Detalhe da pesquisa
1.
Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment.
J Lipid Res
; 64(8): 100408, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37393952
2.
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Bioorg Med Chem Lett
; 27(6): 1364-1370, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28216403
3.
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Bioorg Med Chem Lett
; 25(12): 2488-92, 2015 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25981685
4.
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.
BMC Neurosci
; 14: 90, 2013 Aug 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23981345
5.
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.
J Neurogenet
; 25(1-2): 52-61, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21473737
6.
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat Struct Mol Biol
; 23(4): 293-9, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26950369
7.
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Sci Rep
; 6: 27147, 2016 06 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27256922
8.
2,3-diaminopyridine bradykinin B1 receptor antagonists.
J Med Chem
; 47(26): 6439-42, 2004 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-15588075
9.
Benzodiazepines as potent and selective bradykinin B1 antagonists.
J Med Chem
; 46(10): 1803-6, 2003 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-12723943
10.
Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.
Eur J Pharmacol
; 499(1-2): 77-84, 2004 Sep 19.
Artigo
Inglês
| MEDLINE | ID: mdl-15363953
11.
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Neuropharmacology
; 62(2): 978-87, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22019562
12.
2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 15(9): 2385-8, 2005 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-15837330
13.
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model.
J Pharmacol Exp Ther
; 310(2): 488-97, 2004 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-15051800