study is to compare the biomechanical properties of three different techniques of suture fixation using FiberWire(®). METHODS: Bone mineral density was evaluated in 18 human knee specimens by pqCT, and three similar groups were formed. A standardized anterior tibial eminence fracture was created, and suture fixation was performed using one of three different techniques in 6 specimens each. Cyclic and destructive testing was conducted. RESULTS: Significant differences between the three techniques could be shown neither in the cycles needed to achieve a steady state nor in a failure load or initial stiffness. Almost all specimens failed by suture cutout. CONCLUSION: The presented modification of the existing technique for suture fixation of tibial eminence fractures did not lead to an increased initial stability nor did it lower the rate of suture cutout. All tested suture techniques showed comparable initial stiffness and failure load.


Assuntos
Artroscopia/métodos , Fixação Interna de Fraturas/métodos , Traumatismos do Joelho/cirurgia , Técnicas de Sutura , Fraturas da Tíbia/cirurgia , Artroscopia/instrumentação , Fenômenos Biomecânicos , Fixação Interna de Fraturas/instrumentação , Humanos , Técnicas In Vitro , Técnicas de Sutura/instrumentação , Suturas , Suporte de Carga
8.
Int Orthop ; 36(3): 627-32, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21935622

RESUMO

PURPOSE: Treatment of acute subcutaneous Achilles tendon rupture remains challenging. Whereas the results of conservative and operative treatment are inconsistent, early mobilisation treatment seems to be beneficial. Besides suture repair, operative treatment using adhesives reveals promising results. Our hypothesis was that a gluing technique provides initial stability comparable to sutures. METHODS: In a biomechanical study, 18 fresh frozen sheep Achilles tendons were used to compare the biomechanical properties of suture repair using PDS® II and Bunnell's technique to tendon gluing using BioGlue® and Tissucol®. Load to failure testing was performed. RESULTS: Ultimate failure loads of sutures (146.2 ± 30.8 N) are significantly superior to the techniques using BioGlue® (38.4 ± 18.3 N; p <0.0001) or Tissucol® (4.7 ± 2.5 N; p <0.0001). Interestingly, no significant differences in stiffness were found between the application of BioGlue® and PDS® II. CONCLUSIONS: Suture repair provides significantly superior biomechanical properties compared to the use of both tested adhesives BioGlue® and Tissucol®. Based on the presented data we recommend the use of suture material for open Achilles tendon repair.


Assuntos
Tendão do Calcâneo/cirurgia , Materiais Biocompatíveis , Teste de Materiais , Traumatismos dos Tendões/cirurgia , Adesivos Teciduais , Tendão do Calcâneo/lesões , Animais , Fenômenos Biomecânicos , Análise de Falha de Equipamento , Ruptura , Ovinos , Âncoras de Sutura , Técnicas de Sutura
9.
Int Orthop ; 36(10): 2021-6, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22740187

RESUMO

PURPOSE: The aim of our study was to investigate trends over time in the mortality of elderly patients after femoral neck fractures treated with bipolar hemiarthroplasty. METHODS: Altogether 487 cases of femoral neck fracture treated with bipolar hemiarthroplasty were observed during a 20-year period. Mortality rates were calculated for five years postoperatively. To account for the age distribution of the study population standardised mortality ratios (SMR) with respect to the age-specific mortality of the German population were determined and compared. Additional changes of the SMRs over time and the influence of the time delay before surgery on long-term mortality were evaluated. RESULTS: Femoral neck fractures treated with bipolar hemiendoprosthesis have a significant impact on mortality. Postoperative mortality is increased in patients of all age groups, but the effect diminishes in higher age groups. The influence on mortality was significantly greater for men than for women. The SMR has decreased from 3.52 before 1995 to 1.2 after 2006. Since 2006 there is no longer an increase in mortality after surgical treatment of a femoral neck fracture compared to general German population of the same age. CONCLUSION: Femoral neck fractures treated with bipolar hemiendoprosthesis result in a significantly increased mortality, however in our population this impact has significantly decreased over time. The effect on mortality is less in women and higher age groups than in men and younger patients. No influence of the time between accident and surgery on mortality could be detected.


