Detalhe da pesquisa
1.
Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer.
Gastroenterology
; 161(1): 196-210, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33745946
2.
LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice.
J Pharmacol Exp Ther
; 362(1): 85-97, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28442582
3.
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J Med Chem
; 64(20): 15141-15169, 2021 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34643390
4.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34292726
5.
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
Science
; 374(6575): 1632-1640, 2021 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34941392
6.
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
J Med Chem
; 63(17): 9888-9911, 2020 09 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32787110
7.
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.
Cancer Res
; 80(21): 4840-4853, 2020 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32928921
8.
Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.
J Med Chem
; 60(2): 710-721, 2017 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28045524
9.
LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2.
Pharmacol Res Perspect
; 3(2): e00129, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26038705