Detalhe da pesquisa
1.
Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: A post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials.
Diabetes Obes Metab
; 24(5): 868-880, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34981622
2.
Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial.
JAMA
; 322(18): 1780-1788, 2019 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31714986
3.
Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus.
Arterioscler Thromb Vasc Biol
; 34(3): 676-83, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24385236
4.
Measuring vs Estimating LDL-C Levels in a Clinical Trial of Bempedoic Acid-Reply.
JAMA
; 323(11): 1095-1096, 2020 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32181844
5.
ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK.
J Lipid Res
; 54(8): 2095-2108, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23709692
6.
AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.
J Lipid Res
; 54(1): 134-51, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23118444
7.
Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase.
Clin Pharmacol Drug Dev
; 12(10): 1022-1035, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37477389
8.
Evaluation of the efficacy and safety of bempedoic acid in women and men: Pooled analyses from phase 3 trials.
Atherosclerosis
; 384: 117192, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37648637
9.
AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases.
J Lipid Res
; 53(12): 2490-514, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22798688
10.
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Bioorg Med Chem Lett
; 21(9): 2725-31, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21183342
11.
Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: A randomized clinical trial.
Atherosclerosis
; 320: 122-128, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33514449
12.
Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins.
Am J Prev Cardiol
; 8: 100278, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34746903
13.
Complementary low-density lipoprotein-cholesterol lowering and pharmacokinetics of adding bempedoic acid (ETC-1002) to high-dose atorvastatin background therapy in hypercholesterolemic patients: A randomized placebo-controlled trial.
J Clin Lipidol
; 13(4): 568-579, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31202641
14.
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
J Med Chem
; 51(1): 31-45, 2008 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-18072721
15.
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Bioorg Med Chem Lett
; 18(3): 1151-6, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18155906
16.
Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.
Atherosclerosis
; 277: 195-203, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29910030
17.
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.
Atherosclerosis
; 189(2): 264-72, 2006 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16458317
18.
Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy.
Am J Cardiol
; 117(12): 1928-33, 2016 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27138185
19.
Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.
J Clin Lipidol
; 10(3): 556-67, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27206943
20.
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
Circulation
; 110(22): 3465-71, 2004 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-15545514