Assuntos
Fraturas do Colo Femoral/cirurgia , Hemiartroplastia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Idoso , Idoso de 80 Anos ou mais , Mau Alinhamento Ósseo/cirurgia , Feminino , Fraturas do Colo Femoral/mortalidade , Alemanha/epidemiologia , Hemiartroplastia/mortalidade , Hemiartroplastia/tendências , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Fatores Sexuais , Taxa de Sobrevida/tendências , Fatores de Tempo , Tempo para o Tratamento/estatística & dados numéricos
10.
Arch Orthop Trauma Surg ; 132(1): 57-63, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21877127

RESUMO

INTRODUCTION: A tibial nail with fixed-angle locking screws intends to combine the advantages of angular stability and intramedullary stabilization in extraarticular proximal tibial fractures. The goal of this study is to analyze if the angle stable tibial nail (ASN) is biomechanically more stable than an established conventional standard nail (CN). METHODS: Two types of nails were compared on a series of ten matched pairs of human tibiae. After setting a proximal tibial defect fracture, the intramedullary stabilized tibiae were axially loaded starting from 100 N increasing in steps of 100 N after every 200 cycles until failure was reached. Failure was defined as deformation of the fracture gap, fracturing of the bone or the implant. RESULTS: The two types of nails showed no significant difference in terms of maximum tolerated load, maximum cycles repeated or axial deformation of the bone-implant construct. The mean load at failure was 1,365 N for the CN and 1,195 N for the ASN. The mean axial deformation for conventional (19 mm) and angle stable nail (21 mm) did not differ significantly. Slightly less nail or screw loosening was noticed with the fixed-angle nail. CONCLUSION: No significant difference in stability between the two compared implants could be demonstrated. A trend could be shown indicating that the rate of nail loosening in the proximal osteotomized part of the bone was lower for the angle stable nail. This trend, however, could not be substantiated statistically.


Assuntos
Pinos Ortopédicos , Fixação Intramedular de Fraturas/instrumentação , Fraturas da Tíbia/cirurgia , Fenômenos Biomecânicos , Parafusos Ósseos , Humanos , Tíbia/lesões , Tíbia/fisiologia , Tíbia/cirurgia , Suporte de Carga
11.
Artigo em Inglês | MEDLINE | ID: mdl-35692287

RESUMO

Objective: For proximal humeral fractures open reduction und internal fixation (ORIF) with a fixed-angle plate is considered the gold standard for surgical management. However, it can lead to poor functional outcomes and is associated with postoperative complications. Therefore, the purpose of this study was to investigate the influence of fracture severity by applying a new classification (simple versus complex) on clinical outcome and quality of life after ORIF of proximal humerus fractures. Methods: We conducted a prospective clinical study with an average follow-up period of 12 (SD 1) months after ORIF of proximal humeral fractures with a fixed-angle plate. The postoperative function and quality of life was measured using the Oxford Shoulder Score (OSS) and the Constant Score. Data was tested for statistical significance with the Mann-Whitney test and Fisher's exact test. Based on the findings of this study a simplified fracture classification system has been developed. Results: Seventy-two patients with a mean age of 65 years (SD 12) with 69% being males were included. According to the Neer classification, 35% (n=25) non-displaced ("one-part fractures"), 19% (n=14) two-part fractures, 15% (n=11) three-part fractures and 31% (n=22) four-part fractures were detected. Regarding the AO/OTA classification, 18% (n=13) were type A fractures, 43% (n=31) type B and 39% (n=28) type C fractures. From these criteria we derived our own fracture classification, including 50% (n=36) simple and 50% (n=36) severe fractures. Patients with simple fracture types achieved significantly higher total values in the Constant Score as well as the OSS (p=0.008; p=0.013). The cumulative incidence of complications in the entire patient collective was 14% (n=10) with humeral head necrosis (n=5) occurring only in the severe fracture group. Conclusions: The postoperative clinical outcome as well as the incidence of humeral head necrosis after ORIF of proximal humeral fractures with a fixed-angle plate correlates with the fracture type and severity. The newly derived fracture classification into simple and severe fractures is suitable with regard to clinical results and complication rate. However, prospective studies comparing ORIF vs. conservative treatment of proximal humeral fractures of the same severity are required. Level of Evidence: III.

