Detalhe da pesquisa
1.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
J Am Chem Soc
; 142(28): 12020-12026, 2020 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32579346
2.
A population-based analysis of germline BAP1 mutations in melanoma.
Hum Mol Genet
; 26(4): 717-728, 2017 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28062663
3.
Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".
J Am Chem Soc
; 142(35): 15199, 2020 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32812749
4.
Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe.
RSC Med Chem
; 12(11): 1935-1943, 2021 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34820624
5.
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand.
Nucleic Acids Res
; 36(15): 4975-87, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18658245
6.
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
Mol Cell Biol
; 25(17): 7625-36, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16107709
7.
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.
Nucleic Acids Res
; 34(2): 745-54, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16449207
8.
Deubiquitylating enzymes and drug discovery: emerging opportunities.
Nat Rev Drug Discov
; 17(1): 57-78, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28959952
9.
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
Mech Ageing Dev
; 128(3): 259-66, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17224176
10.
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.
Mol Cell Biol
; 23(23): 8601-13, 2003 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-14612404
11.
Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.
Toxicol In Vitro
; 20(4): 426-38, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16198082
12.
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Nucleic Acids Res
; 32(13): 4003-14, 2004.
Artigo
Inglês
| MEDLINE | ID: mdl-15292449
13.
Werner protein stimulates topoisomerase I DNA relaxation activity.
Cancer Res
; 63(21): 7136-46, 2003 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14612507
14.
Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future.
Methods Mol Biol
; 1449: 395-410, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27613052
15.
Activity Based Profiling of Deubiquitylating Enzymes and Inhibitors in Animal Tissues.
Methods Mol Biol
; 1449: 411-9, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27613053
16.
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.
ACS Chem Biol
; 11(12): 3268-3272, 2016 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-27779380
17.
Pathways and functions of the Werner syndrome protein.
Mech Ageing Dev
; 126(1): 79-86, 2005 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-15610765
18.
Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients.
Mech Ageing Dev
; 125(7): 491-6, 2004 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-15246744
19.
DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene.
Toxicol Sci
; 77(2): 307-14, 2004 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-14691214
20.
Replication stress induces 53BP1-containing OPT domains in G1 cells.
J Cell Biol
; 193(1): 97-108, 2011 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21444690