Detalhe da pesquisa
1.
A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia.
Invest New Drugs
; 40(4): 773-781, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35579731
2.
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
J Neurooncol
; 140(3): 519-527, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-30238350
3.
Ion Current-Based Proteomic Profiling for Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation.
J Proteome Res
; 15(9): 3147-57, 2016 09 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27480135
4.
Ligand binding cooperativity: Bioisosteric replacement of CO with SO2 among thrombin inhibitors.
Bioorg Med Chem Lett
; 26(16): 3850-4, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27445170
5.
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies.
Invest New Drugs
; 31(4): 967-73, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23361621
6.
KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.
Breast Cancer Res Treat
; 132(2): 391-409, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21509526
7.
Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro.
Dig Dis Sci
; 54(7): 1465-74, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18979199
8.
Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysin.
Angew Chem Int Ed Engl
; 52(6): 1822-8, 2013 Feb 04.
Artigo
Inglês
| MEDLINE | ID: mdl-23283700
9.
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
J Med Chem
; 61(11): 4704-4719, 2018 06 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29617135
10.
Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation.
Eur J Med Chem
; 125: 975-991, 2017 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27816890
11.
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression.
Mol Cancer Res
; 15(11): 1491-1502, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28751463
12.
Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.
Cancer Res Treat
; 49(3): 643-655, 2017 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-27737538
13.
Prevention of noise-induced hearing loss with Src-PTK inhibitors.
Hear Res
; 208(1-2): 14-25, 2005 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-15950415
14.
Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors.
Eur J Med Chem
; 96: 405-24, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25912673
15.
Additivity or cooperativity: which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?
Eur J Med Chem
; 90: 897-915, 2015 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25559080
16.
Influence of neighboring groups on the thermodynamics of hydrophobic binding: an added complex facet to the hydrophobic effect.
J Med Chem
; 57(6): 2315-33, 2014 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24479949
17.
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
Cancer Chemother Pharmacol
; 71(4): 883-92, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23314737
18.
Targeting SRC and tubulin in mucinous ovarian carcinoma.
Clin Cancer Res
; 19(23): 6532-43, 2013 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24100628
19.
Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons.
Angew Chem Int Ed Engl
; 46(44): 8511-4, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17902081
20.
Water mediated ligand functional group cooperativity: the contribution of a methyl group to binding affinity is enhanced by a COO(-) group through changes in the structure and thermodynamics of the hydration waters of ligand-thermolysin complexes.
J Med Chem
; 55(19): 8283-302, 2012 Oct 11.
Artigo
Inglês
| MEDLINE | ID: mdl-22894131