12.
J Trauma ; 70(4): 832-7, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21248651

RESUMO

BACKGROUND: A distal femur nail with fixed-angle locking screws intends to combine the advantages of angular stability and intramedullary stabilization in extraarticular distal femur fractures. The goal of this study was to analyze whether the locked compression distal femur nail (LCN) was biomechanically more stable than a conventional standard distal femur nail (CN). METHODS: Both nails were compared on a series of 10 matched pairs of human femora. After setting a distal femur defect fracture, the intramedullary stabilized femur was axially loaded starting from 100 N, increasing in steps of 100 N after every 200 cycles with a triangular frequency of 1 Hz, until a predefined point of failure was reached. RESULTS: The two types of nails showed no significant difference in terms of maximum tolerated load, maximum number of cycles repeated, or axial deformation of the bone-implant construct. The mean load at failure was 2,954 N for the CN and 2,483 N for the LCN. The mean axial deformation for the conventional (14.8 mm) and locked compression nail (15.3 mm) did not differ significantly. Mode of failure was a bony fracture in all specimens predominantly involving the proximal femur. CONCLUSIONS: No significant difference in stability between the two compared implants could be demonstrated. The LCN showed comparable characteristics under cyclic axial loading as the conventional distal femur nail. No migration into the articular space or implant failure was observed.


Assuntos
Pinos Ortopédicos , Fraturas do Fêmur/cirurgia , Fixação Intramedular de Fraturas/instrumentação , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Cadáver , Feminino , Fraturas do Fêmur/fisiopatologia , Humanos , Masculino , Teste de Materiais , Desenho de Prótese
13.
Handchir Mikrochir Plast Chir ; 53(3): 237-244, 2021 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-34134156

RESUMO

Bite injuries are common. Along with the resulting complications, they represent approximately 1-2 % of all emergency department visits. In over 75 %, the hands are affected. In Northern Europe, bites and subsequent infections are mainly caused by dogs and cats but also by humans.Up to 40 % of all hand infections are caused to bite injuries. Due to the multiple and complex compartments as well as the low soft tissue coverage of functionally relevant structures, even the smallest and most superficial bite injuries of the hand lead to infections. Any bite injury to the hand may subsequently may result in a fulminant infection and, rarely, even death.The spectrum of pathogens from the oral flora of the biting animal or person is diverse and includes aerobic and anaerobic bacterial strains. Bite injuries represent a major challenge for both the injured person and the attending physician. The rate of complications has been shown to increase with delayed medical consultation, lack of medical care and inadequate wound care. In this review, we discuss the types and complications of bite wounds, their potential risk of infection, their pathogen spectrum and appearance, and their effective treatment.


Assuntos
Mordeduras e Picadas , Mordeduras Humanas , Doenças do Gato , Doenças do Cão , Infecção dos Ferimentos , Animais , Gatos , Cães , Europa (Continente) , Humanos
14.
Handchir Mikrochir Plast Chir ; 53(3): 290-295, 2021 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-34134161

RESUMO

This review article addresses the epidemiology, ethology, clinic, diagnostics and therapy of infections of the wrist and small joints of the hand.


Assuntos
Artrite Infecciosa , Punho , Artrite Infecciosa/diagnóstico , Artrite Infecciosa/cirurgia , Mãos/cirurgia , Humanos , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/cirurgia
15.
Eur Spine J ; 19(10): 1735-9, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20490872

RESUMO

The Matthiass posture test is a clinical test to detect posture changes in children and adolescents. Aim of this study was to objectify this test using a dynamic rasterstereographic measuring device. We examined 31 healthy athletes during a modified Matthiass test with a dynamic rasterstereographic measuring system. Hereby the trunk inclination, kyphosis and lordosis angle were measured. The trunk inclination decreased by about 50% of the basic value just by raising the arms. Additional weight loads of only 5% body weight (bw) resulted in significant changes of the posture (lordosis and kyphosis angle) during this test. With this rasterstereographic measuring device it seems to be possible to determine spinal posture changes under dynamic conditions. The results suggest that additional weights of 5% bw during the Matthias-test are enough to create significant deviations in posture parameters, even in healthy subjects.


Assuntos
Antropometria/métodos , Avaliação da Deficiência , Cifose/diagnóstico , Lordose/diagnóstico , Fotogrametria/métodos , Postura/fisiologia , Adolescente , Antropometria/instrumentação , Fenômenos Biomecânicos/fisiologia , Feminino , Humanos , Cifose/patologia , Cifose/fisiopatologia , Lordose/patologia , Lordose/fisiopatologia , Masculino , Movimento/fisiologia , Fotogrametria/instrumentação , Exame Físico/métodos , Amplitude de Movimento Articular/fisiologia
16.
J Knee Surg ; 32(8): 820-824, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30193388

