Detalhe da pesquisa
1.
Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.
Immunol Rev
; 270(1): 132-51, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26864109
2.
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering.
J Immunol
; 195(7): 3198-205, 2015 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26320252
3.
Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.
Xenobiotica
; 47(3): 194-201, 2017 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-27151820
4.
Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.
Blood
; 124(20): 3165-71, 2014 Nov 13.
Artigo
Inglês
| MEDLINE | ID: mdl-25274508
5.
Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.
Xenobiotica
; 44(12): 1127-34, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25030041
6.
Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations.
BioDrugs
; 37(1): 99-108, 2023 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-36449140
7.
Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A.
MAbs
; 15(1): 2222441, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37339067
8.
Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation.
Pharmaceuticals (Basel)
; 15(5)2022 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35631335
9.
In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody.
Sci Rep
; 12(1): 4907, 2022 03 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35318394
10.
Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering.
MAbs
; 14(1): 2068213, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35482905
11.
Simple Approach to Accurately Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies after Subcutaneous Injection in Humans.
Clin Pharmacokinet
; 60(1): 111-120, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32779124
12.
Estimation of Clearance and Bioavailability of Therapeutic Monoclonal Antibodies from Only Subcutaneous Injection Data in Humans Based on Comprehensive Analysis of Clinical Data.
Clin Pharmacokinet
; 60(10): 1325-1334, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33954956
13.
A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target.
AAPS J
; 23(1): 21, 2021 01 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33415498
14.
Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.
Br J Pharmacol
; 178(21): 4335-4351, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34232502
15.
Novel myostatin-specific antibody enhances muscle strength in muscle disease models.
Sci Rep
; 11(1): 2160, 2021 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33495503
16.
Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment.
Cell Rep
; 33(12): 108542, 2020 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33357423
17.
Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats.
Biopharm Drug Dispos
; 30(9): 532-41, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19862765
18.
Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering.
Drug Metab Pharmacokinet
; 34(1): 25-41, 2019 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-30472066
19.
Effect of streptozotocin-induced diabetes mellitus on the pharmacokinetics of nelfinavir in rats.
Biopharm Drug Dispos
; 29(8): 469-79, 2008 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19009515
20.
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
PLoS One
; 13(12): e0209509, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30592762