1.
Angew Chem Int Ed Engl
; 53(14): 3650-3, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24554626
RESUMO
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein-protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display ß-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.