RESUMO

Total knee arthroplasty (TKA) is a very successful procedure. The alignment in TKA has been identified as being of importance to prevent early implant failure and patient dissatisfaction. Our hypothesis was that patients with a preoperative varus deformation remaining in a slight varus alignment as their natural alignment after TKA will have superior clinical results compared with patients who are restored in neutral alignment. A total of 115 patients were corrected from varus to neutral (varus-neutral) and in 33 patients a preoperative varus alignment was kept in varus (varus). Standardized preoperative and postoperative full-length hip-knee-ankle radiographs under full weight-bearing conditions were performed in all patients. The patients' knees were categorized preoperatively and postoperatively based on the angle between mechanical femoral axis and mechanical tibial axis. Knees with alignment between ± 3 degrees were categorized as neutrally aligned, whereas alignment within ≤ -3 degrees was categorized as varus. The Knee Injury Osteoarthritis Outcome Score (KOOS) and Oxford Knee Score were determined retrospectively. The varus group scored significantly better in total KOOS (p < 0.05) compared with the varus-neutral group. Also, a trend was visible in the Oxford Knee Score but this was not significant (p > 0.05). This trend was even more evident in varus knees which were slightly undercorrected. The results support the assumption that leaving a residual varus alignment after TKA leads to better functional outcomes in TKA for patients with preoperative varus osteoarthritis.


Assuntos
Artroplastia do Joelho/métodos , Coxa Vara , Idoso , Idoso de 80 Anos ou mais , Articulação do Tornozelo/diagnóstico por imagem , Feminino , Fêmur/cirurgia , Humanos , Joelho/cirurgia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Prótese do Joelho , Masculino , Osteoartrite do Joelho/cirurgia , Período Pós-Operatório , Radiografia , Recuperação de Função Fisiológica , Estudos Retrospectivos , Tíbia/cirurgia , Suporte de Carga
17.
Bone Res ; 7: 32, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31667001

RESUMO

Autologous bone marrow concentrate (BMC) and mesenchymal stem cells (MSCs) have beneficial effects on the healing of bone defects. To address the shortcomings associated with the use of primary MSCs, induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been proposed as an alternative. The aim of this study was to investigate the bone regeneration potential of human iMSCs combined with calcium phosphate granules (CPG) in critical-size defects in the proximal tibias of mini-pigs in the early phase of bone healing compared to that of a previously reported autograft treatment and treatment with a composite made of either a combination of autologous BMC and CPG or CPG alone. iMSCs were derived from iPSCs originating from human fetal foreskin fibroblasts (HFFs). They were able to differentiate into osteoblasts in vitro, express a plethora of bone morphogenic proteins (BMPs) and secrete paracrine signaling-associated cytokines such as PDGF-AA and osteopontin. Radiologically and histomorphometrically, HFF-iMSC + CPG transplantation resulted in significantly better osseous consolidation than the transplantation of CPG alone and produced no significantly different outcomes compared to the transplantation of autologous BMC + CPG after 6 weeks. The results of this translational study imply that iMSCs represent a valuable future treatment option for load-bearing bone defects in humans.

18.
Injury ; 47(8): 1737-43, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27354301

RESUMO

INTRODUCTION: Anterior tension wiring using Kirschner wires (K-wires) is still considered the standard treatment for patella fractures, despite its high complication rate. The objective of this prospective clinical study was to evaluate intra- and perioperative complications as well as the clinical outcome of patients with patella fracture treated with a new developed bilateral, polyaxial, fixed-angle 2.7mm patella plate. PATIENTS AND METHODS: Between 2011 and 2014 all patients with a patella fracture were included in this prospective study and treated with a fixed-angle patella plate. Avulsion fractures of the inferior or superior pole of the patella were excluded. All fractures were classified according to the AO/OTA fracture classification. During a twelve-month follow up period all intra- and postoperative complications were recorded as well as the time until fracture healing. One year postoperatively the Lysholm Score, the pre- and postoperative Tegner Score, the Hospital for Special Surgery Knee Score (HSS), the Turba Score, the Oxford Knee Score, the Knee injury and Osteoarthritis Outcome Score (KOOS), the Bostman Score and the Iowa Knee Score were surveyed. Altogether, 20 patella fractures in 19 patients were included in this prospective study. The most frequent type of fracture, n=10, was a simple transverse patella fracture (C1), followed by 7 comminuted patella fractures (C3) and 3 T-shaped patella fractures (C2). RESULTS: During the 12-month follow up period two patients treated with the patella plate had a complication. In one patient a superficial wound infection occurred, which was treated successfully with hardware removal and in one patient a fracture dislocation due to an implant failure occurred. X-rays demonstrated complete bony healing in all fractures on average 3.2 months postoperatively. All knee scores showed good to excellent clinical results one year postoperatively. CONCLUSION: The results of this first clinical study indicate that the fixed-angle patella plate is an effective and safe treatment option for patella fractures with a short operative learning curve. The treatment of communited patella fractures (C3) with a fixed-angle patella plate should be well-considered to avoid distending the indication and biomechanical properties.


Assuntos
Fixação Interna de Fraturas , Fraturas Ósseas/cirurgia , Fraturas Cominutivas/cirurgia , Articulação do Joelho/fisiopatologia , Patela/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Placas Ósseas , Fios Ortopédicos , Feminino , Fixação Interna de Fraturas/métodos , Consolidação da Fratura , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/fisiopatologia , Fraturas Cominutivas/diagnóstico por imagem , Fraturas Cominutivas/fisiopatologia , Humanos , Articulação do Joelho/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Patela/lesões , Patela/fisiopatologia , Estudos Prospectivos , Resultado do Tratamento
19.
Injury ; 47(12): 2718-2725, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27817884

RESUMO

Bone defects remain a challenge for patients and orthopaedic surgeons. Autologous transfer of cancellous bone grafts remains the standard of care. However, in recent years various osteoinductive substitute materials, such as platelet rich plasma (PRP) and hyperbaric oxygen therapy (HBO) have been shown to improve bone healing. This study evaluates the effects of a combined application of PRP and HBO with autologous bone grafting in an animal model. In 48 New Zealand White rabbits bone defects at the radius were filled with autologous bone harvested at the iliac crest. This was combined with application of autologous PRP and/or HBO treatment for the duration of this study. After 3 and 6 weeks histomorphometric, immunohistochemical and radiologic evaluations were performed. All animals tolerated the treatment well. Improved bone regeneration was shown in all groups at 6 weeks compared to 3 weeks. Additional application of PRP and HBO resulted in an increase in new bone formation and increased neovascularization at 3 and 6 weeks. There was no statistical significant difference between PRP and HBO application in these regards. A combinatory use of PRP and HBO resulted in an increased bone regeneration and neovascularization compared to all other groups. This study provides evidence for an improvement of bone regeneration with the combinatory application of PRP and HBO to autologous cancellous bone grafts in a model of weight bearing bone defects in rabbits. Also synergistic effects of these two measures on angiogenesis were evident.


Assuntos
Regeneração Óssea/fisiologia , Substitutos Ósseos/farmacologia , Diáfises/patologia , Consolidação da Fratura/fisiologia , Oxigenoterapia Hiperbárica/métodos , Ílio/transplante , Fraturas do Rádio/patologia , Transplante Autólogo , Animais , Diáfises/diagnóstico por imagem , Diáfises/lesões , Modelos Animais de Doenças , Plasma Rico em Plaquetas , Coelhos
20.
Artigo em Inglês | MEDLINE | ID: mdl-26734534

RESUMO

INTRODUCTION: Comminuted radial head fractures (Mason type III) continue to pose a challenge to orthopedic surgeons. When internal fixation is not possible, radial head arthroplasty has been advocated as the treatment of choice. The purpose of this retrospective study was to evaluate clinical and radiological short-term results of patients with Mason type III radial head fractures treated with a cemented bipolar radial prosthesis. METHODS: Twelve patients received cemented bipolar radial head hemiarthroplasty for comminuted radial head fractures. In all patients a CT scan was obtained prior to surgical treatment to assess all associated injuries. Postoperatively an early motion protocol was applied. All patients were evaluated clinically and radiologically at an average of 12.7 months. RESULTS: According to the Mayo Modified Wrist Score, the Mayo Elbow Performance Score, the functional rating index of Broberg and Morrey, and the DASH Score good to excellent results were obtained. Grip strength and range of motion were almost at the level of the unaffected contralateral side. Patient satisfaction was high, no instability or signs of loosening of the implant, and only mild signs of osteoarthritis were seen. CONCLUSION: Overall good to excellent short-term results for primary arthroplasty for comminuted radial head fractures were observed. These encouraging results warrant the conduction of further studies with long-term follow-up and more cases to see if these short-term results can be maintained over time.

SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa